PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis

Journal of the American Chemical Society

Volumn 130, Issue 50, 2008, Pages 17053-17061

  Ahuja, Ekta G ^a   Janning, Petra ^a   Mentel, Matthias ^b,c   Graebsch, Almut ^b   Breinbauer, Rolf ^a,b,c,d   Hiller, Wolf ^b   Costisella, Burkhard ^b   Thomashow, Linda S ^e,f   Mavrodi, Dmitri V ^e   Blankenfeldt, Wulf ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b TU DORTMUND UNIVERSITY   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^e WASHINGTON STATE UNIVERSITY   (United States)

^f AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITES; BIOLOGICAL PROCESSES; CONDENSATION PRODUCTS; CYCLOHEXENONE; DICARBOXYLIC ACIDS; DIMERIC PROTEINS; ENZYMATIC CATALYSES; IMINE FORMATIONS; IN VITRO; IN-VIVO; NEGATIVE CHARGES; OXIDATIVE DECARBOXYLATIONS; REACTIVE OXYGEN SPECIES; SECONDARY METABOLITES; TETRAHEDRAL INTERMEDIATES; TRI CYCLES; TRICYCLIC PRODUCTS;

ACIDS; AMINES; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; CARBOXYLATION; CARBOXYLIC ACIDS; CATALYSIS; CONDENSATION; METABOLITES; MOLECULAR OXYGEN; NITROGEN COMPOUNDS; NUCLEAR MAGNETIC RESONANCE; OPTICAL COMMUNICATION; ORGANIC ACIDS; OXYGEN; STRAIN;

MAGNETIC FIELD EFFECTS;

BACTERIAL PROTEINS; BIOCATALYSIS; BURKHOLDERIA CEPACIA; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; OXIDATION-REDUCTION; PHENAZINES; PROTEIN MULTIMERIZATION; PSEUDOMONAS AERUGINOSA; STEROID ISOMERASES; SUBSTRATE SPECIFICITY;

EID: 58049213855     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja806325k     Document Type: Article

References (29)

1. Fordos, J. Recl. Trav. Soc. d'Emulation Sci. Pharm. 1859, 3, 30.
2. Allen, L.; Dockrell, D. H.; Pattery, T.; Lee, D. G.; Cornelis, P.; Hellewell, P. G.; Whyte, M. K. J. Immunol. 2005, 174, 3643-3649.
3. Lau, G. W.; Hassett, D. J.; Ran, H.; Kong, F. Trends Mol. Med. 2004, 10, 599-606.
4. Heijerman, H. J. Cyst. Fibros. 2005, 4 Suppl 2, 3-5.
5. Price-Whelan, A.; Dietrich, L. E.; Newman, D. K. Nat. Chem. Biol. 2006, 2, 71-78.
6. Giddens, S. R.; Feng, Y.; Mahanty, H. K. Mol. Microbiol. 2002, 45, 769-783.
7. Cook, R. J.; Thomashow, L. S.; Weller, D. M.; Fujimoto, D.; Mazzola, M.; Bangera, G.; Kim, D. S. Proc. Natl, Acad. Sci. U.S.A. 1995, 92, 4197-4201.
8. Hernandez, M. E.; Kappler, A.; Newman, D. K. Appl. Environ. Microbiol. 2004, 70, 921-928.
9. Price-Whelan, A.; Dietrich, L. E.; Newman, D. K. J. Bacteriol. 2007, 189, 6372-6381.
10. Dietrich, L. E.; Price-Whelan, A.; Petersen, A.; Whiteley, M.; Newman, D. K. Mol. Microbiol. 2006, 61, 1308-1321.
11. Turner, J. M.; Messenger, A. J. Adv. Microb. Physiol. 1986, 27, 211-275.
12. Laursen, J. B.; Nielsen, J. Chem. Rev. 2004, 104, 1663-1686.
13. Mavrodi, D. V.; Blankenfeldt, W.; Thomashow, L. S. Annu. Rev. Phytopathol. 2006, 44, 417-445.
14. McDonald, M.; Mavrodi, D. V.; Thomashow, L. S.; Floss, H. G. J. Am. Chem. Soc. 2001, 123, 9459-9460.
15. Parsons, J. F.; Calabrese, K.; Eisenstein, E.; Ladner, J. E. Biochemistry 2003, 42, 5684-5693.
16. Blankenfeldt, W.; Kuzin, A. P.; Skarina, T.; Korniyenko, Y.; Tong, L.; Bayer, P.; Janning, P.; Thomashow, L. S.; Mavrodi, D. V. Proc. Natl. Acad Sci. U.S.A. 2004, 101, 16431-16436.
17. Parsons, J. F.; Song, F.; Parsons, L.; Calabrese, K.; Eisenstein, E.; Ladner, J. E. Biochemistry 2004, 43, 12427-12435.
18. Parsons, J. F.; Calabrese, K.; Eisenstein, E.; Ladner, J. E. Acta Crystallogr., D: Biol. Crystallogr. 2004, 60, 2110-2113.
19. Mavrodi, D. V.; Ksenzenko, V. N.; Bonsall, R. F.; Cook, R. J.; Boronin, A. M.; Thomashow, L. S. J. Bacteriol. 1998, 180, 2541-2548.
20. Mavrodi, D. V.; Bonsall, R. F.; Delaney, S. M.; Soule, M. J.; Phillips, G.; Thomashow, L. S. J. Bacteriol. 2001, 183, 6454-6465.
21. Haagen, Y.; Gluck, K.; Fay, K.; Kammerer, B.; Gust, B.; Heide, L. ChemBioChem 2006, 7, 2016-2027.
22. Ahuja, E. G.; Mavrodi, D. V.; Thomashow, L. S.; Blankenfeldt, W. Acta Crystallogr., D: Biol. Crystallogr. 2004, 60, 1129-1131.
23. Dorrestein, P.; Begley, T. P. Bioorg. Chem. 2005, 33, 136-148.
24. Kis, K.; Kugelbrey, K.; Bacher, A. J. Org. Chem. 2001, 66, 2555-2559.
25. Burgi, H. B.; Dunitz, J. D.; Lehn, J. M.; Wipff, G. Tetrahedron 1974, 30, 1563-1572.
26. Kim, S. W.; Cha, S. S.; Cho, H. S.; Kim, J. S.; Ha, N. C.; Cho, M. J.; Joo, S.; Kim, K. K.; Choi, K. Y.; Oh, B. H. Biochemistry 1997, 36, 14030-14036.
27. Doublie, S. Methods Enzymol. 1997, 276, 523-530.
28. Wolf, C.; Liu, S. L.; Mei, X. F.; August, A. T.; Casimir, M. D. J. Org. Chem. 2006, 71, 3270-3273.
29. Smallcombe, S. H.; Patt, S. L.; Keifer, P. A. J. Magn. Reson. A 1995, 117, 295-303.