Dual suppression with oral contraceptives and gonadotrophin releasing-hormone agonists improves in-vitro fertilization outcome in high responder patients

Human Reproduction

Volumn 12, Issue 11, 1997, Pages 2359-2365

  Damario, M A ^a,b   Barmat, L ^a   Liu, H C ^a   Davis, O K ^a   Rosenwaks, Z ^a  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Gonadotrophin releasing hormone agonist; High responder; In vitro fertilization; Oral contraceptives; Polycystic ovarian syndrome

Indexed keywords

ANDROSTENEDIONE; ESTRADIOL; FOLLITROPIN; GONADORELIN AGONIST; HUMAN MENOPAUSAL GONADOTROPIN; LEUPRORELIN; LUTEINIZING HORMONE; MESTRANOL PLUS NORETHISTERONE; ORAL CONTRACEPTIVE AGENT; PRASTERONE SULFATE; TESTOSTERONE; UROFOLLITROPIN;

ADULT; ANDROSTENEDIONE BLOOD LEVEL; ARTICLE; CLINICAL PROTOCOL; ESTRADIOL BLOOD LEVEL; FEMALE; FEMALE INFERTILITY; FERTILIZATION; FERTILIZATION IN VITRO; FOLLITROPIN BLOOD LEVEL; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; NIDATION; ORAL DRUG ADMINISTRATION; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; PREGNANCY RATE; RETROSPECTIVE STUDY; SUBCUTANEOUS DRUG ADMINISTRATION; TESTOSTERONE BLOOD LEVEL; TREATMENT OUTCOME;

EID: 0030730643     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/12.11.2359     Document Type: Article

References (43)

