Sleep-Disordered Breathing: Autonomic Mechanisms and Arrhythmias

Progress in Cardiovascular Diseases

Volumn 51, Issue 4, 2009, Pages 324-338

  Leung, Richard S T ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; CARBON DIOXIDE;

AROUSAL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BRADYCARDIA; BRAIN STEM; CARDIOVASCULAR SYSTEM; CENTRAL SLEEP APNEA SYNDROME; CHEMORECEPTOR REFLEX; CLINICAL TRIAL; HEART ARRHYTHMIA; HEART BLOCK; HEART FAILURE; HEART MUSCLE EXCITABILITY; HEART SUPRAVENTRICULAR ARRHYTHMIA; HEART VENTRICLE ARRHYTHMIA; HERING BREUER REFLEX; HUMAN; POSITIVE END EXPIRATORY PRESSURE; PRESSORECEPTOR REFLEX; REM SLEEP; SLEEP APNEA SYNDROME; SUDDEN DEATH; SYMPATHETIC NERVE; TRACHEOSTOMY; VAGUS NERVE STIMULATION;

AROUSAL; ARRHYTHMIAS, CARDIAC; AUTONOMIC NERVOUS SYSTEM; CONTINUOUS POSITIVE AIRWAY PRESSURE; EVIDENCE-BASED MEDICINE; HUMANS; SLEEP APNEA SYNDROMES; SLEEP APNEA, CENTRAL; SLEEP APNEA, OBSTRUCTIVE; TREATMENT OUTCOME; VENTRICULAR FIBRILLATION;

EID: 57749117456     PISSN: 00330620     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pcad.2008.06.002     Document Type: Article

References (138)

1. Young T., Palta M., Dempsey J., et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328 (1993) 1230-1235
2. Leung R.S., and Bradley T.D. Sleep apnea and cardiovascular disease. Am J Respir Crit Care Med 164 (2001) 2147-2165
3. Shahar E., Whitney C.W., Redline S., et al. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med 163 (2001) 19-25
4. Peppard P.E., Young T., Palta M., et al. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342 (2000) 1378-1384
5. Arzt M., Young T., Finn L., et al. Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med 172 (2005) 1447-1451
6. Marin J.M., Carrizo S.J., Vicente E., et al. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 365 (2005) 1046-1053
7. Javaheri S., Parker T.J., Liming J.D., et al. Sleep apnea in 81 ambulatory male patients with stable heart failure. Types and their prevalences, consequences, and presentations. Circulation 97 (1998) 2154-2159 [see comments]
8. Sin D.D., Fitzgerald F., Parker J.D., et al. Risk factors for central and obstructive sleep apnea in 450 men and women with congestive heart failure. Am J Respir Crit Care Med 160 (1999) 1101-1106 [see comments]
9. Guilleminault C., Connolly S.J., and Winkle R.A. Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol 52 (1983) 490-494
10. Mehra R., Benjamin E.J., Shahar E., et al. Association of nocturnal arrhythmias with sleep-disordered breathing: the Sleep Heart Health Study. Am J Respir Crit Care Med 173 (2006) 910-916
11. Javaheri S., and Corbett W.S. Association of low Paco2 with central sleep apnea and ventricular arrhythmias in ambulatory patients with stable heart failure. Ann Intern Med 128 (1998) 204-207
12. Naughton M.T., Benard D.C., Liu P.P., et al. Effects of nasal CPAP on sympathetic activity in patients with heart failure and central sleep apnea. Am J Respir Crit Care Med 152 (1995) 473-479
13. Trinder J., Merson R., Rosenberg J.I., et al. Pathophysiological interactions of ventilation, arousals, and blood pressure oscillations during Cheyne-Stokes respiration in patients with heart failure. Am J Respir Crit Care Med 162 3 Pt. 1 (2000) 808-813
14. McGinty D., and Szymusiak R. Neurobiology of sleep. In: Saunders N.A., and Sullivan C.E. (Eds). Sleep and breathing. 2nd ed. vol. 71 (1994), Marcel Dekker, New York 1-26
