Renal transplantation with early steroid withdrawal

Pediatric Nephrology

Volumn 24, Issue 2, 2009, Pages 243-251

  Schiff, Jeffrey ^a   Cole, Edward H ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Acute rejection; Corticosteroids; Graft survival; Immunosuppression; Renal transplantation

Indexed keywords

ALEMTUZUMAB; ANTIDIABETIC AGENT; AZATHIOPRINE; BASILIXIMAB; CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOSPORIN; CYCLOSPORIN A; DACLIZUMAB; INTERLEUKIN 2 RECEPTOR ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE GRAFT REJECTION; ADJUVANT THERAPY; AVASCULAR NECROSIS; CARDIOVASCULAR DISEASE; CATARACT; CHRONIC ALLOGRAFT NEPHROPATHY; CLINICAL TRIAL; CORTICOSTEROID INDUCED OSTEOPOROSIS; CREATININE CLEARANCE; DELAYED GRAFT FUNCTION; DRUG DOSE REDUCTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EDEMA; GLUCOSE INTOLERANCE; GRAFT FAILURE; GRAFT SURVIVAL; GROWTH DISORDER; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LEUKOPENIA; LOW DRUG DOSE; LYMPHOPROLIFERATIVE DISEASE; MONOTHERAPY; MOON FACE; NEPHROTOXICITY; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; SKIN DISEASE; SURVIVAL RATE; WEIGHT GAIN;

ACUTE DISEASE; ADRENAL CORTEX HORMONES; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; KIDNEY TRANSPLANTATION; RISK FACTORS;

EID: 58149085293     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-008-0876-0     Document Type: Review

References (46)

