The genetic variation in the tenomodulin gene is associated with serum total and LDL cholesterol in a body size-dependent manner

International Journal of Obesity

Volumn 32, Issue 12, 2008, Pages 1868-1872

  Tolppanen, A M ^a   Pulkkinen, L ^a   Kuulasmaa, T ^b   Kolehmainen, M ^a   Schwab, U ^a,b   Lindstrom J ^c   Tuomilehto, J ^c,d   Uusitupa, M ^a   Kuusisto, J ^b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Serum lipoproteins; Tenomodulin

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGED; ARTICLE; BODY MASS; BODY SIZE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; FINLAND; GENE; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; IMPAIRED GLUCOSE TOLERANCE; LIFESTYLE MODIFICATION; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; TNMD GENE;

ADULT; AGED; BODY MASS INDEX; BODY SIZE; CHOLESTEROL; CHOLESTEROL, LDL; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; FINLAND; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MEMBRANE PROTEINS; METABOLIC SYNDROME X; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK ASSESSMENT;

EID: 57749180639     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2008.217     Document Type: Article

References (23)

1. Tolppanen AM, Pulkkinen L, Kolehmainen M, Schwab U, Lindstrom J, Tuomilehto J et al. Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study. Obesity (Silver Spring) 2007; 15: 1082-1088.
2. Tolppanen AM, Pulkkinen L, Herder C, Koenig W, Kolehmainen M, Lindstrom J et al. The genetic variation of the tenomodulin gene (TNMD) is associated with serum levels of systemic immune mediators - the Finnish Diabetes Prevention Study. Genet Med 2008; 10: 536-544.
3. Kolehmainen M, Salopuro T, Schwab US, Kekalainen J, Kallio P, Laaksonen DE et al. Weight reduction modulates expression of genes involved in extracellular matrix and cell death: the GENOBIN study. Int J Obes (Lond) 2008; 32: 292-303.
4. Sanchez-Pulido L, Devos D, Valencia A. BRICHOS: a conserved domain in proteins associated with dementia, respiratory distress and cancer. Trends Biochem Sci 2002; 27: 329-332.
5. Shukunami C, Oshima Y, Hiraki Y. Molecular cloning of tenomodulin, a novel chondromodulin-I related gene. Biochem Biophys Res Commun 2001; 280: 1323-1327.
6. Docheva D, Hunziker EB, Fassler R, Brandau O. Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Mol Cell Biol 2005; 25: 699-705.
7. Oshima Y, Sato K, Tashiro F, Miyazaki J, Nishida K, Hiraki Y et al. Anti-angiogenic action of the C-terminal domain of tenomodulin that shares homology with chondromodulin-I. J Cell Sci 2004; 117: 2731-2744.
8. Dahlman I, Linder K, Arvidsson Nordstrom E, Andersson I, Liden J, Verdich C et al. Changes in adipose tissue gene expression with energy-restricted diets in obese women. Am J Clin Nutr 2005; 81: 1275-1285.
9. Wang J, Kuusisto J, Vanttinen M, Kuulasmaa T, Lindstrom J, Tuomilehto J et al. Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion. Diabetologia 2007; 50: 1192-1200.
10. World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Part 1 Diagnosis and Classification of Diabetes Mellitus 1999. World Health Organization, Department of Noncommunicable Disease Surveillance, Geneva, 1999.
11. Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001; 344: 1343-1350.
12. Eriksson J, Lindström J, Valle T, Aunola S, Hämälä inen H, Ilanne-Parikka P et al. Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme. Diabetologia 1999; 42: 793-801.
13. Ashley Jr FW, Kannel WB. Relation of weight change to changes in atherogenic traits: the Framingham Study. J Chronic Dis 1974; 27: 103-114.
14. Kesaniemi YA, Beltz WF, Grundy SM. Comparisons of metabolism of apolipoprotein B in normal subjects, obese patients, and patients with coronary heart disease. J Clin Invest 1985; 76: 586-595.
15. Grundy SM, Denke MA. Dietary influences on serum lipids and lipoproteins. J Lipid Res 1990; 31: 1149-1172.
16. Miettinen TA. Cholesterol production in obesity. Circulation 1971; 44: 842-850.
17. Manley PN, Ancsin JB, Kisilevsky R. Rapid recycling of cholesterol: the joint biologic role of C-reactive protein and serum amyloid A. Med Hypotheses 2006; 66: 784-792.
18. Su AI, Cooke MP, Ching KA, Hakak Y, Walker JR, Wiltshire T et al. Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci USA 2002; 99: 4465-4470.
19. Carrel L, Willard HF. X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 2005; 434: 400-404.
20. Rinn JL, Snyder M. Sexual dimorphism in mammalian gene expression. Trends Genet 2005; 21: 298-305.
21. Van PL, Bakalov VK, Bondy CA. Monosomy for the X-chromosome is associated with an atherogenic lipid profile. J Clin Endocrinol Metab 2006; 91: 2867-2870.
22. Nikkila M, Pitkajarvi T, Koivula T, Solakivi T, Lehtimaki T, Laippala P et al. Women have a larger and less atherogenic low density lipoprotein particle size than men. Atherosclerosis 1996; 119: 181-190.
23. Van PL, Bakalov VK, Zinn AR, Bondy CA.Maternal X chromosome, visceral adiposity, and lipid profile. JAMA 2006; 295: 1373-1374.