15. Phillipson E.A., and Bowes G. Control of breathing during sleep. In: Cherniack N.S., and Widdicombe J.G. (Eds). Handbook of physiology: Vol. 2, Control of breathing (1986), Williams and Wilkins, Bethesda (Md) 649-689
16. Phillipson E.A. Control of breathing during sleep. Am Rev Respir Dis 118 (1978) 909-939
17. White D.P., Weil J.V., and Zwillich C.W. Metabolic rate and breathing during sleep. J Appl Physiol 59 (1985) 384-391
18. Somers V.K., Dyken M.E., Mark A.L., et al. Sympathetic-nerve activity during sleep in normal subjects. N Engl J Med 328 (1993) 303-307
19. Shepard Jr. J.W. Gas exchange and hemodynamics during sleep. Med Clin North Am 69 (1985) 1243-1264
20. Hornyak M., Cejnar M., Elam M., et al. Sympathetic muscle nerve activity during sleep in man. Brain 114 Pt. 3 (1991) 1281-1295
21. Okada H., Iwase S., Mano T., et al. Changes in muscle sympathetic nerve activity during sleep in humans. Neurology 41 (1991) 1961-1966
22. Mancia G. Autonomic modulation of the cardiovascular system during sleep. N Engl J Med 328 (1993) 347-349
23. Kong Jr. T.Q., Goldberger J.J., Parker M., et al. Circadian variation in human ventricular refractoriness. Circulation 92 (1995) 1507-1516
24. Lown B., Tykocinski M., Garfein A., et al. Sleep and ventricular premature beats. Circulation 48 (1973) 691-701
25. Pitzalis M.V., Mastropasqua F., Massari F., et al. Sleep suppression of ventricular arrhythmias: a predictor of beta-blocker efficacy. Eur Heart J 17 (1996) 917-925
26. Horner R.L., Brooks D., Kozar L.F., et al. Immediate effects of arousal from sleep on cardiac autonomic outflow in the absence of breathing in dogs. J Appl Physiol 79 (1995) 151-162
27. 2 levels between sleep and wakefulness. J Physiol 534 Pt. 3 (2001) 881-890
28. Willich S.N., Goldberg R.J., Maclure M., et al. Increased onset of sudden cardiac death in the first three hours after awakening. Am J Cardiol 70 (1992) 65-68
29. Tofler G.H., Gebara O.C., Mittleman M.A., et al. Morning peak in ventricular tachyarrhythmias detected by time of implantable cardioverter/defibrillator therapy. The CPI Investigators. Circulation 92 (1995) 1203-1208
30. Orem J. Neuronal mechanisms of respiration in REM sleep. Sleep 3 (1980) 251-267
31. Chandler S.H., Chase M.H., and Nakamura Y. Intracellular analysis of synaptic mechanisms controlling trigeminal motoneuron activity during sleep and wakefulness. J Neurophysiol 44 (1980) 359-371
32. Snyder F., Hobson J.A., Morrison D.F., et al. Changes in respiration, heart rate, and systolic blood pressure in human sleep. J Appl Physiol 19 (1964) 417-422
33. Somers V.K., Dyken M.E., Clary M.P., et al. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96 (1995) 1897-1904
34. Hedner J., Ejnell H., Sellgren J., et al. Is high and fluctuating muscle nerve sympathetic activity in the sleep apnoea syndrome of pathogenetic importance for the development of hypertension. J Hypertens Suppl 6 (1988) S529-S531
35. Leuenberger U., Jacob E., Sweer L., et al. Surges of muscle sympathetic nerve activity during obstructive apnea are linked to hypoxemia. J Appl Physiol 79 (1995) 581-588
36. Tilkian A.G., Guilleminault C., Schroeder J.S., et al. Hemodynamics in sleep-induced apnea. Studies during wakefulness and sleep. Ann Intern Med 85 (1976) 714-719
37. Ringler J., Basner R.C., Shannon R., et al. Hypoxemia alone does not explain blood pressure elevations after obstructive apneas. J Appl Physiol 69 (1990) 2143-2148
38. Portaluppi F., Provini F., Cortelli P., et al. Undiagnosed sleep-disordered breathing among male nondippers with essential hypertension. J Hypertens 15 (1997) 1227-1233