1. Adams, J., Poison, D.W., Abdulwahid, N. et al. (1985) Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotropin releasing hormone. Lancet, ii, 1375-1378.
2. Adashi, E.Y., Resnick, C.E., D'Ercole, A.J. et al. (1985) Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. Endocrinol Rev., 6, 400-420.
3. Andreani, C.L., Pierro, E., Lanzone, A. et al. (1994) Effect of gonadotropins, insulin and IGF I on granulosa luteal cells from polycystic ovaries. Mol. Cell. Endocrinol., 106, 91-97.
4. Balen, A.M., Tan, S.L., MacDougall, J. and Jacobs, H.S. (1993) Miscarriage rates following in-vitro fertilization are increased in women with polycystic ovaries and are reduced by pituitary desensitization with buserelin. Hum. Reprod., 8, 959-964.
5. Benadiva, C.A., Ben-Rafael, A., Blasco, L. et al. (1988) Ovarian response to human menopausal gonadotropin following suppression with oral contraceptives. Fertil. Steril., 50, 516-518.
6. Byme, G.C., Perry. Y.S. and Winter, J.S.D. (1986) Steroid inhibitory effects upon human adrenal 3β-hydroxysteroid dehydrogenase activity. J. Clin. Endocrinol. Metab., 62, 413-418.
7. Cedrin-Durnerin, I., Bulwa, S., Herve, F. et al. (1996) The hormonal flareup following gonadotrophin-releasing hormone agonist administration is influenced by a progestogen pretreatment. Hum. Reprod., 11, 1859-1863.
8. Chang, R.J., Nakamura, R.M., Judd, H.L. and Kaplan S.A. (1983) Insulin resistance in non-obese patients with polycystic ovarian disease. J. Clin. Endocrinol. Metab., 57, 356-359.
9. Clifford, K., Rai, R., Watson, H. el al. (1996) Does suppressing luteinising hormone secretion reduce the miscarriage rate? Results of a randomised controlled trial. Br. Med. J., 312, 1508-1511.
10. Cohen, J., Malter, H., Elsner, C. et al. (1990) Immunosuppression supports implantation of zona pellucida dissected human embryos. Fertil. Steril., 53, 662-665.
11. Cohen, J., Alikani. M., Malter, H.E. et al. (1991) Partial zona dissection or subzonal sperm insertion: micro surgi cal fertilization alternatives based on evaluation of sperm and embryo morphology. Fertil. Steril, 56, 696-706.
12. Cohen, J., Alikani, M., Trowbridge, J. and Rosenwaks, Z. (1992) Implantation enhancement by selective assisted hatching using zona drilling of embryos with poor prognosis. Hum. Reprod., 7, 685-691.
13. Dale, P.O., Ranbo, T., Lunde, O. and Abyholm, T. (1993) Ovulation induction with low dose follicle stimulating hormone in women with polycystic ovary syndrome. Acta Obstet. Gynecol. Scand., 72, 43-46.
14. Di Blasio, A.M., Vigano, P. and Ferrari, A. (1994) Insulin-like growth factorII stimulates human granulosa-luteal cell proliferation in vitro. Fertil. Steril., 61, 483-487.
15. Dor, J., Shulman, A., Levran, D. et al. (1990) The treatment of patients with polycystic ovary syndrome by in-vitro fertilization: a comparison of results with those patients with tubal infertility. Hum. Reprod., 5, 816-818.
16. Dor, J., Shulman, A., Pariente, C. et al. (1992) The effect of gonadotropinreleasing hormone agonist on the ovarian response and in vitro fertilization results in polycystic ovarian syndrome: a prospective study. Fertil. Steril., 57, 366-371.
17. Erickson, G.F., Hsueh, A.J., Quigley, M.E. et al. (1979) Functional studies of aromatase activity in human granulosa cells from normal and polycystic ovaries. J. Clin. Endocrinol. Metab., 49, 514-519.
18. Erickson, G.F., Magoffin, D.A., Cragun, J.R. and Chang, R.J. (1990) The effects of insulin and insulin-like growth factors I and II on estradiol production by granulosa cells of polycystic ovaries. J. Clin. Endocrinol. Metab., 70, 894-902.
19. Franks, S. and Mason, H.D. (1991) Polycystic ovary syndrome: interaction of follicle stimulating hormone and polypeptide growth factors in estradiol production by human granulosa cells. J. Steroid Biochem. Mol. Biol., 40, 405-409.
20. Golan, A., Ron-El, R., Herman, A. et al. (1989) Ovarian hyperstimulation syndrome: an update review. Obstet. Gynecol Surv., 44, 430-440.
21. Gonen, Y., Jacob sen, W. and Casper, R.F. (1990) Gonadotropin suppression with oral contraceptives before in vitro fertilization. Fertil. Steril., 53, 282-287.
22. Gonzalez, F., Hatala, D.A. and Speroff, L. (1991) Basal and dynamic hormonal responses to gonadotropin releasing hormone agonist treatment in women with polycystic ovaries with high and low dehydroepiandrosterone sulfate levels. Am. J. Obstet. Gynecol., 165, 535-545.
