A novel gene, fudoh, in the SCCmec region suppresses the colony spreading ability and virulence of Staphylococcus aureus

PLoS ONE

Volumn 3, Issue 12, 2008, Pages

  Kaito, Chikara ^a   Omae, Yosuke ^a   Matsumoto, Yasuhiko ^a   Nagata, Makiko ^a   Yamaguchi, Hiroki ^b   Aoto, Taiji ^b   Ito, Teruyo ^c   Hiramatsu, Keiichi ^c   Sekimizu, Kazuhisa ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; EXOTOXIN; FUDOH PROTEIN; PENICILLIN BINDING PROTEIN 2A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CONTROLLED STUDY; FEMALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; STAPHYLOCOCCUS AUREUS; ANIMAL; BACTERIAL COUNT; BACTERIAL GENE; BACTERIUM TRANSFORMATION; DEMOGRAPHY; GENE DELETION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PATHOGENICITY; PENICILLIN RESISTANCE; VIRULENCE;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MUS; STAPHYLOCOCCUS AUREUS;

ANIMALS; COLONY COUNT, MICROBIAL; EXOTOXINS; GENES, BACTERIAL; METHICILLIN RESISTANCE; MICE; RESIDENCE CHARACTERISTICS; SEQUENCE DELETION; STAPHYLOCOCCUS AUREUS; TRANSFORMATION, BACTERIAL; VIRULENCE;

EID: 57749209833     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003921     Document Type: Article

References (29)

1. Hiramatsu K (2001) Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistance. Lancet Infect Dis 1: 147-155.
2. Chambers HF (2005) Community-associated MRSA-resistance and virulence converge. N Engl J Med 352: 1485-1487.
3. Rozgonyi F, Kocsis E, Kristof K, Nagy K (2007) Is MRSA more virulent than MSSA? Clin Microbiol Infect 13: 843-845.
4. Mizobuchi S, Minami J, Jin F, Matsushita O, Okabe A (1994) Comparison of the virulence of methicillin-resistant and methicillin-sensitive Staphylococcus aureus. Microbiol Immunol 38: 599-605.
5. Voyich JM, Braughton KR, Sturdevant DE, Whitney AR, Said-Salim B, et al. (2005) Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils. J Immunol 175: 3907-3919.
6. Diep BA, Gill SR, Chang RF, Phan TH, Chen JH, et al. (2006) Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus. Lancet 367: 731-739.
7. Baba T, Takeuchi F, Kuroda M, Yuzawa H, Aoki K, et al. (2002) Genome and virulence determinants of high virulence community-acquired MRSA. Lancet 359: 1819-1827.
8. Labandeira-Rey M, Couzon F, Boisset S, Brown EL, Bes M, et al. (2007) Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia. Science 315: 1130-1133.
9. Voyich JM, Otto M, Mathema B, Braughton KR, Whitney AR, et al. (2006) Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J Infect Dis 194: 1761-1770.
10. Wang R, Braughton KR, Kretschmer D, Bach TH, Queck SY, et al. (2007) Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med 13: 1510-1514.
11. Kaito C, Sekimizu K (2007) Colony spreading in Staphylococcus aureus. J Bacteriol 189: 2553-2557.
12. Josenhans C, Suerbaum S (2002) The role of motility as a virulence factor in bacteria. Int J Med Microbiol 291: 605-614.
13. Krukonis ES, DiRita VJ (2003) From motility to virulence: Sensing and responding to environmental signals in Vibrio cholerae. Curr Opin Microbiol 6: 186-190.
14. Cossart P, Sansonetti PJ (2004) Bacterial invasion: the paradigms of enteroinvasive pathogens. Science 304: 242-248.
15. Kuroda M, Ohta T, Uchiyama I, Baba T, Yuzawa H, et al. (2001) Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet 357: 1225-1240.
16. Suzuki E, Kuwahara-Arai K, Richardson JF, Hiramatsu K (1993) Distribution of mec regulator genes in methicillin-resistant Staphylococcus clinical strains. Antimicrob Agents Chemother 37: 1219-1226.
17. Hiramatsu K, Cui L, Kuroda M, Ito T (2001) The emergence and evolution of methicillin-resistant Staphylococcus aureus. Trends Microbiol 9: 486-493.
18. Daum RS, Ito T, Hiramatsu K, Hussain F, Mongkolrattanothai K, et al. (2002) A novel methicillin-resistance cassette in community-acquired methicillin-resistant Staphylococcus aureus isolates of diverse genetic backgrounds. J Infect Dis 186: 1344-1347.
19. Naimi TS, LeDell KH, Boxrud DJ, Groom AV, Steward CD, et al. (2001) Epidemiology and clonality of community-acquired methicillin-resistant Staphylococcus aureus in Minnesota, 1996-1998. Clin Infect Dis 33: 990-996.
20. Hanssen AM, Sollid JU (2007) Multiple staphylococcal cassette chromosomes and allelic variants of cassette chromosome recombinases in Staphylococcus aureus and coagulase-negative staphylococci from Norway. Antimicrob Agents Chemother 51: 1671-1677.
21. Higashide M, Kuroda M, Omura CT, Kumano M, Ohkawa S, et al. (2008) Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. Antimicrob Agents Chemother 52: 2061-2068.
22. Noto MJ, Kreiswirth BN, Monk AB, Archer GL (2008) Gene acquisition at the insertion site for SCCmec, the genomic island conferring methicillin resistance in Staphylococcus aureus. J Bacteriol 190: 1276-1283.
23. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press. pp 3 v.
24. Kaito C, Kurokawa K, Matsumoto Y, Terao Y, Kawabata S, et al. (2005) Silkworm pathogenic bacteria infection model for identification of novel virulence genes. Mol Microbiol 56: 934-944.
25. Katayama Y, Ito T, Hiramatsu K (2000) A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother 44: 1549-1555.
26. Ichihashi N, Kurokawa K, Matsuo M, Kaito C, Sekimizu K (2003) Inhibitory effects of basic or neutral phospholipid on acidic phospholipid-mediated dissociation of adenine nucleotide bound to DnaA protein, the initiator of chromosomal DNA replication. J Biol Chem 278: 28778-28786.
27. Novick RP (1991) Genetic systems in staphylococci. Methods Enzymol 204: 587-636.
28. Kondo Y, Ito T, Ma XX, Watanabe S, Kreiswirth BN, et al. (2007) Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions. Antimicrob Agents Chemother 51: 264-274.
29. Kaito C, Morishita D, Matsumoto Y, Kurokawa K, Sekimizu K (2006) Novel DNA binding protein SarZ contributes to virulence in Staphylococcus aureus. Mol Microbiol 62: 1601-1617.