Latexin is involved in bone morphogenetic protein-2-induced chondrocyte differentiation

Biochemical and Biophysical Research Communications

Volumn 378, Issue 3, 2009, Pages 600-604

  Kadouchi, Ichiro ^a,b   Sakamoto, Kei ^b   Tangjiao, Liu ^b,c   Murakami, Takashi ^a   Kobayashi, Eiji ^a   Hoshino, Yuichi ^a   Yamaguchi, Akira ^b,d  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c DALIAN MEDICAL UNIVERSITY   (China)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

BMP 2; Bone fracture; Bone regeneration; Cartilage; Chondrocyte; Latexin

Indexed keywords

AGGRECAN; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN 2A1; COLLAGEN TYPE 10; COLLAGEN TYPE 10A1; COLLAGEN TYPE 2; ENZYME INHIBITOR; LATEXIN; MESSENGER RNA; PROTEIN AGGRECAN 1; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE REMODELING; CARTILAGE CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; FRACTURE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGGRECANS; ANIMALS; ANTIGENS; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; CELL DIFFERENTIATION; CELL LINE; CHONDROCYTES; COLLAGEN TYPE II; COLLAGEN TYPE X; EMBRYO, MAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; MICE, INBRED STRAINS; OSTEOGENESIS; PROMOTER REGIONS, GENETIC; SKELETON; SOX9 TRANSCRIPTION FACTOR;

MAMMALIA;

EID: 57849091287     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.11.111     Document Type: Article

References (26)

1. Yamaguchi A., Komori T., and Suda T. Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr. Rev. 21 (2000) 393-411
2. Lee K.S., Kim H.J., Li Q.L., Chi X.Z., Ueta C., Komori T., Wozney J.M., Kim E.G., Choi J.Y., Ryoo H.M., and Bae S.C. Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol. Cell. Biol. 20 (2000) 8783-8792
3. Lee M.H., Kim Y.J., Kim H.J., Park H.D., Kang A.R., Kyung H.M., Sung J.H., Wozney J.M., and Ryoo H.M. BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression. J. Biol. Chem. 278 (2003) 34387-34394
4. Zehentner B.K., Dony C., and Burtscher H. The transcription factor Sox9 is involved in BMP-2 signaling. J. Bone Miner. Res. 14 (1999) 1734-1741
5. Goldring M.B., Tsuchimochi K., and Ijiri K. The control of chondrogenesis. J. Cell Biochem. 97 (2006) 33-44
6. Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., Shimizu Y., Bronson R.T., Gao Y.H., Inada M., Sato M., Okamoto R., Kitamura Y., Yoshiki S., and Kishimoto T. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89 (1997) 755-764
7. Ducy P., Zhang R., Geoffroy V., Ridall A.L., and Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89 (1997) 747-754
8. Yoshida C.A., Furuichi T., Fujita T., Fukuyama R., Kanatani N., Kobayashi S., Satake M., Takada K., and Komori T. Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat. Genet. 32 (2002) 633-638
9. Akiyama H. Control of chondrogenesis by the transcription factor Sox9. Mod. Rheumatol. 18 (2008) 213-219
10. Liu T., Gao Y., Sakamoto K., Minamizato T., Furukawa K., Tsukazaki T., Shibata Y., Bessho K., Komori T., and Yamaguchi A. BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines. J. Cell Physiol. 211 (2007) 728-735
11. Arimatsu Y. Latexin: a molecular marker for regional specification in the neocortex. Neurosci. Res. 20 (1994) 131-135
12. Liang Y., and Van Zant G. Aging stem cells, latexin, and longevity. Exp. Cell. Res. 314 (2008) 1962-1972
13. Liang Y., Jansen M., Aronow B., Geiger H., and Van Zant G. The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice. Nat. Genet. 39 (2007) 178-188
14. Balint E., Lapointe D., Drissi H., van der Meijden C., Young D.W., van Wijnen A.J., Stein J.L., Stein G.S., and Lian J.B. Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation. J. Cell Biochem. 89 (2003) 401-426
15. Katagiri T., Yamaguchi A., Komaki M., Abe E., Takahashi N., Ikeda T., Rosen V., Wozney J.M., Fujisawa-Sehara A., and Suda T. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J. Cell Biol. 127 (1994) 1755-1766
16. Uratani Y., Takiguchi-Hayashi K., Miyasaka N., Sato M., Jin M., and Arimatsu Y. Latexin, a carboxypeptidase A inhibitor, is expressed in rat peritoneal mast cells and is associated with granular structures distinct from secretory granules and lysosomes. Biochem. J. 346 Pt 3 (2000) 817-826
17. Hatanaka Y., Uratani Y., Takiguchi-Hayashi K., Omori A., Sato K., Miyamoto M., and Arimatsu Y. Intracortical regionality represented by specific transcription for a novel protein, latexin. Eur. J. Neurosci. 6 (1994) 973-982
18. Akiyama H., Chaboissier M.C., Martin J.F., Schedl A., and de Crombrugghe B. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 16 (2002) 2813-2828
19. Furumatsu T., Tsuda M., Yoshida K., Taniguchi N., Ito T., Hashimoto M., and Asahara H. Sox9 and p300 cooperatively regulate chromatin-mediated transcription. J. Biol. Chem. 280 (2005) 35203-35208
20. Ikeda T., Kamekura S., Mabuchi A., Kou I., Seki S., Takato T., Nakamura K., Kawaguchi H., Ikegawa S., and Chung U.I. The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis. Rheum. 50 (2004) 3561-3573
21. Han Y., and Lefebvre V. L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Mol. Cell. Biol. 28 (2008) 4999-5013
22. Aagaard A., Listwan P., Cowieson N., Huber T., Ravasi T., Wells C.A., Flanagan J.U., Kellie S., Hume D.A., Kobe B., and Martin J.L. An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1. Structure 13 (2005) 309-317
23. Arikawa-Hirasawa E., Watanabe H., Takami H., Hassell J.R., and Yamada Y. Perlecan is essential for cartilage and cephalic development. Nat. Genet. 23 (1999) 354-358
24. Sørensen H.P., Vivès R.R., Manetopoulos C., Albrechtsen R., Lydolph M.C., Jacobsen J., Couchman J.R., and Wewer U.M. Heparan Sulfate Regulates ADAM12 through a molecular switch mechanism. J. Biol. Chem. 283 (2008) 31920-31932
25. Kobayashi M., Naomoto Y., Nobuhisa T., Okawa T., Takaoka M., Shirakawa Y., Yamatsuji T., Matsuoka J., Mizushima T., Matsuura H., Nakajima M., Nakagawa H., Rustgi A., and Tanaka N. Heparanase regulates esophageal keratinocyte differentiation through nuclear translocation and heparan sulfate cleavage. Differentiation 74 (2006) 235-243
26. Jin M., Ishida M., Katoh-Fukui Y., Tsuchiya R., Higashinakagawa T., Ikegami S., and Arimatsu Y. Reduced pain sensitivity in mice lacking latexin, An inhibitor of metallocarboxypeptidases. Brain Res. 1075 (2006) 117-121