Effects of ethanol treatment on the neurogenic- and endothelium-dependent relaxation of corpus cavernosum smooth muscle in the mouse

Pharmacological Reports

Volumn 60, Issue 5, 2008, Pages 725-734

  Aydinoglu, Fatma ^a   Yilmaz, Sakir N ^b   Coskun, Banu ^b   Daglioglu, Nebile ^a   Ogulener, Nuran ^a  

^a CUKUROVA UNIVERSITY FACULTY OF MEDICINE   (Turkey)

^b MERSIN UNIVERSITY   (Turkey)

Author keywords

Corpus cavernosum; Endothelium; Ethanol; Neurogenic and endothelium dependent relaxation; Nitric oxide

Indexed keywords

ACETYLCHOLINE; ALCOHOL; ENDOTHELIUM DERIVED RELAXING FACTOR; GUANYLATE CYCLASE INHIBITOR; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE DONOR; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG MECHANISM; ELECTRON MICROSCOPY; ELECTROSTIMULATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ERECTILE DYSFUNCTION; MALE; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; SMOOTH MUSCLE RELAXATION; SWISS WEBSTER MOUSE;

EID: 57849153948     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Andersson KE: Erectile physiological and pathophysiological pathways involved in erectile dysfunction. J Urol, 2003, 170, s6-s14.
2. Andersson KE, Wagner G: Physiology of penile erection. Physiol Rev, 1995, 75, 191-236.
3. Aufrére G, Bourhis B, Beaugé F: Ethanol intake after chronic intoxication by inhalation of ethanol vapour in rats: behavioural dependence. Alcohol, 1997, 14, 247-253.
4. Azadzoi KM, Goldstein I, Siroky MB, Traish AM, Krane RJ, Saenz de Tejada I: Mechanisms of ischemia-induced cavernosal smooth muscle relaxation impairment in a rabbit model of vasculogenic erectile dysfunction. J Urol, 1998, 160, 2216-2222.
5. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA: Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A, 1990, 87, 1620-1624.
6. Burnett AL: Nitric oxide in the penis: physiology and pathology. J Urol, 1997, 157, 320-324.
7. Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Synder SH: Nitric oxide: a physiologic mediator of penile erection. Science, 1992, 257, 401-403.
8. Burnett AL, Nelson RJ, Calvin DC, Liu JX, Demas GE, Klein SL, Kriegsfeld LJ et al.: Nitric oxide-dependent penile erection in mice lacking neuronal nitric oxide synthase. Mol Med, 1996, 2, 288-296.
9. Cocks TM, Angus JA: Comparison of relaxation responses of vascular and non-vascular smooth muscle to endothelium-derived relaxing factor (EDRF), acidified sodium nitrite (NO) and sodium nitroprusside. Naunyn Schmiedebergs Arch Pharmacol, 1990, 341, 364-372.
10. Creager MA, Cooke JP, Mendelshon ME, Gallagher SJ, Coleman SM, Loscalzo J, Dzau VJ: Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest, 1990, 86, 228-234.
11. Croft KD, Puddey IB, Rakic V, Abu-Amsha R, Dimmitt SB, Beilin LJ: Oxidative susceptibility of low-density lipoproteins: influence of regular alcohol use. Alcohol Clin Exp Res, 1996, 20, 980-984.
12. Dahchour A, De Witte P: Excitatory and inhibitory amino acid changes during repeated episodes of ethanol withdrawal: an in vivo microdialysis study. Eur J Pharmacol, 2003, 459, 171-178.
13. Ghadially FN: REF: Ultrastructural Pathology of the Cell and Matrix, 4th edn. Butterworth-Heinemann, Boston, 1997. Vol. 1, Chapter 1 (Nucleus), 2-10.
14. Gocmen C, Gokturk HS, Ucar PE, Onder S, Dikmen A, Baysal F: Effect of neocuproine, a selective Cu(I) chelator, on nitrergic relaxations in the mouse corpus cavernosum. Eur J Pharmacol, 2000, 406, 293-300.
15. Gocmen C, Secilmis A, Kumcu EK, Ucar PE, Onder S, Dikmen A, Baysal F: Effects of vitamin E and sodium selenate on neurogenic and endothelial relaxation of corpus cavernosum in the diabetic mouse. Eur J Pharmacol, 2000, 398, 93-98.
16. Gocmen C, Ucar P, Singirik E, Dikmen A, Baysal F: An in vitro study of nonadrenergic-noncholinergic activity on the cavernous tisssue of mouse. Urol Res, 1997, 25, 269-275.
17. Goldstein DB, Pal N: Alcohol dependence produced in mice by inhalation of ethanol: grading the withdrawal reaction. Science, 1971, 172, 288-290.
18. Grattagliano I, Vendemiale G, Sabbà C, Buonamico P, Altomare E: Oxidation of circulating proteins in alcoholics: role of acetaldehyde and xanthine oxidase. J Hepatol, 1996, 25, 28-36.
19. Hatake K, Wakabayashi I, Taniguchi T, Hishida S: Increased endothelium-dependent vascular relaxation in ethanol-fed rats. Alcohol Clin Exp Res, 1994, 18, 1018-1023.