39. Carlson J.T., Hedner J., Elam M., et al. Augmented resting sympathetic activity in awake patients with obstructive sleep apnea. Chest 103 (1993) 1763-1768
40. Narkiewicz K., Montano N., Cogliati C., et al. Altered cardiovascular variability in obstructive sleep apnea. Circulation 98 (1998) 1071-1077
41. Fletcher E.C., Miller J., Schaaf J.W., et al. Urinary catecholamines before and after tracheostomy in patients with obstructive sleep apnea and hypertension. Sleep 10 (1987) 35-44
42. Hedner J., Darpo B., Ejnell H., et al. Reduction in sympathetic activity after long-term CPAP treatment in sleep apnoea: cardiovascular implications. Eur Respir J 8 (1995) 222-229
43. Narkiewicz K., Kato M., Phillips B.G., et al. Nocturnal continuous positive airway pressure decreases daytime sympathetic traffic in obstructive sleep apnea. Circulation 100 (1999) 2332-2335
44. Waradekar N.V., Sinoway L.I., Zwillich C.W., et al. Influence of treatment on muscle sympathetic nerve activity in sleep apnea. Am J Respir Crit Care Med 153 4 Pt. 1 (1996) 1333-1338
45. Kleiger R.E., Miller J.P., Bigger Jr. J.T., et al. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 59 (1987) 256-262
46. Ponikowski P., Anker S.D., Chua T.P., et al. Depressed heart rate variability as an independent predictor of death in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 79 (1997) 1645-1650
47. Task: heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93 (1996) 1043-1065
48. Noda A., Yasuma F., Okada T., et al. Circadian rhythm of autonomic activity in patients with obstructive sleep apnea syndrome. Clin Cardiol 21 (1998) 271-276
49. Wiklund U., Olofsson B.O., Franklin K., et al. Autonomic cardiovascular regulation in patients with obstructive sleep apnoea: a study based on spectral analysis of heart rate variability. Clin Physiol 20 (2000) 234-241
50. Shiomi T., Guilleminault C., Sasanabe R., et al. Augmented very low frequency component of heart rate variability during obstructive sleep apnea. Sleep 19 (1996) 370-377
51. Mortara A., Sleight P., Pinna G.D., et al. Abnormal awake respiratory patterns are common in chronic heart failure and may prevent evaluation of autonomic tone by measures of heart rate variability. Circulation 96 (1997) 246-252
52. Hirsch J.A., and Bishop B. Respiratory sinus arrhythmia in humans: how breathing pattern modulates heart rate. Am J Physiol 241 (1981) H620-H629
53. Brown T.E., Beightol L.A., Koh J., et al. Important influence of respiration on human R-R interval power spectra is largely ignored. J Appl Physiol 75 (1993) 2310-2317
54. Novak V., Saul J.P., and Eckberg D.L. Task Force report on heart rate variability. Circulation 96 (1997) 1056-1057
55. Khoo M.C., Kim T.S., and Berry R.B. Spectral indices of cardiac autonomic function in obstructive sleep apnea. Sleep 22 (1999) 443-451
56. Roche F., Court-Fortune I., Pichot V., et al. Reduced cardiac sympathetic autonomic tone after long-term nasal continuous positive airway pressure in obstructive sleep apnoea syndrome. Clin Physiol 19 (1999) 127-134
57. Spaak J., Egri Z.J., Kubo T., et al. Muscle sympathetic nerve activity during wakefulness in heart failure patients with and without sleep apnea. Hypertension 46 (2005) 1327-1332
58. Bradley T.D., Tkacova R., Hall M.J., et al. Augmented sympathetic neural response to simulated obstructive apnoea in human heart failure. Clin Sci (Lond) 104 (2003) 231-238
