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Volumn 65, Issue 1, 2009, Pages 97-100

Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2D6;

EID: 57849102018     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-008-0559-6     Document Type: Letter
Times cited : (18)

References (9)
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    • Effect of propiverine on cytochrome P450 enzymes: A cocktail interaction study in healthy volunteers
    • D Tomalik-Scharte A Jetter M Kinzig-Schippers 2005 Effect of propiverine on cytochrome P450 enzymes: a cocktail interaction study in healthy volunteers Drug Metab Dispos 33 1859 1866
    • (2005) Drug Metab Dispos , vol.33 , pp. 1859-1866
    • Tomalik-Scharte, D.1    Jetter, A.2    Kinzig-Schippers, M.3
  • 3
    • 45549095805 scopus 로고    scopus 로고
    • Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients
    • C Wyen U Fuhr D Frank 2008 Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients Clin Pharmacol Ther 84 75 82
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 75-82
    • Wyen, C.1    Fuhr, U.2    Frank, D.3
  • 4
    • 38349132802 scopus 로고    scopus 로고
    • The CYP2D6 activity score: Translating genotype information into a qualitative measure of phenotype
    • A Gaedigk SD Simon RE Pearce 2008 The CYP2D6 activity score: Translating genotype information into a qualitative measure of phenotype Clin Pharmacol Ther 83 234 242
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 234-242
    • Gaedigk, A.1    Simon, S.D.2    Pearce, R.E.3
  • 5
    • 0034663081 scopus 로고    scopus 로고
    • The decreased in vivo clearance of CYP2D6 substrates by CYP2D6*10 might be caused not only by the low-expression but also by low affinity of CYP2D6
    • T Fukuda Y Nishida S Imaoka 2000 The decreased in vivo clearance of CYP2D6 substrates by CYP2D6*10 might be caused not only by the low-expression but also by low affinity of CYP2D6 Arch Biochem Biophys 380 303 308
    • (2000) Arch Biochem Biophys , vol.380 , pp. 303-308
    • Fukuda, T.1    Nishida, Y.2    Imaoka, S.3
  • 6
    • 3543014421 scopus 로고    scopus 로고
    • A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects
    • S Raimundo C Toscano K Klein 2004 A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects Clinical Pharmacol Ther (CPT) 76 128 138
    • (2004) Clinical Pharmacol Ther (CPT) , vol.76 , pp. 128-138
    • Raimundo, S.1    Toscano, C.2    Klein, K.3
  • 7
    • 34547165040 scopus 로고    scopus 로고
    • Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17
    • H Shen MM He H Liu 2007 Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17 Drug Metab Dispos 35 1292 1300
    • (2007) Drug Metab Dispos , vol.35 , pp. 1292-1300
    • Shen, H.1    He, M.M.2    Liu, H.3
  • 8
    • 33749017640 scopus 로고    scopus 로고
    • Sequence-based analysis of the CYP2D6*36-CYP2D6*10 tandem-type arrangement, a major CYP2D6*10 haplotype in the Japanese population
    • A Soyama Y Saito T Kubo 2006 Sequence-based analysis of the CYP2D6*36-CYP2D6*10 tandem-type arrangement, a major CYP2D6*10 haplotype in the Japanese population Drug Metab Pharmacokinet 21 208 216
    • (2006) Drug Metab Pharmacokinet , vol.21 , pp. 208-216
    • Soyama, A.1    Saito, Y.2    Kubo, T.3
  • 9
    • 33749005081 scopus 로고    scopus 로고
    • Impaired expression of CYP2D6 in intermediate metabolizers carrying the*41 allele caused by the intronic SNP 2988G>A: Evidence for modulation of splicing events
    • C Toscano K Klein J Blievernicht 2006 Impaired expression of CYP2D6 in intermediate metabolizers carrying the*41 allele caused by the intronic SNP 2988G>A: evidence for modulation of splicing events Pharmacogenet Genomics 16 755 766
    • (2006) Pharmacogenet Genomics , vol.16 , pp. 755-766
    • Toscano, C.1    Klein, K.2    Blievernicht, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.