Extension of the SAEM algorithm for nonlinear mixed models with 2 levels of random effects

Biostatistics

Volumn 10, Issue 1, 2009, Pages 121-135

  Panhard, Xavire ^a   Samson, Adeline ^b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Bioequivalence trials; Crossover trial; Multilevel nonlinear mixed effects models; Multiple periods; SAEM algorithm

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ATAZANAVIR; OLIGOPEPTIDE; PYRIDINE DERIVATIVE; THEOPHYLLINE;

ALGORITHM; AREA UNDER THE CURVE; ARTICLE; BIOMETRY; CLUSTER ANALYSIS; CROSSOVER PROCEDURE; DRUG INTERACTION; EPIDEMIOLOGY; HUMAN; METHODOLOGY; MONTE CARLO METHOD; NONLINEAR SYSTEM; PHARMACOKINETICS; PROBABILITY; REGRESSION ANALYSIS; STATISTICAL MODEL; TIME;

ALGORITHMS; ANTI-HIV AGENTS; AREA UNDER CURVE; BIAS (EPIDEMIOLOGY); BIOMETRY; CLUSTER ANALYSIS; CROSS-OVER STUDIES; DRUG INTERACTIONS; HUMANS; LIKELIHOOD FUNCTIONS; MARKOV CHAINS; MONTE CARLO METHOD; NONLINEAR DYNAMICS; OLIGOPEPTIDES; PYRIDINES; REGRESSION ANALYSIS; THEOPHYLLINE; THERAPEUTIC EQUIVALENCY; TIME FACTORS;

EID: 57749092099     PISSN: 14654644     EISSN: 14684357     Source Type: Journal    
DOI: 10.1093/biostatistics/kxn020     Document Type: Article

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