59. Usui K., Bradley T.D., Spaak J., et al. Inhibition of awake sympathetic nerve activity of heart failure patients with obstructive sleep apnea by nocturnal continuous positive airway pressure. J Am Coll Cardiol 45 (2005) 2008-2011
60. Mansfield D.R., Gollogly N.C., Kaye D.M., et al. Controlled trial of continuous positive airway pressure in obstructive sleep apnea and heart failure. Am J Respir Crit Care Med 169 (2004) 361-366
61. Mansfield D., Kaye D.M., Brunner La Rocca H., et al. Raised sympathetic nerve activity in heart failure and central sleep apnea is due to heart failure severity. Circulation 107 (2003) 1396-1400
62. Saul J.P., Arai Y., Berger R.D., et al. Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis. Am J Cardiol 61 (1988) 1292-1299
63. Tateishi O., Shouda T., Sakai T., et al. Apnea-related heart rate variability in congestive heart failure patients. Clin Exp Hypertens 25 (2003) 183-189
64. Lanfranchi P.A., Braghiroli A., Bosimini E., et al. Prognostic value of nocturnal Cheyne-Stokes respiration in chronic heart failure. Circulation 99 (1999) 1435-1440
65. Lanfranchi P.A., Somers V.K., Braghiroli A., et al. Central sleep apnea in left ventricular dysfunction: prevalence and implications for arrhythmic risk. Circulation 107 (2003) 727-732
66. Gilman M.P., Floras J.S., Usui K., et al. Continuous positive airway pressure increases heart rate variability in heart failure patients with obstructive sleep apnoea. Clin Sci (Lond) 114 (2008) 243-249
67. Anrep G.V., Pascual W., and Rossler R. Respiratory variations of the heart rate I. The reflex mechanism of the respiratory sinus arrhythmia. Proc R Soc Lond Biol Sci 119B (1936) 191-217
68. Eckberg D.L., Nerhed C., and Wallin B.G. Respiratory modulation of muscle sympathetic and vagal cardiac outflow in man. J Physiol 365 (1985) 181-196
69. Eckberg D.L. Temporal response patterns of the human sinus node to brief carotid baroreceptor stimuli. J Physiol 258 (1976) 769-782
70. Eckberg D.L., and Eckberg M.J. Human sinus node responses to repetitive, ramped carotid baroreceptor stimuli. Am J Physiol 242 (1982) H638-H644
71. Wallin B.G., and Nerhed C. Relationship between spontaneous variations of muscle sympathetic activity and succeeding changes of blood pressure in man. J Auton Nerv Syst 6 (1982) 293-302
72. Guilleminault C., Connolly S., Winkle R., et al. Cyclical variation of the heart rate in sleep apnoea syndrome. Mechanisms, and usefulness of 24 h electrocardiography as a screening technique. Lancet 1 (1984) 126-131
73. Leung R.S., Floras J.S., Lorenzi-Filho G., et al. Influence of Cheyne-Stokes respiration on cardiovascular oscillations in heart failure. Am J Respir Crit Care Med 167 (2003) 1534-1539
74. Shykoff B.E., Naqvi S.S., Menon A.S., et al. Respiratory sinus arrhythmia in dogs. Effects of phasic afferents and chemostimulation. J Clin Invest 87 (1991) 1621-1627
75. Anrep G.V., Pascual W., and Rossler R. Respiratory variations of the heart rate II. The central mechanism of the respiratory arrhythmia and the interrelations between the central and reflex mechanisms. Proc R Soc Lond Biol Sci 119B (1936) 218-230
76. Gooden B.A. Mechanism of the human diving response. Integr Physiol Behav Sci 29 (1994) 6-16
77. Haselton J.R., and Guyenet P.G. Central respiratory modulation of medullary sympathoexcitatory neurons in rat. Am J Physiol 256 3 Pt. 2 (1989) R739-R750
78. Guyenet P.G. Lower brainstem mechanisms of respiratory integration. In: Bradley T.D., and Floras J.S. (Eds). Sleep apnea: implications in cardiovascular and cerebrovascular disease vol. 146 (2000), Marcel Dekker, New York 61-98
