메뉴 건너뛰기




Volumn 26, Issue 1, 2009, Pages 23-36

Black cohosh for the management of menopausal symptoms: A systematic review of clinical trials

Author keywords

Cimicifuga, therapeutic use; Climacteric, treatment; Herbal medicines, therapeutic use; Menopause, treatment

Indexed keywords

20ALPHA DIHYDROPROGESTERONE; CIMICIFUGA RACEMOSA EXTRACT; CONJUGATED ESTROGEN; DIAZEPAM; ESTRADIOL; ESTRIOL; ESTROGEN; FLUOXETINE; GYNO PLUS; HYPERICIN; HYPERICUM PERFORATUM EXTRACT; TIBOLONE; UNCLASSIFIED DRUG;

EID: 58149109020     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/0002512-200926010-00002     Document Type: Review
Times cited : (36)

References (35)
  • 1
    • 58149105111 scopus 로고    scopus 로고
    • International Menopause Society, online, Available from URL:, Accessed 2008 Oct 21
    • International Menopause Society. Menopause terminology [online]. Available from URL: http://www.imsociety.org/menopause_terminology.html [Accessed 2008 Oct 21]
    • Menopause terminology
  • 2
    • 33645458030 scopus 로고    scopus 로고
    • Black cohosh and St. John's wort for climacteric complaints: A randomized trial
    • Feb;
    • Uebelhack R, Blohmer JU, Graubaum HJ, et al. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol 2006 Feb; 107 (2 Pt 1): 247-55
    • (2006) Obstet Gynecol , vol.107 , Issue.2 PART 1 , pp. 247-255
    • Uebelhack, R.1    Blohmer, J.U.2    Graubaum, H.J.3
  • 3
    • 84856253470 scopus 로고    scopus 로고
    • The menopause transition and postmenopausal hormone therapy
    • Fauci AS, Braunwald E, Kasper DL, et al, eds, 17th ed. New York: The McGraw-Hill Companies, Inc;
    • Manson JE, Bassuk SS. The menopause transition and postmenopausal hormone therapy. In: Fauci AS, Braunwald E, Kasper DL, et al., eds. Harrison's principles of internal medicine. 17th ed. New York: The McGraw-Hill Companies, Inc; 2008: 2334-9
    • (2008) Harrison's principles of internal medicine , pp. 2334-2339
    • Manson, J.E.1    Bassuk, S.S.2
  • 4
    • 33846928992 scopus 로고    scopus 로고
    • Vasomotor symptoms in menopause: Physiologic condition and central nervous system approaches to treatment
    • Feb;
    • Rapkin AJ. Vasomotor symptoms in menopause: physiologic condition and central nervous system approaches to treatment. Am J Obstet Gynecol 2007 Feb; 196 (2): 97-106
    • (2007) Am J Obstet Gynecol , vol.196 , Issue.2 , pp. 97-106
    • Rapkin, A.J.1
  • 5
    • 33947604311 scopus 로고    scopus 로고
    • Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: Randomized, controlled, double-blind pilot study
    • Feb;
    • Rotem C, Kaplan B. Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study. Gynecol Endocrinol 2007 Feb; 23 (2): 117-22
    • (2007) Gynecol Endocrinol , vol.23 , Issue.2 , pp. 117-122
    • Rotem, C.1    Kaplan, B.2
  • 6
    • 39049187163 scopus 로고    scopus 로고
    • Newton KM, Reed SD, LaCroix AZ, et al. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Intern Med 2006 Dec 19; 145 (12): 869-79
    • Newton KM, Reed SD, LaCroix AZ, et al. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Intern Med 2006 Dec 19; 145 (12): 869-79
  • 7
    • 4644238003 scopus 로고    scopus 로고
    • Estrogen plus progestin and risk of venous thrombosis
    • for the Women's Health Initiative Investigators
    • Cushman M, Kuller LH, Prentice R, et al., for the Women's Health Initiative Investigators. Estrogen plus progestin and risk of venous thrombosis. JAMA 2004; 293: 1573-80.
    • (2004) JAMA , vol.293 , pp. 1573-1580
    • Cushman, M.1    Kuller, L.H.2    Prentice, R.3
  • 8
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative Randomized Controlled Trial
    • Writing Group for the Women's Health Initiative Investigators
    • Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative Randomized Controlled Trial. JAMA 2002; 288 (3): 321-7
