Liposome-encapsulated hemoglobin reduces the size of cerebral infarction in rats: Effect of oxygen affinity

Artificial Organs

Volumn 33, Issue 2, 2009, Pages 159-163

  Fukumoto, Dai ^a   Kawaguchi, Akira T ^b   Haida, Munetaka ^b   Yamano, Mariko ^c   Ogata, Yoshitaka ^d   Tsukada, Hideo ^a  

^a CENTRAL RESEARCH LABORATORY   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Osaka Prefecture University   (Japan)

^d TERUMO CORPORATION   (Japan)

Author keywords

Artificial oxygen carrier; Brain ischemia; Cerebral infarction; Experiment; Microcirculation; Oxygen affinity; Oxygen delivery; Reperfusion

Indexed keywords

BRAIN; CHLORINE COMPOUNDS; HEMOGLOBIN; MICROCIRCULATION; OXYGEN; PARTICLE SIZE;

ARTIFICIAL OXYGEN CARRIER; BRAIN ISCHEMIA; CEREBRAL INFARCTION; EFFECT OF OXYGEN; EFFECTIVE DOSE; LIPOSOME ENCAPSULATED HEMOGLOBINS; OXYGEN AFFINITY; OXYGEN DELIVERY; PROTECTIVE EFFECTS; REPERFUSION;

RATS;

HEMOGLOBIN; LIPOSOME; TRIPHENYLTETRAZOLIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASAL GANGLION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DOSE COMPARISON; DRUG EFFECT; ENCAPSULATION; ERYTHROCYTE; HISTOPATHOLOGY; MALE; MIDDLE CEREBRAL ARTERY; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; OXYGEN AFFINITY; PARTICLE SIZE; PHOTOCHEMISTRY; PRIORITY JOURNAL; RAT;

PRIMATES; RATTUS; RODENTIA;

EID: 57749201812     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/j.1525-1594.2008.00701.x     Document Type: Article

References (17)

1. Saxena R, Wijnhoud AD, Carton H, et al. Controlled safety study of a hemoglobin-based oxygen carrier, dclhb, in acute ischemic stroke. Stroke 1999 30 : 993 6.
2. LaMuraglia GM, O'Hara PJ, Baker WH, et al. The reduction of the allogeneic transfusion requirement in aortic surgery with a hemoglobin-based solution. J Vasc Surg 2000 31 : 299 308.
3. Natanson C, Kern SJ, Lurie P, Banks SM, Wolfe SM. Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death. JAMA 2008 299 : 2304 12.
4. Simoni J, Villanueva-Meyer J, Simoni G, Moeller JF, Wesson DE. Control of oxidative reactions of hemoglobin in the design of blood substitutes: role of the ascorbate-glutathione antioxidant system. Artif Organs 2009 33 : 115 26.
5. Phillips WT, Lemen L, Goins B, et al. Use of oxygen-15 to measure oxygen-carrying capacity of blood substitutes in vivo. Am J Physiol Heart Circ Physiol 1997 272 : H2492 9.
6. Sakai H, Takeoka S, Wettstein R, Tsai AG, Intaglietta M, Tsuchida E. Systemic and microvascular responses to hemorrhagic shock and resuscitation with Hb vesicles. Am J Physiol Heart Circ Physiol 2002 283 : H1191 9.
7. Ogata Y. Characteristics and function of human hemoglobin vesicles as an oxygen carrier. Polym Adv Technol 2000 11 : 205 9.
8. Awasthi V, Yee SH, Jerabek P, Goins B, Phillips WT. Cerebral oxygen delivery by liposome-encapsulated hemoglobin: a positron-emission tomographic evaluation in a rat model of hemorrhagic shock. J Appl Physiol 2007 103 : 28 38.
9. Nogami Y, Kinoshita M, Takase B, et al. Liposome encapsulated hemoglobin transfusion rescues rats undergoing progressive hemodilution from lethal organ hypoxia without scavenging nitric oxide. Ann Surg 2008 248 : 310 9.
10. Kaneda S, Ishizuka T, Goto H, Kimura T, Inaba K, Kasukawa H. Liposome-encapsulated hemoglobin, TRM-645: current status of the development and important issues for clinical application. Artif Organs 2009 33 : 146 52.
11. Kawaguchi AT, Fukumoto D, Haida M, Ogata Y, Yamano M, Tsukada H. Liposome-encapsulated hemoglobin reduces the size of cerebral infarction in the rat. Evaluation with photochemically induced thrombosis of the middle cerebral artery. Stroke 2007 38 : 1626 32.
12. 2 carrier after brain ischemia and reperfusion in the primate. Stroke 2007 38 : 599 Abstract K, Wada K, Uematsu T, Nakashima M. Evaluation of the combination of a tissue-type plasminogen activater, SUN9216, and a thromboxane A2 receptor antagonist, vapiprost, in a rat middle cerebral artery thrombosis model. Stroke 1993 24 : 1077 82.
13. Pettigrew LC, Holtz ML, Craddock SD, Minger SL, Hall N, Geddes JW. Microtubular proteolosis in focal ischemia. J Cereb Blood Flow Metab 1996 16 : 1189 202.
14. Krogh A. The supply of oxygen to the tissue and the regulation of the capillary circulation. J Physiol 1919 52 : 457 74.
15. Theilen H, Schrock H, Kuschinsky W. Gross persistence of capillary plasma perfusion after middle cerebral artery occlusion in the rat brain. J Cereb Blood Flow Metab 1994 14 : 1055 61.
16. Kawaguchi AT, Kurita D, Furuya H, Yamano M, Ogata Y, Haida M. Liposome-encapsulated hemoglobin alleviates brain edema after permanent occlusion of the middle cerebral artery in rats. Artif Organs 2009 33 : 153 8.
17. Reedy M, Labhasetwar V. Targeted delivery of SOD encapsulated nanoparticles to brain reduced ischemia/reperfusion injury. Stroke 2007 38 : 460 Abstract T, Kawaguchi AT, Akai S, et al. In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography. Artif Organs 2009 33 : 164 8.