79. Seals D.R., Suwarno N.O., Joyner M.J., et al. Respiratory modulation of muscle sympathetic nerve activity in intact and lung denervated humans. Circ Res 72 (1993) 440-454
80. Leung R.S., Lorenzi-Filho G., Floras J.S., et al. Entrainment of blood pressure and heart rate by Cheyne-Stokes respiration in patients with congestive heart failure. Am J Respir Crit Care Med 161 (2000) A865
81. Gerber U., and Polosa C. Effects of pulmonary stretch receptor afferent stimulation on sympathetic preganglionic neuron firing. Can J Physiol Pharmacol 56 (1978) 191-198
82. Daly M.d.B., and Robinson B.H. An analysis of the reflex systemic vasodilator response elicited by lung inflation in the dog. J Physiol 195 (1968) 387-406
83. Somers V.K., Mark A.L., Zavala D.C., et al. Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol 67 (1989) 2101-2106
84. Bainbridge F.A. The relationship between respiration and the pulse-rate. J Physiol 54 (1920) 192-202
85. Bergstrom R.M., Hakumaki M.O., and Sarajas H.S. Heart rate in relation to sympathetic efferentation associated with the Bainbridge reflex in dogs. Acta Physiol Scand 83 (1971) 571-573
86. Hakumaki M.O. Seventy years of the Bainbridge reflex. Acta Physiol Scand 130 (1987) 177-185
87. Barbieri R., Triedman J.K., and Saul J.P. Heart rate control and mechanical cardiopulmonary coupling to assess central volume: a systems analysis. Am J Physiol Regul Integr Comp Physiol 283 (2002) R1210-R1220
88. Pagani M., Schwartz P.J., Banks R., et al. Reflex responses of sympathetic preganglionic neurons initiated by different cardiovascular receptors in spinal animals. Brain Res 68 (1974) 215-225
89. Gupta P.D. Spinal autonomic afferents in elicitation of tachycardia in volume infusion in the dog. Am J Physiol 229 (1975) 303-308
90. Abboud F.M., Eckberg D.L., Johannsen U.J., et al. Carotid and cardiopulmonary baroreceptor control of splanchnic and forearm vascular resistance during venous pooling in man. J Physiol 286 (1979) 173-184
91. Sundlof G., and Wallin B.G. Effect of lower body negative pressure on human muscle nerve sympathetic activity. J Physiol 278 (1978) 525-532
92. Doyle J.T., Wilson J.S., Estes E.H., et al. The effect of intravenous infusions of physiological saline solution on the pulmonary arterial and pulmonary capillary pressure in man. J Clin Invest 30 (1951) 345-352
93. Takeshita A., Mark A.L., Eckberg D.L., et al. Effect of central venous pressure on arterial baroreflex control of heart rate. Am J Physiol 236 (1979) H42-H47
94. Middlekauff H.R., Nitzsche E.U., Hamilton M.A., et al. Evidence for preserved cardiopulmonary baroreflex control of renal cortical blood flow in humans with advanced heart failure. A positron emission tomography study. Circulation 92 (1995) 395-401
95. Floras J.S. Sympathetic activation in human heart failure: diverse mechanisms, therapeutic opportunities. Acta Physiol Scand 177 (2003) 391-398
96. Eckberg D.L., Rea R.F., Andersson O.K., et al. Baroreflex modulation of sympathetic activity and sympathetic neurotransmitters in humans. Acta Physiol Scand 133 (1988) 221-231
97. Carlson J.T., Hedner J.A., Sellgren J., et al. Depressed baroreflex sensitivity in patients with obstructive sleep apnea. Am J Respir Crit Care Med 154 (1996) 1490-1496
98. van de Borne P., Oren R., Abouassaly C., et al. Effect of Cheyne-Stokes respiration on muscle sympathetic nerve activity in severe congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 81 (1998) 432-436