    • (2002) JAMA , vol.288 , Issue.3 , pp. 321-327
  • 9
    • 0642275971 scopus 로고    scopus 로고
    • A systematic review of herbal medicinal products for the treatment of menopausal symptoms
    • Sep-Oct;
    • Huntley AL, Ernst E. A systematic review of herbal medicinal products for the treatment of menopausal symptoms. Menopause 2003 Sep-Oct; 10 (5): 465-76
    • (2003) Menopause , vol.10 , Issue.5 , pp. 465-476
    • Huntley, A.L.1    Ernst, E.2
  • 10
    • 15944403978 scopus 로고    scopus 로고
    • Efficacy of Cimicifuga racemosa on climacteric complaints: A randomized study versus low-dose transdermal estradiol
    • Jan;
    • Nappi RE, Malavasi B, Brundu B, et al. Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol. Gynecol Endocrinol 2005 Jan; 20 (1): 30-5
    • (2005) Gynecol Endocrinol , vol.20 , Issue.1 , pp. 30-35
    • Nappi, R.E.1    Malavasi, B.2    Brundu, B.3
  • 11
    • 34248191240 scopus 로고    scopus 로고
    • Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms
    • Apr 30
    • Chung DJ, Kim HY, Park KH, et al. Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms. Yonsei Med J Apr 30 2007; 48 (2): 289-94
    • (2007) Yonsei Med J , vol.48 , Issue.2 , pp. 289-294
    • Chung, D.J.1    Kim, H.Y.2    Park, K.H.3
  • 12
    • 33845506470 scopus 로고    scopus 로고
    • Short-term effects of a combination of isoflavones, lignans and Cimicifuga racemosa on climacteric-related symptoms in postmenopausal women: A double-blind, randomized, placebo-controlled trial
    • Nov;
    • Sammartino A, Tommaselli GA, Gargano V, et al. Short-term effects of a combination of isoflavones, lignans and Cimicifuga racemosa on climacteric-related symptoms in postmenopausal women: a double-blind, randomized, placebo-controlled trial. Gynecol Endocrinol 2006 Nov; 22 (11): 646-50
    • (2006) Gynecol Endocrinol , vol.22 , Issue.11 , pp. 646-650
    • Sammartino, A.1    Tommaselli, G.A.2    Gargano, V.3
  • 13
    • 0036372056 scopus 로고    scopus 로고
    • Herbs, menopause, and dialysis
    • Jan-Feb;
    • Roemheld-Hamm B, Dahl NV. Herbs, menopause, and dialysis. Semin Dial 2002 Jan-Feb; 15 (1): 53-9
    • (2002) Semin Dial , vol.15 , Issue.1 , pp. 53-59
    • Roemheld-Hamm, B.1    Dahl, N.V.2
  • 14
    • 6344278735 scopus 로고    scopus 로고
    • The role of complementary and alternative medicine in management of menopausal symptoms
    • Dec;
    • Kessel B, Kronenberg F. The role of complementary and alternative medicine in management of menopausal symptoms. Endocrinol Metab Clin North Am 2004 Dec; 33 (4): 717-39
    • (2004) Endocrinol Metab Clin North Am , vol.33 , Issue.4 , pp. 717-739
    • Kessel, B.1    Kronenberg, F.2
  • 15
    • 33646755892 scopus 로고    scopus 로고
    • Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: A double-blind, placebo-controlled, and conjugated estrogens-controlled study
    • Mar-Apr;
    • Wuttke W, Gorkow C, Seidlova-Wuttke D. Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study. Menopause 2006 Mar-Apr; 13 (2): 185-96
    • (2006) Menopause , vol.13 , Issue.2 , pp. 185-196
    • Wuttke, W.1    Gorkow, C.2    Seidlova-Wuttke, D.3
  • 16
    • 0037436823 scopus 로고    scopus 로고
    • The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: Effects on menopause symptoms and bone markers
    • Mar 14;
    • Wuttke W, Seidlova-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas 2003 Mar 14; 44 Suppl. 1: S67-77
    • (2003) Maturitas , vol.44 , Issue.SUPPL. 1
    • Wuttke, W.1    Seidlova-Wuttke, D.2    Gorkow, C.3
  • 17
    • 38049012384 scopus 로고    scopus 로고
    • Vaginal, endometrial, and reproductive hormone findings: Randomized, placebo-controlled trial of black cohosh, multibotanical herbs, and dietary soy for vasomotor symptoms: the Herbal Alternatives for Menopause (HALT) Study
