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Longer reaction times led to the formation of some of the trisubstituted product
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Longer reaction times led to the formation of some of the trisubstituted product.
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More commonly, such materials are prepared through the anchorage of the fluorous material onto the preformed activated silica gel. The method, however, failed to achieve sufficient loading when applied to 6b. For some examples, see: Glatz, H.; Blay, C.; Engelhardt, H.; Bannwarth, W. Chromatographia 2004, 59, 567, and references therein.
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More commonly, such materials are prepared through the anchorage of the fluorous material onto the preformed activated silica gel. The method, however, failed to achieve sufficient loading when applied to 6b. For some examples, see: Glatz, H.; Blay, C.; Engelhardt, H.; Bannwarth, W. Chromatographia 2004, 59, 567, and references therein.
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6 with MeOH, the addition of NaOAc has been found to favor the precipitaion of Pd° in the form of nanoparticles. See reference 14.
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