1. Prasad GV, Nash MM, McFarlane PA, Zaltzman JS (2003) Renal transplant recipient attitudes toward steroid use and steroid withdrawal. Clin Transplant 17:135-139
2. Hricik DE, O'Toole MA, Schulak JA, Herson J (1993) Steroid-free immunosuppression in cyclosporine-treated renal transplant recipients: A meta-analysis. J Am Soc Nephrol 4:1300-1305
3. Sinclair NR (1992) Low-dose steroid therapy in cyclosporine-treated renal transplant recipients with well-functioning grafts. The Canadian Multicentre Transplant Study Group. CMAJ 147:645-657
4. Ahsan N, Hricik D, Matas A, Rose S, Tomlanovich S, Wilkinson A, Ewell M, McIntosh M, Stablein D, Hodge E (1999) Prednisone withdrawal in kidney transplant recipients on cyclosporine and mycophenolate mofetil - a prospective randomized study. Steroid Withdrawal Study Group. Transplantation 68:1865-1874
5. Vanrenterghem Y, Lebranchu Y, Hene R, Oppenheimer F, Ekberg H (2000) Double-blind comparison of two corticosteroid regimens plus mycophenolate mofetil and cyclosporine for prevention of acute renal allograft rejection. Transplantation 70:1352-1359
6. Kasiske BL, Chakkera HA, Louis TA, Ma JZ (2000) A meta-analysis of immunosuppression withdrawal trials in renal transplantation. J Am Soc Nephrol 11:1910-1917
7. Pascual J, Quereda C, Zamora J, Hernandez D (2004) Steroid withdrawal in renal transplant patients on triple therapy with a calcineurin inhibitor and mycophenolate mofetil: A meta-analysis of randomized, controlled trials. Transplantation 78:1548-1556
8. Andreoni KA, Brayman KL, Guidinger MK, Sommers CM, Sung RS (2007) Kidney and pancreas transplantation in the United States, 1996-2005. Am J Transplant 7:1359-1375
9. Matas AJ, Ramcharan T, Paraskevas S, Gillingham KJ, Dunn DL, Gruessner RW, Humar A, Kandaswamy R, Najarian JS, Payne WD, Sutherland DE (2001) Rapid discontinuation of steroids in living donor kidney transplantation: A pilot study. Am J Transplant 1:278-283
10. Khwaja K, Asolati M, Harmon JV, Melancon JK, Dunn TB, Gillingham KJ, Kandaswamy R, Humar A, Gruessner RW, Payne WD, Najarian JS, Dunn DL, Sutherland DE, Matas AJ (2004) Rapid discontinuation of prednisone in higher-risk kidney transplant recipients. Transplantation 78:1397-1399
11. Kumar MS, Heifets M, Moritz MJ, Saeed MI, Khan SM, Fyfe B, Sustento-Riodeca N, Daniel JN, Kumar A (2006) Safety and efficacy of steroid withdrawal two days after kidney transplantation: Analysis of results at three years. Transplantation 81:832-839
12. Haririan A, Sillix DH, Morawski K, El-Amm JM, Garnick J, Doshi MD, West MS, Gruber SA (2006) Short-term experience with early steroid withdrawal in African-American renal transplant recipients. Am J Transplant 6:2396-2402
13. Kato Y, Tojimbara T, Iwadoh K, Koyama I, Nanmoku K, Kai K, Sannomiya A, Nakajima I, Fuchinoue S, Teraoka S (2006) Early steroid withdrawal protocol with basiliximab, cyclosporine and mycophenolate mofetil in renal-transplant recipients. Int Immunopharmacol 6:1984-1992
14. Reisman L, Lieberman KV, Burrows L, Schanzer H (1990) Follow-up of cyclosporine-treated pediatric renal allograft recipients after cessation of prednisone. Transplantation 49:76-80
15. Ingulli E, Tejani A, Markell M (1993) The beneficial effects of steroid withdrawal on blood pressure and lipid profile in children posttransplantation in the cyclosporine era. Transplantation 55:1029-1033
16. Chao SM, Jones CL, Powell HR, Johnstone L, Francis DM, Becker GJ, Walker RG (1994) Triple immunosuppression with subsequent prednisolone withdrawal: 6 years' experience in paediatric renal allograft recipients. Pediatr Nephrol 8:62-69
17. Roberti I, Reisman L, Lieberman KV, Burrows L (1994) Risk of steroid withdrawal in pediatric renal allograft recipients (a 5-year follow-up). Clin Transplant 8:405-408
18. Klaus G, Jeck N, Konrad M, Forster B, Soergel M (2001) Risk of steroid withdrawal in pediatric renal transplant patients with suspected steroid toxicity. Clin Nephrol 56:S37-S42
19. Ellis D (2000) Growth and renal function after steroid-free tacrolimus-based immunosuppression in children with renal transplants. Pediatr Nephrol 14:689-694
20. Benfield MR, Munoz R, Warshaw BL, Bartosh SM, Stablein DM, McIntosh MJ, Bridges ND, Harmon WE (2005) A randomized controlled double-blind trial of steroid withdrawal in pediatric renal transplantation: A study of the cooperative clinical trials in pediatric transplantation. American Transplant Congress, Seattle, USA
21. Oberholzer J, John E, Lumpaopong A, Testa G, Sankary HN, Briars L, Kraft KA, Knight PS, Verghese P, Benedetti E (2005) Early discontinuation of steroids is safe and effective in pediatric kidney transplant recipients. Pediatr Transplant 9:456-463
22. Bhakta N, Rianthavorn P, Marik J, Gjertson D, Gritsch HA, Malekzadeh M, Ettenger R (2006) Can pediatric steroid free transplantation improve growth and metabolic complications? A retrospective case control trial with contemporaneous controls. American Transplant Congress, Boston, USA
23. Lau KK, Haddad MN, Berg GM, Perez RV, Butani L (2007) Rapid steroid discontinuation for pediatric renal transplantation: A single center experience. Pediatr Transplant 11:504-510
24. Bartosh SM, Sanchez CP, Leverson G, Sollinger HW, Knechtle SJ (2006) Pilot trial of steroid free immunosuppression following campath-1h induction in pediatric renal transplants. American Transplant Congress, Boston, USA
