Antitumor effect of saffron (Crocus sativus L.): Overview and perspectives

Acta Horticulturae

Volumn 650, Issue , 2004, Pages 491-499

  Abdullaev, Fikrat I ^a  

^a INSTITUTO NACIONAL DE PEDIATRÍA   (Mexico)

Author keywords

Cancer; Chemoprevention; Cytotoxicity; Genotoxicity; Human normal and malignant cells; Saffron

Indexed keywords

EID: 58149106015     PISSN: 05677572     EISSN: None     Source Type: Book Series    
DOI: 10.17660/ActaHortic.2004.650.60     Document Type: Conference Paper

References (40)

1. Abdullaev, F. I. and Frenkel, G. D. 1992a. Effect of saffron on cell colony formation and cellular nucleic acid and protein synthesis. BioFactors 3:201-205.
2. Abdullaev, F. I. and Frenkel, G. D. 1992b. The effect of saffron on intracellular DNA, RNA and protein synthesis in malignant and non-malignant human cells colony. BioFactors 4:43-45.
3. Abdullaev, F. I. 1993. Biological effects of saffron. BioFactors 4:83-86.
4. Abdullaev, F. I. 1994. Inhibitory effect of crocetin on intracellular nucleic acid and protein synthesis in malignant cells. Toxicology Lett. 40:243-251.
5. Abdullaev, F. I. 2001. Plant-derived agents against cancer. In: Gupta, S. K. (ed.) Pharmacology and Therapeutics in the New Millennium. Narosa Pub. House, New Delhi, India. Pp. 345-354.
6. Abdullaev, F. I. 2002. Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.). Exp. Biol. Med. 247:20-25.
7. Abdullaev, F. 2003a. Crocus sativus against cancer. Arch. Med. Res. 34:354.
8. Abdullaev, F. 2003b. Saffron (Crocus sativus L.) and its possible role in the prevention of cancer. Recent Prog. Med. Plants 8:69-82.
9. Abdullaev, F. I. and González De Mejía, E. 1995. Inhibition of colony formation of HeLa cells by naturally occurring and synthetic agents. BioFactors 5:133-138.
10. Abdullaev Jafarova, F., Caballero-Ortega, H., Riverón-Negrete, L., Pereda-Miranda, R., Hernández, J-M-, Pérez-López, I. and Espinosa-Aguirre, J. J. 2002. Evaluación in vitro del potencial quimiopreventivo del azafrán. Rev. Inv. Clin. 54:430-436.
11. Abdullaev, F., Riverón-Negrete, L., Caballero-Ortega, H., Pereda-Miranda, R., Rivera-Luna, R., Hernández, J-M-, Pérez-López, I, and Espinosa-Aguirre, J. J. 2003. Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L.). Toxicol. In Vitro 17:751.
12. Deng, Y., Guo, Z. G., Zeng, Z. L. and Wang Z. 2002. Studies on the pharmacological effects of saffron (Crocus sativus L.): a review. Zhongguo Zhong Yao Za Zhi 27:565-568.
13. El Daly, E. S. 1998. Protective effect of cysteine and vitamine E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats. J. Pharm. Belg. 53:87-93.
14. Escribano, J., Alonso, G. L., Coca-Prados M. and Fernández, J. A. 1996. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett. 100:23-30.
15. Escribano, J., Piqueras, A., Medina, J., Ríos, J. and Fernández, J. A. 1999a. Isolation and cytotoxic properties of novel gly coconjugate from corms of saffron plant (Crocus sativus L.). Biochem. Biophys. Acta 1426:217-222.
16. Escribano, J., Piqueras, A., Medina, J., Rubio, A., Álvarez- Ortí, M. and Fernández, J. A. 1999b. Production of a cytotoxic proteoglycan using callus culture of saffron corms (Crocus sativus L.). J. Biotechnol. 73:53-59.
17. Escribano, J., Díaz-Guerra, M. J. M., Riese, H. H., Ontañón, J., García-Olmo, D., García-Olmo, D. C., Rubio, A. and Fernández, J. A. 1999c. In vitro activation of macrophages from corm of Crocus sativus L. Cancer Lett. 144:107-114.
18. Escribano, J., Díaz-Guerra, M. J. M., Riese, H. H., Álvarez, A., Proenza, R. and Fernández, J. A. 2000. The cytotoxic effect of glucoconjugate extracted from corms of saffron plant (Crocus sativus L.) on human cell lines in culture. Planta Med. 66:157-162.
19. Fernández, J. A., Escribano, J., Piqueras, A. and Medina, J. 2000. A glucoconjugate from corms of saffron plant (Crocus sativus L.) inhibits root growth and effects in vitro cell viability. J. Exp. Bot. 51:731-737.
