Microdose follicular flare: a viable alternative for normal-responding patients undergoing in vitro fertilization?

Fertility and Sterility

Volumn 91, Issue 1, 2009, Pages 110-114

  Levens, Eric D ^a,b,c   Whitcomb, Brian W ^d   Kort, Jonathan D ^c   Materia Hoover, Donna ^e   Larsen, Frederick W ^a,b  

^a Walter Reed Army Medical Center   (Colombia)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c Reproductive Biology and Medicine Branch   (Colombia)

^d EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^e ART Institute   (Colombia)

Author keywords

assisted reproductive technology; GnRH agonist; Leuprolide acetate; microdose follicular flare

Indexed keywords

ETHINYLESTRADIOL PLUS NORGESTREL; HUMAN MENOPAUSAL GONADOTROPIN; LEUPRORELIN; LUTEINIZING HORMONE; RECOMBINANT FOLLITROPIN;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG DOSE REDUCTION; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; LIVE BIRTH; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; OOCYTE MATURATION; OOCYTE RETRIEVAL; OUTCOME ASSESSMENT; PREGNANCY; PRIORITY JOURNAL;

ADULT; CHORIONIC GONADOTROPIN; COHORT STUDIES; CORPUS LUTEUM; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO IMPLANTATION; ESTRADIOL; FEMALE; FERTILITY AGENTS, FEMALE; FERTILIZATION IN VITRO; HUMANS; INFANT, NEWBORN; LEUPROLIDE; MULTIVARIATE ANALYSIS; OOCYTE RETRIEVAL; PATIENT SELECTION; PREGNANCY; PREGNANCY OUTCOME; RETROSPECTIVE STUDIES;

EID: 58049196933     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.11.018     Document Type: Article

References (16)

1. Janssens R.M., Lambalk C.B., Vermeiden J.P., Schats R., Bernards J.M., Rekers-Mombarg L.T., et al. Dose-finding study of triptorelin acetate for prevention of a premature LH surge in IVF: a prospective, randomized, double-blind, placebo-controlled study. Hum Reprod 15 (2000) 2333-2340
2. San Roman G.A., Surrey E.S., Judd H.L., and Kerin J.F. A prospective randomized comparison of luteal phase versus concurrent follicular phase initiation of gonadotropin-releasing hormone agonist for in vitro fertilization. Fertil Steril 58 (1992) 744-749
3. Hughes E.G., Fedorkow D.M., Daya S., Sagle M.A., Van de Koppel P., and Collins J.A. The routine use of gonadotropin-releasing hormone agonists prior to in vitro fertilization and gamete intrafallopian transfer: a meta-analysis of randomized controlled trials. Fertil Steril 58 (1992) 888-896
4. Porter R.N., Smith W., Craft I.L., Abdulwahid N.A., and Jacobs H.S. Induction of ovulation for in-vitro fertilisation using buserelin and gonadotropins. Lancet 2 (1984) 1284-1285
5. van Loenen A.C., Huirne J.A., Schats R., Hompes P.G., and Lambalk C.B. GnRH agonists, antagonists, and assisted conception. Semin Reprod Med 20 (2002) 349-364
6. Gonen Y., Jacobson W., and Casper R.F. Gonadotropin suppression with oral contraceptives before in vitro fertilization. Fertil Steril 53 (1990) 282-287
7. Damario M.A., Barmat L., Liu H.C., Davis O.K., and Rosenwaks Z. Dual suppression with oral contraceptives and gonadotrophin releasing-hormone agonists improves in-vitro fertilization outcome in high responder patients. Hum Reprod 12 (1997) 2359-2365
8. Scott R.T., and Navot D. Enhancement of ovarian responsiveness with microdoses of gonadotropin-releasing hormone agonist during ovulation induction for in vitro fertilization. Fertil Steril 61 (1994) 880-885
9. Schoolcraft W., Schlenker T., Gee M., Stevens J., and Wagley L. Improved controlled ovarian hyperstimulation in poor responder in vitro fertilization patients with a microdose follicle-stimulating hormone flare, growth hormone protocol. Fertil Steril 67 (1997) 93-97
10. Detti L., Williams D.B., Robins J.C., Maxwell R.A., and Thomas M.A. A comparison of three downregulation approaches for poor responders undergoing in vitro fertilization. Fertil Steril 84 (2005) 1401-1405
11. Surrey E.S., Bower J., Hill D.M., Ramsey J., and Surrey M.W. Clinical and endocrine effects of a microdose GnRH agonist flare regimen administered to poor responders who are undergoing in vitro fertilization. Fertil Steril 69 (1998) 419-424
12. Sharara F.I., and McClamrock H.D. Use of microdose GnRH agonist protocol in women with low ovarian volumes undergoing IVF. Hum Reprod 16 (2001) 500-503
13. Leondires M.P., Escalpes M., Segars J.H., Scott Jr. R.T., and Miller B.T. Microdose follicular phase gonadotropin-releasing hormone agonist (GnRH-a) compared with luteal phase GnRH-a for ovarian stimulation at in vitro fertilization. Fertil Steril 72 (1999) 1018-1023
14. Frattarelli J.L., Levi A.J., Miller B.T., and Segars J.H. A prospective assessment of the predictive value of basal antral follicles in in vitro fertilization cycles. Fertil Steril 80 (2003) 350-355
15. Frattarelli J.L., Lauria-Costab D.F., Miller B.T., Bergh P.A., and Scott R.T. Basal antral follicle number and mean ovarian diameter predict cycle cancellation and ovarian responsiveness in assisted reproductive technology cycles. Fertil Steril 74 (2000) 512-517
16. Park W.I., Kim S.S., Chung H.R., Shin S.Y., and Lee J.Y. Early and late hormonal responses to the microdose gonadotropin-releasing hormone agonist in normal menstruating women. Fertil Steril 81 (2004) 1067-1072