25. Shapiro R, Ellis D, Tan HP, Moritz ML, Basu A, Vats AN, Kayler LK, Erkan E, McFeaters CG, James G, Grosso MJ, Zeevi A, Gray EA, Marcos A, Starzl TE (2006) Alemtuzumab preconditioning and tacrolimus monotherapy in pediatric kidney transplant recipients. American Transplant Congress, Boston, USA
26. Sarwal MM, Yorgin PD, Alexander S, Millan MT, Belson A, Belanger N, Granucci L, Major C, Costaglio C, Sanchez J, Orlandi P, Salvatierra O Jr (2001) Promising early outcomes with a novel, complete steroid avoidance immunosuppression protocol in pediatric renal transplantation. Transplantation 72:13-21
27. Sarwal MM, Vidhun JR, Alexander SR, Satterwhite T, Millan M, Salvatierra O Jr (2003) Continued superior outcomes with modification and lengthened follow-up of a steroid-avoidance pilot with extended daclizumab induction in pediatric renal transplantation. Transplantation 76:1331-1339
28. Silverstein DM, Aviles DH, LeBlanc PM, Jung FF, Vehaskari VM (2005) Results of one-year follow-up of steroid-free immunosuppression in pediatric renal transplant patients. Pediatr Transplant 9:589-597
29. Woodle ES; the Astellas Steroid Withdrawal Group (2007) A randomized double blind, placebo-controlled trial of early corticosteroid cessation versus chronic corticosteroids: Four year results. American Transplant Congress, San Francisco, USA
30. Vincenti F, Monaco A, Grinyo J, Kinkhabwala M, Roza A (2003) Multicenter randomized prospective trial of steroid withdrawal in renal transplant recipients receiving basiliximab, cyclosporine microemulsion and mycophenolate mofetil. Am J Transplant 3:306-311
31. ter Meulen CG, van Riemsdijk I, Hene RJ, Christiaans MH, Borm GF, van Gelder T, Hilbrands LB, Weimar W, Hoitsma AJ (2004) Steroid-withdrawal at 3 days after renal transplantation with anti-IL-2 receptor alpha therapy: A prospective, randomized, multicenter study. Am J Transplant 4:803-810
32. Rostaing L, Cantarovich D, Mourad G, Budde K, Rigotti P, Mariat C, Margreiter R, Capdevilla L, Lang P, Vialtel P, Ortuno-Mirete J, Charpentier B, Legendre C, Sanchez-Plumed J, Oppenheimer F, Kessler M (2005) Corticosteroid-free immunosuppression with tacrolimus, mycophenolate mofetil, and daclizumab induction in renal transplantation. Transplantation 79:807-814
33. Vincenti F, Schena FP, Paraskevas S, Hauser IA, Walker RG, Grinyo J (2008) A randomized, multicenter study of steroid avoidance, early steroid withdrawal or standard steroid therapy in kidney transplant recipients. Am J Transplant 8:307-316
34. Sivaraman P, Nussbaumer G, Landsberg D (2001) Lack of long-term benefits of steroid withdrawal in renal transplant recipients. Am J Kidney Dis 37:1162-1169
35. Boots JM, van Duijnhoven EM, Christiaans MH, Wolffenbuttel BH, van Hooff JP (2002) Glucose metabolism in renal transplant recipients on tacrolimus: The effect of steroid withdrawal and tacrolimus trough level reduction. J Am Soc Nephrol 13:221-227
36. Midtvedt K, Hjelmesaeth J, Hartmann A, Lund K, Paulsen D, Egeland T, Jenssen T (2004) Insulin resistance after renal transplantation: The effect of steroid dose reduction and withdrawal. J Am Soc Nephrol 15:3233-3239
37. van den Ham EC, Kooman JP, Christiaans ML, van Hooff JP (2003) The influence of early steroid withdrawal on body composition and bone mineral density in renal transplantation patients. Transpl Int 16:82-87
38. Farmer CK, Hampson G, Abbs IC, Hilton RM, Koffman CG, Fogelman I, Sacks SH (2006) Late low-dose steroid withdrawal in renal transplant recipients increases bone formation and bone mineral density. Am J Transplant 6:2929-2936
39. ter Meulen CG, van Riemsdijk I, Hene RJ, Christiaans MH, Borm GF, Corstens FH, van Gelder T, Hilbrands LB, Weimar W, Hoitsma AJ (2004) No important influence of limited steroid exposure on bone mass during the first year after renal transplantation: A prospective, randomized, multicenter study. Transplantation 78:101-106
40. van den Ham EC, Kooman JP, Christiaans MH, Nieman FH, van Hooff JP (2003) Weight changes after renal transplantation: A comparison between patients on 5-mg maintenance steroid therapy and those on steroid-free immunosuppressive therapy. Transpl Int 16:300-306
41. Pascual J, Zamora J, Galeano C, Quereda C, Royuela A, Burgos FJ (2007) Steroid avoidance or very early withdrawal in kidney transplantation: A meta-analysis of randomized controlled trials. American Transplant Congress, San Francisco, USA
42. Cole EH, Johnston O, Rose C, Gill JS (2007) PTDM and acute rejection are associated with a similar risk for graft loss. American Transplant Congress, San Francisco, USA
43. Ekberg H, Tedesco-Silva H, Demirbas A, Vitko S, Nashan B, Gurkan A, Margreiter R, Hugo C, Grinyo JM, Frei U, Vanrenterghem Y, Daloze P, Halloran PF (2007) Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med 357:2562-2575
44. Woodle ES, Alloway RR, Buell JF, Alexander JW, Munda R, Roy-Chaudhury P, First MR, Cardi M, Trofe J (2005) Multivariate analysis of risk factors for acute rejection in early corticosteroid cessation regimens under modern immunosuppression. Am J Transplant 5:2740-2744
45. Matas AJ, Kandaswamy R, Gillingham KJ, McHugh L, Ibrahim H, Kasiske B, Humar A (2005) Prednisone-free maintenance immunosuppression - a 5-year experience. Am J Transplant 5:2473-2478
46. John E, Lumpaopang A, Oberholzer J, Testa G, Sankary H, Benedetti E (2005) Superior outcomes in growth and renal function with early steroid discontinuation in pediatric kidney transplantation: 1/2 years follow up. American Transplant Congress, Seattle, USA