20. García-Olmo, D. C., Riese, H. H., Escribano, J., Ontañón, J., Fernández J. A., Atiénzar, M. and García-Olmo, D. 1999. Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): an experimental study in the rats. Nutr. Cancer 35:120-126.
21. Kasumov, F. J., Abdullaev, F. I. and Frenkel, G. D. 1998. Inhibitory effect of safranal on the growth of HeLa tumor cells. Dokl. Acad. Nauk. Azerb. LIV: 70-73.
22. Kubo, I. and Kinst-Hori, I. 1999. Flavonols from saffron flower: tyrosine inhibitory activity and inhibition mechanism. J. Agric. Food Chem. 47:4121-4125.
23. Martin, G., Goh, E. and Neff, A. W. 2002. Evaluation of the developmental toxicity of crocetin on Xenopus. Food Chem. Toxicol. 40:959-964.
24. Morjani, H., Tarantilis, P., Polissiou, M. and Manfait, M. 1990. Growth inhibition and induction of crythroid differentiation activity by crocin, dimethylcrocetine and β-carotene on K562 tumour cells. Anticancer Res. 10:1398-1406.
25. Molnar, J., Szabo, D., Pusztai, R., Mucsi, I., Berek, L., Ocsovszki, I., Kawata, E. and Shoyama, Y. 2000. Membrane associated antitumour effects of crocin-, ginsenoidand cannabinoid derivatives. Anticancer Res. 20:861-867.
26. Nair, S. C., Pannikar, B. and Pannikar, K. R. 1991a. Antitumor activity of saffron (Crocus sativus). Cancer Lett. 57:109-114.
27. Nair, S. C., Salomi, M. J., Pannikar, B. and Pannikar, K. R. 1991b. Modulatory effects of the extracts of saffron and Nigela sativus against cisplatinum induced toxicity in mice. J. Ethnopharmacol. 31:75-83.
28. Nair, S. C., Salomi, M. J., Varghese, C. D., Pannikar, B. and Pannikar, K. R. 1992. Effect of saffron on thymocyte proliferation, intracellular gluthation levels, and its antitumor activity. BioFactors 4:51-54.
29. Nair, S. C., Varghese, C. D., Pannikar, K. R., Kurumboor, S. K. and Parathod, R. K. 1994. Effects of saffron on vitamin A levels and its antitumor activity on the growth of solid tumors in mice. Int. J. Pharmacg. 32:105-114.
30. Nair, S. C., Kurumboor, S. K. and Hasegawa, J. H. 1995. Saffron chemoprevention in biology and medicine: a review. Cancer Biother. 10:257-264.
31. Premkumar, K., Abraham, S. K., Santhiya, S. T., Gopinath, P. M. and Ramesh, A. 2001. Inhibition of genotoxicity by saffron (Crocus sativus L.) in mice. Drug Chem. Toxicol. 24:421-428.
32. Premkumar, K., Abraham, S. K., Santhiya, S. T. and Ramesh, A. 2003. Protective effects of saffron (Crocus sativus L.) on genotoxin-induced oxidative stress in Swiss albino mice. Phytother. Res. 17:614-617.
33. Ríos, J. L., Recio, M. C., Giner, R. M. and Máñez S. 1996. An update review of saffron and its active constituents. Phytother. Res. 110:189-193.
34. Riverón-Negrete, L., Camacho-Carranza, R., Caballero-Ortega, H., Hernández, J. M., Medécigo-Ríos, M., Castillo-Villanueva, A., Pérez-López, I., Espinosa-Aguirre, J. J. and Abdullaev, F. I. 2004. Additive inhibitory effect of saffron in combination with sodium selenite on tumor cells. Acta Hort. (in press).
35. Salomi, M. J., Nair, S. C. and Pannikar, K. R. 1991. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutr. Cancer 16:67-72.
36. Soeda, S., Ochiai, T., Paopong, L., Tanaka, H., Shoyama, Y. and Shimeno H. 2001. Crocin suppresses tumor necrosis factor-alpha-induced cell death of neuronally differentiated PC-12 cells. Life Sci. 69:2887-2898.
37. Tarantilis, P. A., Morjani, H., Polissiou, M. and Manfait, M. 1994. Inhibition of growth and induction of differentiation promyelocytic leukemia (HL-60) by carotenoids from Crocus sativus L. Anticancer Res. 14:1913-1918.
38. Verma, S. K. and Bordia, A. 1998. Antioxidant property of saffron in man. Indian J. Med. Sci. 52:205-207.
39. Winterhalter, P. and Straubinger, M. 2000. Saffron-renewed interest in an ancient spice. Food Rev. Int. 16:39-59.
40. Zareena, A. V., Variar, P. S., Cholar, A. S. and Bongirwar, D. F. 2001. Chemical investigation of y-irradiated saffron (Crocus sativus L.). J. Agric. Food Chem. 49:687-691.