99. Lugliani R., Whipp B.J., and Wasserman K. A role for the carotid body in cardiovascular control in man. Chest 63 (1973) 744-750
100. Bernthal T., Green Jr. W., and Revzin A.M. Role of the carotid body chemoreceptors in hypoxic cardiac acceleration. Proc Soc Exp Biol Med 143 (1951) 361-372
101. Daly M.d.B., and Scott M.J. The cardiovascular responses to stimulation of the carotid chemoreceptors in the dog. J Physiol 165 (1963) 179-197
102. Daly M.d.B., and Scott M.J. The effects of stimulation of the carotid body chemoreceptors on heart rate in the dog. J Physiol 144 (1958) 148-166
103. Ponikowski P., Anker S.D., Chua T.P., et al. Oscillatory breathing patterns during wakefulness in patients with chronic heart failure: clinical implications and role of augmented peripheral chemosensitivity. Circulation 100 (1999) 2418-2424
104. Solin P., Roebuck T., Johns D.P., et al. Peripheral and central ventilatory responses in central sleep apnea with and without congestive heart failure. Am J Respir Crit Care Med 162 (2000) 2194-2200
105. Richardson D.W., Wasserman A.J., and Patterson Jr. J.L. General and regional circulatory responses to change in blood pH and carbon dioxide tension. J Clin Invest 40 (1961) 31-43
106. Wilcox I., McNamara S.G., Dodd M.J., et al. Ventilatory control in patients with sleep apnoea and left ventricular dysfunction: comparison of obstructive and central sleep apnoea. Eur Respir J 11 (1998) 7-13 [see comments]
107. Javaheri S. A mechanism of central sleep apnea in patients with heart failure. N Engl J Med 341 (1999) 949-954 [see comments]
108. Narkiewicz K., Pesek C.A., van de Borne P.J., et al. Enhanced sympathetic and ventilatory responses to central chemoreflex activation in heart failure. Circulation 100 (1999) 262-267
109. Hoffstein V., and Mateika S. Cardiac arrhythmias, snoring, and sleep apnea. Chest 106 (1994) 466-471
110. Miller W.P. Cardiac arrhythmias and conduction disturbances in the sleep apnea syndrome. Prevalence and significance. Am J Med 73 (1982) 317-321
111. Flemons W.W., Remmers J.E., and Gillis A.M. Sleep apnea and cardiac arrhythmias. Is there a relationship. Am Rev Respir Dis 148 (1993) 618-621
112. Laaban J.P., Cassuto D., Orvoen-Frija E., et al. Cardiorespiratory consequences of sleep apnoea syndrome in patients with massive obesity. Eur Respir J 11 (1998) 20-27
113. Koehler U., and Schafer H. Is obstructive sleep apnea (OSA) a risk factor for myocardial infarction and cardiac arrhythmias in patients with coronary heart disease (CHD)?. Sleep 19 (1996) 283-286
114. Tilkian A.G., Guilleminault C., Schroeder J.S., et al. Sleep-induced apnea syndrome. Prevalence of cardiac arrhythmias and their reversal after tracheostomy. Am J Med 63 (1977) 348-358
115. Becker H., Brandenburg U., Peter J.H., et al. Reversal of sinus arrest and atrioventricular conduction block in patients with sleep apnea during nasal continuous positive airway pressure. Am J Respir Crit Care Med 151 (1995) 215-218
116. Koehler U., Becker H.F., Grimm W., et al. Relations among hypoxemia, sleep stage, and bradyarrhythmia during obstructive sleep apnea. Am Heart J 139 1 Pt. 1 (2000) 142-148
117. Douglas N.J., White D.P., Weil J.V., et al. Hypoxic ventilatory response decreases during sleep in normal men. Am Rev Respir Dis 125 (1982) 286-289
118. Sato F., Nishimura M., Shinano H., et al. Heart rate during obstructive sleep apnea depends on individual hypoxic chemosensitivity of the carotid body. Circulation 96 (1997) 274-281