23. Hamilton-Fairley, D., Kiddy, D., Watson, H. et al. (1991) Low dose gonadotropin therapy for induction of ovulation in 100 women with polycystic ovary syndrome. Hum. Reprod., 6, 1095-1099.
24. Hamuri, M., Zwirner, M., Cledon, P. and Tinneberg, H.-R. (1992) Androgen response in polycystic ovarian syndrome to FSH treatment after LHRH agonist suppression. Int. J. Fertil., 37, 171-175.
25. Homburg, R., Levy, T., Berkovitz, D. et al. (1993) Gonadotropin-releasing hormone agonist reduces the miscarriage rate for pregnancies achieved in women with polycystic ovary syndrome. Fertil. Steril., 59, 527-531.
26. Homburg, R., Levy, T. and Ben-Rafael, Z. (1995) A comparative prospective study of conventional regimen with chronic low dose administration of follicle stimulating hormone for anovulation associated with polycystic ovary syndrome. Fertil. Steril., 63, 729-733.
27. MacDougall, M.J., Balen, A. and Jacobs, H.S. (1992) Polycystic ovaries and their relevance to assisted fertility. In Brinsden, P.R. and Rainsbury, P.A. (eds), Bourn Hall Textbook of In-vitro Fertilization and Assisted Reproduction. Parthenon Press, London, pp. 93-110.
28. Mason, H.D., Willis, D.S., Beard, R.W. et al. (1994) Estradiol production by granulosa cells of normal and polycystic ovaries: relationship to menstrual cycle history and concentrations of gonadotropins and sex steroids in follicular fluid. J. Clin. Endocrinol. Metab., 79, 1355-1360.
29. Palermo, G.D., Cohen, J., Alikani, M. et al. (1995) Intracytoplasmic sperm injection: a novel treatment for all forms of male factor infertility. Fertil. Steril., 63, 1231-1240.
30. Pasquali, R., Casimirri, F., Venturoli, S. et al. (1983) Insulin resistance in patients with polycystic ovaries: its relationship to body weight and androgen levels. Acta Endocrinol., 104, 110-116.
31. Poretsky, L. and Kalin, M.F. (1987) The gonadotrophic function of insulin. Endocrinol, Rev., 8, 132-141.
32. Regan, L., Owen, E.J. and Jacobs, H.S. (1990) Hypersecretion of luteinizing hormone, infertility and miscarriage. Lancet, 336, 1141-1144.
33. Salat-Baroux, J., Alvarez, S., Antoine, J.M. et al. (1988) Comparison between long and short protocols of LHRH agonist in the treatment of polycystic ovary disease by in-vitro fertilization. Hum. Reprod., 3, 535-539.
34. Seibel, M.M., Kamrava, M.M., McArdle, C. and Taymor, M.L. (1984) Treatment of polycystic ovarian disease with chronic low dose follicle stimulating hormone: biochemical changes and ultrasound correlation. Int. J. Fertil., 29, 39-43.
35. Shoham, Z., Patel, A. and Jacobs, H.S. (1991) Polycystic ovary syndrome: safety and effectiveness of stepwise and low dose administration of purified follicle stimulating hormone. Fertil. Steril., 55, 1051-1056.
36. Smitz, J., Camus, M., Devroey, P. et al. (1990) Incidence of severe ovarian hyperstimulation syndrome after gonadotrophin releasing hormone agonist/ HMG superovulation for in-vitro fertilization. Hum. Reprod., 5, 933-937.
37. Stanger, J.D. and Yovich, J.L. (1985) Reduced in-vitro fertilization of human oocytes from patients with raised basal luteinizing hormone levels during the follicular phase. Br. J. Obstet. Gynaecol., 92, 385-393.
38. Suikkari, A.M., MacLachlan, V., Montalto, J. et al. (1995) Ultrasonographic appearance of polycystic ovaries is associated with exaggerated ovarian androgen and estradiol responses to gonadotrophin-releasing hormone agonist in women undergoing assisted reproduction treatment. Hum. Reprod., 10, 513-519.
39. Tanbo, T., Abyholm, T., Magnus, O. and Henriksen, T. (1989) Gonadotropin and ovarian production in polycystic ovarian syndrome during suppression with a gonadotropin-releasing hormone agonist. Gynecol. Obstet. Invest., 28, 147-151.
40. Tarlatzis, B.C., Grimbizis, G., Pournaropoulos, F. et al. (1995) The prognostic value of basal luteinizing hormone: follicle-stimulating hormone ratio in the treatment of patients with polycystic ovarian syndrome by assisted reproduction techniques. Hum Reprod., 10, 2545-2549.
41. Urman, B., Fluker, M.R., Ho Yuen, B. et al. (1992) The outcome of in vitro fertilization and embryo transfer in women with polycystic ovary syndrome failing to conceive after ovulation induction with exogenous gonadotropins. Fertil. Steril., 57, 1269-1273.
42. Wang, C.F. and Gemzell, C. (1980) The use of human gonadotropin for the induction of ovulation in women with polycystic ovarian disease. Fertil. Steril., 33, 479-486.
43. Wong, I.L., Morris, R.S., Lobo, R.A. et al. (1995) Isolated polycystic morphology in ovum donors predicts response to ovarian stimulation. Hum. Reprod., 10, 524-528.