Potent benzimidazolone-based CGRP receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 23, 2008, Pages 6122-6125

  Theberge, Cory R ^a   Bednar, Rodney A ^a   Bell, Ian M ^a   Corcoran, Halea A ^a   Fay, John F ^a   Hershey, James C ^a   Johnston, Victor K ^a   Kane, Stefanie A ^a   Mosser, Scott ^a   Salvatore, Christopher A ^a   Williams, Theresa M ^a   Zartman, C Blair ^a   Zhang, Xu Fang ^a   Graham, Samuel L ^a   Vacca, Joseph P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Benzimidazole; CGRP; Migraine; Spirohydantoin

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; CAPSAICIN; CYCLIC AMP;

ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LASER DOPPLER FLOWMETRY; NONHUMAN; REACTION ANALYSIS; RECEPTOR BLOCKING; RHESUS MONKEY; SERUM; STRUCTURE ACTIVITY RELATION; VASODILATATION;

ANIMALS; BENZIMIDAZOLES; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; INDANS; MACACA MULATTA; MOLECULAR STRUCTURE; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 55549139050     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.019     Document Type: Article

References (14)

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