    • Jan-Feb;
    • Reed SD, Newton KM, LaCroix AZ, et al. Vaginal, endometrial, and reproductive hormone findings: randomized, placebo-controlled trial of black cohosh, multibotanical herbs, and dietary soy for vasomotor symptoms: the Herbal Alternatives for Menopause (HALT) Study. Menopause 2008 Jan-Feb; 15 (1): 51-8
    • (2008) Menopause , vol.15 , Issue.1 , pp. 51-58
    • Reed, S.D.1    Newton, K.M.2    LaCroix, A.Z.3
  • 18
    • 34250868925 scopus 로고    scopus 로고
    • Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: A prospective, randomized trial
    • Mar-Apr;
    • Oktem M, Eroglu D, Karahan HB, et al. Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial. Adv Ther 2007 Mar-Apr; 24 (2): 448-61
    • (2007) Adv Ther , vol.24 , Issue.2 , pp. 448-461
    • Oktem, M.1    Eroglu, D.2    Karahan, H.B.3
  • 19
    • 36849044215 scopus 로고    scopus 로고
    • Black cohosh does not exert an estrogenic effect on the breast
    • Ruhlen RL, Haubner J, Tracy JK, et al. Black cohosh does not exert an estrogenic effect on the breast. Nutr Cancer 2007; 59 (2): 269-77
    • (2007) Nutr Cancer , vol.59 , Issue.2 , pp. 269-277
    • Ruhlen, R.L.1    Haubner, J.2    Tracy, J.K.3
  • 20
    • 0035873937 scopus 로고    scopus 로고
    • Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer
    • May 15;
    • Jacobson JS, Troxel AB, Evans J, et al. Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. J Clin Oncol 2001 May 15; 19 (10): 2739-45
    • (2001) J Clin Oncol , vol.19 , Issue.10 , pp. 2739-2745
    • Jacobson, J.S.1    Troxel, A.B.2    Evans, J.3
  • 21
    • 0037137171 scopus 로고    scopus 로고
    • Complementary and alternative medicine for menopausal symptoms: A review of randomized, controlled trials
    • Nov 19;
    • Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 2002 Nov 19; 137 (10): 805-13
    • (2002) Ann Intern Med , vol.137 , Issue.10 , pp. 805-813
    • Kronenberg, F.1    Fugh-Berman, A.2
  • 22
    • 22544487185 scopus 로고    scopus 로고
    • Cimicifuga racemosa dried ethanolic extract in menopausal disorders: A double-blind placebo-controlled clinical trial
    • Aug 16;
    • Frei-Kleiner S, Schaffner W, Rahlfs VW, et al. Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial. Maturitas 2005 Aug 16; 51 (4): 397-404
    • (2005) Maturitas , vol.51 , Issue.4 , pp. 397-404
    • Frei-Kleiner, S.1    Schaffner, W.2    Rahlfs, V.W.3
  • 23
    • 17644387207 scopus 로고    scopus 로고
    • Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms
    • May;
    • Osmers R, Friede M, Liske E, et al. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol 2005 May; 105 (5 Pt 1): 1074-83
    • (2005) Obstet Gynecol , vol.105 , Issue.5 PART 1 , pp. 1074-1083
    • Osmers, R.1    Friede, M.2    Liske, E.3
  • 24
    • 33745569000 scopus 로고    scopus 로고
    • Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1
    • Jun 20;
    • Pockaj BA, Gallagher JG, Loprinzi CL, et al. Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1. J Clin Oncol 2006 Jun 20; 24 (18): 2836-41
    • (2006) J Clin Oncol , vol.24 , Issue.18 , pp. 2836-2841
    • Pockaj, B.A.1    Gallagher, J.G.2    Loprinzi, C.L.3
  • 25
    • 34547952205 scopus 로고    scopus 로고
    • Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: A randomized, double blind, parallel-controlled study versus tibolone
    • Sep 20;
    • Bai W, Henneicke-von Zepelin HH, Wang S, et al. Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone. Maturitas 2007 Sep 20; 58 (1): 31-41
    • (2007) Maturitas , vol.58 , Issue.1 , pp. 31-41
    • Bai, W.1    Henneicke-von Zepelin, H.H.2    Wang, S.3
  • 26
    • 0032086903 scopus 로고    scopus 로고
    • A review of the effectiveness of Cimicifuga racemosa (black cohosh) for the symptoms of menopause