20. Hedlund P, Aszodi A, Pfeifer A, Alm P, Hofmann F, Ahmad M, Fassler R et al.: Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. Proc Natl Acad Sci U S A, 2000, 97, 2349-2354.
21. Husain K, Mejia J, Lalla J, Kazim S: Dose response of alcohol-induced changes in BP, nitric oxide and antioxidants in rat plasma. Pharmacol Res, 2005, 51, 337-343.
22. Husain K, Vazquez OM, Lalla J: Physical training ameliorates chronic alcohol-induced hypertension and aortic reactivity in rats. Alcohol Alcohol, 2006, 41, 247-253.
23. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G: Endothelium-derived relaxing factor produced and released artery and vein is nitric oxide. Proc Natl Acad Sci U S A, 1987, 84, 9265-9269.
24. Johnson ME, Sill JC, Brown DL, Halsey TJ, Uhl CB: The effect of the neurolytic agent ethanol on cytoplasmic calcium in arterial smooth muscle and endothelium. Reg Anesth, 1996, 21, 6-13.
25. Kim N, Azadzoi KM, Goldstein I, Saenz de Tejada I: A nitric oxide-like factor mediates nonadrenergicnoncholinergic relaxation of penile corpus cavernosum smooth muscle. J Clin Invest, 1991, 88, 112-118.
26. Knispel HH, Goessl C, Beckmann R: Basal and acetylcholine-stimulated nitric oxide formation mediates relaxation of rabbit cavernous smooth muscle. J Urol, 1991, 146, 1429-1433.
27. Knych ET: Endothelium-dependent transfer of ethanol tolerance in the aorta. Life Sci, 1987, 40, 1903-1908.
28. Mizusawa H, Hedlund P, Hakansson A, Alm P, Andersson KE: Morphological and functional in vitro and in vivo characterization of the mouse corpus cavernosum. Br J Pharmacol, 2001, 132, 1333-1341.
29. NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence 1993. JAMA, 270, 83-90.
30. Okamura T, Ayajiki K, Fujioka H, Toda M, Fujimiya M, Toda N: Effects of endothelial impairment by saponin on the responses to vasodilators and nitrergic nerve stimulation in isolated canine corpus cavernosum. Br J Pharmacol, 1999, 127, 802-808.
31. Pal N, Alkana RL: Use of inhalation to study the effect of ethanol and ethanol dependence on neonatal mouse development without maternal separation: a preliminary study. Life Sci, 1997, 61, 1269-1281.
32. Palmer RM, Ferrige AG, Moncada S: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor Nature. 1987, 327, 524-526.
33. Peterson TE, Poppa V, Ueba H, Wu A, Yan C, Berk BC: Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae. Circ Res, 1999, 85, 29-37.
34. Pickard RS, King P, Zar MA, Powell PH: Corpus cavernosal relaxation in impotent men. Br J Urol, 1994, 74, 485-491.
35. Pinardi G, Brieva R, Vinet R, Penna M: Effects of chronic ethanol consumption on alpha-adrenegic-induced contractions in rat thoracic aorta. Gen Pharmacol, 1992, 23, 245-248.
36. Puddey IB, Zilkens RR, Croft KD, Beilin LJ: Alcohol and endothelial function: a brief review. Clin Exp Pharmacol Physiol, 2001, 28, 1020-1024.
37. Rand MJ, Li CG: Nitric oxide as a neurotransmitter in peripheral nerves: nature of transmitter and mechanism of transmission. Annu Rev Physiol, 1995, 57, 659-682.
38. Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA: Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med, 1989, 320, 1025-1030.
39. Saito M, Broderick GA, Wein AJ, Levin RM: Effect of chronic ethanol consumption on the pharmacological response of the rabbit corpus cavernosum. Pharmacology, 1994, 49, 386-391.
40. Slomiany BL, Piotrowski J, Slomiany A: Alterations in buccal mucosal endothelin-1 and nitric oxide synthase with chronic alcohol ingestion. Biochem Mol Biol Int, 1998, 45, 681-688.
41. Strickland JA and Wooles WA: Effects of acute and chronic ethanol on the agonist responses of vascular smooth muscle. Eur J Pharmacol, 1988, 152, 83-91.
42. Sun H, Mayhan WG: Temporal effect of alcohol consumption reactivity of pial arterioles: role of oxygen radicals. Am J Physiol Heart Circ Physiol, 2001, 280, H992-H1001.
43. Tirapelli CR, Al-Khoury J, Bkaily G, D'Orléans-Juste P, Lanchote VL, Uyemura SA, de Oliveira AM: Chronic ethanol consumption enhances phenylephrine-induced contraction in the isolated rat aorta. J Pharmacol Exp Ther, 2006, 316, 233-241.
44. Williams SP, Adams RD, Mustafa SJ: The effects of chronic ethanol treatment on endothelium-dependent responses in rat thoracic aorta. Alcohol, 1990, 7, 121-127.
45. Zhang A, Altura BT, Altura BM: Ethanol-induced contraction of cerebral arteries in diverse mammals and its mechanism of action. Eur J Pharmacol, 1993, 248, 229-236.