Anabolic steroids in COPD: A review and preliminary results of a randomized trial

Chronic Respiratory Disease

Volumn 5, Issue 3, 2008, Pages 169-176

  Sharma, S ^a   Arneja, A ^a   McLean, L ^a   Duerksen, D ^a   Leslie, W ^a   Sciberras, D ^a   Lertzman, M ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Anabolic steroids; COPD; Muscle wasting; Nandrolone decanoate; Weight gain

Indexed keywords

DECADUARBOLIN; NANDROLONE DECANOATE; PLACEBO; UNCLASSIFIED DRUG;

ADULT; AGED; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LEAN BODY WEIGHT; MALE; NUTRITIONAL ASSESSMENT; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; REVIEW; SIDE EFFECT; UNSPECIFIED SIDE EFFECT; WEIGHT GAIN;

AGED; ANABOLIC AGENTS; ANALYSIS OF VARIANCE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; NANDROLONE; PLACEBOS; PROSPECTIVE STUDIES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; QUALITY OF LIFE; RESPIRATORY FUNCTION TESTS; TREATMENT OUTCOME; WEIGHT GAIN;

EID: 57849102724     PISSN: 14799723     EISSN: 14799731     Source Type: Journal    
DOI: 10.1177/1479972308092350     Document Type: Review

References (24)

1. Wilson DO Rogers RM Wright E Anthonisen NR. Body weight in chronic obstructive pulmonary disease. Am Rev Respir Dis 1989 ; 139: 1435 - 1438.
2. Engelen MAM Schols AMWJ Baken WC Wesseling GJ Wouters EFM. Nutritional depletion in relation to respiratory and peripheral skeletal muscle function in an outpatient population with chronic obstructive pulmonary disease. Eur Respir J 1994 ; 7: 1793 - 1797.
3. Vandenbergh E Van de Woestijne KP Gyselen A. Weight changes in the terminal stages of chronic obstructive pulmonary disease. Am Rev Respir Dis 1967 ; 95: 556 - 566.
4. Laaban JP Kouchakju B Dore MF Orvoen-Frija E David P Rochemaure J. Nutritional status of patients with chronic obstructive pulmonary disease and acute respiratory failure. Chest 1993 ; 103: 1362 - 1368.
5. Gray-Donald K Gibbons L Shapiro SH Macklem PT Martin JG. Nutritional status and mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996 ; 153: 961 - 966.
6. O'Donnell DE Hernandez P Kaplan A Aaron S Bourbeau J Marciniuk D. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2008. Can Respir J 2008 ; 15: 5B - 32B.
7. Schols AMWJ Mostert R Soeters PB Wouters EFM. Body composition and exercise performance in chronic obstructive pulmonary disease. Thorax 1991 ; 46: 695 - 699.
8. Schols AMWJ Mostert R Soeters PB Saris WHM Wouters EFM. Energy balance in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 1991 ; 143: 1248 - 1252.
9. Rogers RM Donahoe M Costantino J. Physiologic effects of oral supplemental feeding in malnourished patients with chronic obstructive pulmonary disease: a randomized control study. Am Rev Respir Dis 1992 ; 146: 1511 - 1517.
10. Lewis MI Belman MJ Dorr-Uyemura L. Nutritional supplementation of ambulatory patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 1987 ; 135: 1062 - 1068.
11. Knowles JB Farbarne MS Wiggs DJ Chan-Yan C Pardy RL. Dietary supplementation and respiratory muscle performance in patients with COPD. Chest 1998 ; 93: 977 - 983.
12. Goldstein SA Thomashow BM Kvetan V Askanazi J Kinney JM Elwy DH. Nitrogen and energy relationships in malnourished patients with emphysema. Am Rev Respir Dis 1998 ; 138: 636 - 644.
13. Efthimiou J Fleming J Gomes C Spiro SG. The effect of supplementary oral nutrition in poorly nourished patients with chronic obstructive pulmonary disease: a randomized control study. Am Rev Respir Dis 1988 ; 137: 1075 - 1082.
14. Vadasz I. Nandrolone decanoate on some forms of pulmonary tuberculosis. Arzneimittelforschung 1969 ; 19: 100 - 103.
15. 15 Schizgal HM. Anabolic steroids and parenteral nutrition. Wein Med Wochenschr 1993 ; 143: 375 - 380.
16. Schols AMWJ Soeters PB Mostert R Pluymers RJ Wouters EF. Physiologic effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease: a placebo-controlled randomized trial. Am J Resp Crit Care Med 1995 ; 152: 1268 - 1274.
17. Ferreira IM Verreschi ITV Nery LE Goldstein RS Zamel N Brooks D. The influence of 6 months of oral anabolic steroids on body mass and respiratory muscles in undernourished COPD patients. Chest 1998 ; 114: 19 - 28.
18. Yeh SS DeGuzman B Kramer T. Reversal of COPD-associated weight loss using the anabolic agent oxandrolone. Chest 2002 ; 122: 421 - 428.
19. Creutzberg EC Wouters EFM Mostert R Pluymers RJ Schols MWJ. A role for anabolic steroids in the rehabilitation of patients with COPD? A double blind, placebo controlled randomized trial. Chest 2003 ; 124: 1733 - 1742.
20. Debigare R Marquis K Cote CH Tremblay RR Michaud A LeBlanc P. Catabolic/anabolic balance and muscle wasting in patients with COPD. Chest 2003 ; 124: 83 - 89.
21. Casaburi R Bhasin S Cosentino L Porszasz J Somfay A Lewis MI. Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2004 ; 170: 870 - 878.
22. Ries AL Bauldoff GS Carlin BW Casaburi R Emery CF Mahler DA. Pulmonary Rehabilitation - Joint ACCP/AACVPR Evidence-Based Clinical Practice Guidelines. Chest 2007 ; 131: 4S - 42S.
23. Puhan MA Schünemann HJ Frey M Bachmann LM. Value of supplemental interventions to enhance the effectiveness of physical exercise during respiratory rehabilitation in patients with COPD: a systematic review. Respir Res 2004 ; 5: 25 - 36.
24. Brooks D Sottana R Bell B Hanna M Laframboise L Selvanayagarajah S. Characterization of pulmonary rehabilitation programs in Canada in 2005. Can Respir J. 2007 ; 14: 87 - 92.