    • Jun;
    • Lieberman S. A review of the effectiveness of Cimicifuga racemosa (black cohosh) for the symptoms of menopause. J Womens Health 1998 Jun; 7 (5): 525-9
    • (1998) J Womens Health , vol.7 , Issue.5 , pp. 525-529
    • Lieberman, S.1
  • 27
    • 0023925558 scopus 로고
    • Clinical and endocrinologic studies of the treatment of ovarian insufficiency manifestrolled tations following hysterectomy with intact adnexa
    • Lehmann-Willenbrock E, Riedel HH. Clinical and endocrinologic studies of the treatment of ovarian insufficiency manifestrolled tations following hysterectomy with intact adnexa. Zentralbl Gynakol 1988; 110 (10): 611-8
    • (1988) Zentralbl Gynakol , vol.110 , Issue.10 , pp. 611-618
    • Lehmann-Willenbrock, E.1    Riedel, H.H.2
  • 28
    • 0001885694 scopus 로고
    • Phytotherapy influences atrophic vaginal epithelium: Double-blind study of Cimicifuga vs. estrogenic substances
    • in German
    • Stoll W. Phytotherapy influences atrophic vaginal epithelium: double-blind study of Cimicifuga vs. estrogenic substances [in German]. Therapeutikon 1987; 1: 23-31
    • (1987) Therapeutikon , vol.1 , pp. 23-31
    • Stoll, W.1
  • 29
    • 0000757130 scopus 로고
    • Using phyto-treatment to influence menopause symptoms
    • Warnecke G. Using phyto-treatment to influence menopause symptoms. Med Welt 1985; 36: 871-4
    • (1985) Med Welt , vol.36 , pp. 871-874
    • Warnecke, G.1
  • 30
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
    • Feb;
    • Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996 Feb; 17 (1): 1-12
    • (1996) Control Clin Trials , vol.17 , Issue.1 , pp. 1-12
    • Jadad, A.R.1    Moore, R.A.2    Carroll, D.3
  • 31
    • 34047273025 scopus 로고    scopus 로고
    • Cutaneous vasculitis in two patients taking an herbal supplement containing black cohosh
    • May;
    • Ingraffea A, Donohue K, Wilkel C, et al. Cutaneous vasculitis in two patients taking an herbal supplement containing black cohosh. J Am Acad Dermatol 2007 May; 56 (5 Suppl.): S124-6
    • (2007) J Am Acad Dermatol , vol.56 , Issue.5 SUPPL.
    • Ingraffea, A.1    Donohue, K.2    Wilkel, C.3
  • 32
    • 23044490534 scopus 로고    scopus 로고
    • Black cohosh (Actaea/Cimicifuga racemosa): Review of the clinical data for safety and efficacy in menopausal symptoms
    • Mahady GB. Black cohosh (Actaea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms. Treat Endocrinol 2005; 4 (3): 177-84
    • (2005) Treat Endocrinol , vol.4 , Issue.3 , pp. 177-184
    • Mahady, G.B.1
  • 33
    • 33745500247 scopus 로고    scopus 로고
    • Fulminant hepatic failure associated with the use of black cohosh: A case report
    • Jun;
    • Lynch CR, Folkers ME, Hutson WR. Fulminant hepatic failure associated with the use of black cohosh: a case report. Liver Transpl 2006 Jun; 12 (6): 989-92
    • (2006) Liver Transpl , vol.12 , Issue.6 , pp. 989-992
    • Lynch, C.R.1    Folkers, M.E.2    Hutson, W.R.3
  • 34
    • 14944361241 scopus 로고    scopus 로고
    • Autoimmune hepatitis associated with the use of black cohosh: A case study
    • Sep-Oct;
    • Cohen SM, O'Connor AM, Hart J, et al. Autoimmune hepatitis associated with the use of black cohosh: a case study. Menopause 2004 Sep-Oct; 11 (5): 575-7
    • (2004) Menopause , vol.11 , Issue.5 , pp. 575-577
    • Cohen, S.M.1    O'Connor, A.M.2    Hart, J.3
  • 35
    • 29144529204 scopus 로고    scopus 로고
    • Muscle damage induced by black cohosh (Cimicifuga racemosa)
    • Jan;
    • Minciullo PL, Saija A, Patafi M, et al. Muscle damage induced by black cohosh (Cimicifuga racemosa). Phytomedicine 2006 Jan; 13 (1-2): 115-8
    • (2006) Phytomedicine , vol.13 , Issue.1-2 , pp. 115-118
    • Minciullo, P.L.1    Saija, A.2    Patafi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.