119. Bonsignore M.R., Romano S., Marrone O., et al. Different heart rate patterns in obstructive apneas during NREM sleep. Sleep 20 (1997) 1167-1174
120. Roche F., Xuong A.N., Court-Fortune I., et al. Relationship among the severity of sleep apnea syndrome, cardiac arrhythmias, and autonomic imbalance. Pacing Clin Electrophysiol 26 (2003) 669-677
121. Zwillich C., Devlin T., White D., et al. Bradycardia during sleep apnea. Characteristics and mechanism. J Clin Invest 69 (1982) 1286-1292
122. Grimm W., Hoffmann J., Menz V., et al. Electrophysiologic evaluation of sinus node function and atrioventricular conduction in patients with prolonged ventricular asystole during obstructive sleep apnea. Am J Cardiol 77 (1996) 1310-1314
123. Hinkle L.E., Carver S.T., and Stevens M. The frequency of asymptomatic disturbances of cardiac rhythm and conduction in middle-aged men. Am J Cardiol 24 (1969)
124. Canada W.B., Woodward W., Lee G., et al. Circadian rhythm of hourly ventricular arrhythmia frequency in man. Angiology 34 (1983) 274-282
125. Shepard Jr. J.W., Garrison M.W., Grither D.A., et al. Relationship of ventricular ectopy to oxyhemoglobin desaturation in patients with obstructive sleep apnea. Chest 88 (1985) 335-340
126. Franklin K.A., Nilsson J.B., Sahlin C., et al. Sleep apnoea and nocturnal angina. Lancet 345 (1995) 1085-1087
127. Alonso-Fernandez A., Garcia-Rio F., Racionero M.A., et al. Cardiac rhythm disturbances and ST-segment depression episodes in patients with obstructive sleep apnea-hypopnea syndrome and its mechanisms. Chest 127 (2005) 15-22
128. Gami A.S., Howard D.E., Olson E.J., et al. Day-night pattern of sudden death in obstructive sleep apnea. N Engl J Med 352 (2005) 1206-1214
129. Cleland J.G., Chattopadhyay S., Khand A., et al. Prevalence and incidence of arrhythmias and sudden death in heart failure. Heart Fail Rev 7 (2002) 229-242
130. Javaheri S. Effects of continuous positive airway pressure on sleep apnea and ventricular irritability in patients with heart failure. Circulation 101 (2000) 392-397
131. Leung R.S., Diep T.M., Bowman M.E., et al. Provocation of ventricular ectopy by Cheyne-Stokes respiration in patients with heart failure. Sleep 27 (2004) 1337-1343
132. Findley L.J., Blackburn M.R., Goldberger A.L., et al. Apneas and oscillation of cardiac ectopy in Cheyne-Stokes breathing during sleep. Am Rev Respir Dis 130 (1984) 937-939
133. Ryan C.M., Juvet S., Leung R., et al. Timing of nocturnal ventricular ectopy in heart failure patients with sleep apnea. Chest 133 (2008) 934-940
134. Franz M.R. Mechano-electrical feedback in ventricular myocardium. Cardiovasc Res 32 (1996) 15-24
135. Harbison J., O'Reilly P., and McNicholas W.T. Cardiac rhythm disturbances in the obstructive sleep apnea syndrome: effects of nasal continuous positive airway pressure therapy. Chest 118 (2000) 591-595
136. Ryan C.M., Usui K., Floras J.S., et al. Effect of continuous positive airway pressure on ventricular ectopy in heart failure patients with obstructive sleep apnoea. Thorax 60 (2005) 781-785
137. Bradley T.D., Logan A.G., Kimoff R.J., et al. Continuous positive airway pressure for central sleep apnea and heart failure. N Engl J Med 353 (2005) 2025-2033
138. Arzt M., Floras J.S., Logan A.G., et al. Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: a post hoc analysis of the Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure Trial (CANPAP). Circulation 115 (2007) 3173-3180