Long-term caffeine consumption reverses tumor-induced suppression of the innate immune response in adult mice

Planta Medica

Volumn 74, Issue 15, 2008, Pages 1779-1784

  Mandal, Anup ^a   Poddar, Mrinal K ^a  

^a UNIVERSITY OF CALCUTTA   (India)

Author keywords

Caffeine; Ehrlich ascites carcinoma cell; Hormonal system; Inflammation; Innate immune response; Total and differential blood cell counts

Indexed keywords

CAFFEINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; COFFEE; CONTROLLED STUDY; DRUG MECHANISM; EHRLICH ASCITES TUMOR; FEMALE; FOOD INTAKE; IMMUNE RESPONSE; IMMUNOREGULATION; IMMUNOSTIMULATION; IN VIVO STUDY; INNATE IMMUNITY; LONG TERM EXPOSURE; MOUSE; NONHUMAN; PARAMETER; TEA; TUMOR GROWTH;

ANIMALS; BLOOD CELL COUNT; BLOOD SEDIMENTATION; BODY WEIGHT; CAFFEINE; CAMELLIA SINENSIS; CARCINOMA, EHRLICH TUMOR; COFFEA; DISEASE MODELS, ANIMAL; FEMALE; HEMATOCRIT; HEMOGLOBINS; IMMUNITY, INNATE; IMMUNOLOGIC FACTORS; MICE; PHYTOTHERAPY;

CAMELLIA SINENSIS; COFFEA ARABICA; MUS;

EID: 58049195139     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0028-1088337     Document Type: Article

References (27)

1. Rates SM. Plants as source of drugs. Toxicon 2001; 39: 603-13
2. Di Carlo G, Mascolo N, Izzo AA, Capassao F. Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sci 1999; 65: 337-53
3. Fisone G, Borqkvist A, Usiello A. Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci 2004; 61: 857-72
4. Mukhopadhyay S, Poddar MK. Long-term caffeine inhibits Ehrlich ascites carcinoma cell-induced induction of central GABAergic activity. Neurochem Res 2000; 25: 1457-63
5. Mukhopadhyay S, Mondal A, Poddar MK. Chronic administration of caffeine: effect on the activities of hepatic antioxidant enzymes of Ehrlich ascites tumor-bearing mice. Indian J Exp Biol 2003; 41: 283-9
6. Mandal A, Batabyal SK, Poddar MK. Long-term caffeine-induced inhibition of EAC cell progression in relation to gonadal hormone status. Indian J Exp Biol 2007; 45: 347-52
7. Theiss JC, Shimkim MB. Inhibiting effect of caffeine on spontaneous and urethane-induced lung tumors in strain A mice. Cancer Res 1978; 38: 1757-61
8. VanderPloeg LC, Welsch CW. Inhibition by caffeine of ovarian hormone-induced mammary gland tumorigenesis in female GR mice. Cancer Lett 1991; 56: 245-50
9. Gilbert RM. Caffeine consumption. In: Spiller GA, editor. The methylxanthine beverages and foods: chemistry, consumption, and health effects. New York: Liss; 1984: 108-24
10. Mandal A, Poddar MK. Does caffeine reverse the EAC cell-induced immune suppression? J Pharm Pharmacol 2007; 59: 1001-9
11. Parkin J, Cohen B. An overview of the immune system. Lancet 2001; 357: 1777-89
12. Sternberg EM. Natural regulation of innate immunity: a coordinated non-specific host response to pathogens. Nat Rev Immunol 2006; 6: 318-28
13. Sternberg EM, Hill JM, Chrousos GP, Kamilaris T, Listwak SJ, Gold PW et al. Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats. Proc Natl Acad Sci USA 1989; 86: 2374-8
14. Gomez SA, Fernández GC, Vanzulli S, Dran G, Rubel C, Berki T et al. Endogenous glucocorticoids attenuate Shiga toxin-2-induced toxicity in a mouse model of haemolytic uraemic syndrome. Clin Exp Immunol 2003; 131: 217-24
15. Modha K, Whiteside JP, Spir RE. The determination of cellular viability of hybridoma cells in microtitre plate: a colorimetric assay based on neutral red. Cytotechnology 1993; 13: 227-32
16. D'Armour FE, Blood FR, Belden DA. The manual for laboratory work in mammalian physiology, 3 rd edition. Chicago: The University of Chicago Press ; 1965: 4-6
17. Dacie JV, Lewis SM. Practical hematology, 2nd edition. London: J and A Churchill; 1958:38-48
18. Segura JA, Barbero LG, Marquez J. Ehrlich ascites tumour unbalances splenic cell population and reduces responsiveness of T cells to Staphylococcus aureus enterotoxin B stimulation. Immunol Lett 2000; 74: 11-5
19. Holtzman SG, Finn IB. Tolerance to behavioral effects of caffeine in rats. Pharmacol Biochem Behav 1988; 29: 411-8
20. Mukhopadhyay S, Poddar MK. Is GABA involved in the development of caffeine tolerance? Neurochem Res 1998; 23: 63-8
21. De Vita VT Jr, Hellman S, Rosenberg SA. Cancer: principle and practice of oncology, 4th edition. Philadelphia: J.B. Lippincott Company; 1993
22. Dan Rutherford GP, Green R. Cancer and anaemia. Health advise online. Available at http://www.tiscali.co.uk/lifestyle/healthfitness/ health_advice/netdoctor/archieve/002208.html. Accessed March 7, 2008
23. White blood cell differential count, Understanding your test. Lab tests online. Available at http://www.labtestsonline.org/understanding/analytes/ differential/test.html. Accessed March 8, 2008
24. Medicine plus: Medical encyclopedia online. Available at http://www.nlm.nih.gov/medlineplus/ency/article/003638.htm. Accessed March 8, 2008
25. Dongre SH, Badami S, Natesan S HRC. Antitumor activity of methanol extract of Hypericum hookerianum stem against Ehrlich Ascites Carcinoma in Swiss albino mice. J Pharmacol Sci 2007; 103: 354-9
26. Gupta M, Mazumder UK, Sambath Kumar R, Shivakumar T, Vamsi MLM. Antitumor activity and antioxidant status of Caesapinia bonducella against Ehrlich ascites carcinoma in Swiss albino mice. J Pharmacol Sci 2004; 94: 177-84
27. Casas M, Prat G, Robledo P, Barbanoj M, Kulisevsky J, Jane F. Repeated co-administration of caffeine and bromocriptine prevents tolerance to the effects of caffeine in the turning behavior animal model. Eur Neuropsychopharmacol 1999; 9: 515-21