A study on improvement of solubility of rofecoxib and its effect on permeation of drug from topical formulations

Indian Journal of Pharmaceutical Sciences

Volumn 70, Issue 4, 2008, Pages 466-471

  Kulkarni, Madhur ^a   Nagarsenkar, Mangal ^a  

^a BOMBAY COLLEGE OF PHARMACY   (India)

Author keywords

cyclodextrin; Binary mixture; In vitro skin permeation; Rofecoxib

Indexed keywords

BETA CYCLODEXTRIN; METHANOL; ROFECOXIB; WATER;

ARTICLE; DRUG FORMULATION; DRUG MIXTURE; DRUG SOLUBILITY; EVAPORATION; GEL; SKIN PERMEABILITY;

EID: 58149087456     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: 10.4103/0250-474X.44595     Document Type: Article

References (13)

1. Connors EP, editor. Physicians' Desk Reference. 55th ed. New Jersy, USA: Medical Economoics Company Inc; 2001. p. 2049-50.
2. Singh A, Singh B, Ahuja N. RXB: An update on physicochemical, pharmaceutical, pharmacodynamic and pharmacokinetic aspects. J Pharm Pharmacol 2004;55:859-94.
3. Yener G, Gonullu U, Uner M , Degim T, Araman A. Effect of vehicles and penetration enhancers on the in vitro percutaneous absorption of Celcecoxib through human skin. Pharmazie 2003;58:330-3.
4. Barry BW. Dermatological Formulations- Percutaneous Absorption. New York: Marcel Dekker Inc.; 1983. p. 167-8.
5. Bekerso J, Ujtendaal EV, Beijnen J, Bult A. Cyclodextrins in pharmaceutical field. Drug Develop Ind Pharm 1991;17:1503-49.
6. Udupa N, Narsimha Reddy D. Formulation and evaluation of oral and transdermal preparations of flurbiprofen and piroxicam incorporated with different carriers. Drug Develop Ind Pharm 1993;19:834-52.
7. Udupa N, Singh UV, Pandey S. Drug carriers for transdermal preparations of flurbiprofen. Drug Develop Ind Pharm 1994;20:1811-20.
8. Loftson T, Frioriksdottir G, Jonsdottir B. The influence of 2-hydroxypropyl β cyclodextrin on diffusion rates and transdermal delivery of hydrocortisone. Drug Develop Ind Pharm 1994;20:1699-708.
9. Tenjarla SN, Puranjoti P, Kasina R, Mandal T. Preparation, characterization and evaluation of miconazole-cyclodextrin complexes for improved oral and topical delivery. J Pharm Sci 1998;87:425-9.
10. Matsuda H, Arima H. Cyclodextrins in transdermal delivery. Adv Drug Del Rev 1999;36:81-99.
11. Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem Instr 1965;4:117-212.
12. Kitagawa S, Ikarashi A. Enhanced skin permeation of cationic drug ketotifen, through excised guinea pig dorsal skin, by surfactants with different charge. Chem Pharm Bull 2003;51:1183-5.
13. Shim J, Seok KH, Park WS, Han SH, Kim J, Chang IS. Transdermal delivery of minoxodil with block copolymer nanoparticles. J Control Release 2004;97:477-84.