Selective targeting of leukemic cell growth in vivo and in vitro using a gene silencing approach to diminish S-adenosylmethionine synthesis

Journal of Biological Chemistry

Volumn 283, Issue 45, 2008, Pages 30788-30795

  Attia, Ramy R ^a,b   Gardner, Lidia A ^a,b   Mahrous, Engy ^a   Taxman, Debra J ^c   LeGros, Leighton ^b   Rowe, Sarah ^b   Ting, Jenny P Y ^c   Geller, Arthur ^a,d   Kotb, Malak ^a,b,d  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABLATION; CELL DEATH; CELLS; CYTOLOGY; ENZYME ACTIVITY; ENZYMES; GENETIC ENGINEERING; GROWTH (MATERIALS); GROWTH KINETICS; NUCLEIC ACIDS; RNA;

ADENOSYLTRANSFERASE; APOPTOSIS; CELLS LACKING; ENGRAFTMENT; GENE SILENCING TECHNOLOGIES; IN VITRO; IN-VIVO; JURKAT CELLS; LEUKEMIC CELLS; MALIGNANT CELLS; MOUSE MODELS; PHYSIOLOGIC CONDITIONS; PHYSIOLOGIC LEVELS; RNA INTERFERENCES;

CELL GROWTH;

ADENOSINE TRIPHOSPHATE; INTERLEUKIN 2 RECEPTOR GAMMA; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; PROTEIN SUBUNIT; S ADENOSYLMETHIONINE; SHORT HAIRPIN RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER GROWTH; CATALYSIS; CATHETER ABLATION; CELL METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; DISEASE MODEL; ENGRAFTMENT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL; LEUKEMIA CELL LINE; LYMPHOCYTE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; NULL ALLELE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RNA INTERFERENCE; SCID MOUSE;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CELL SURVIVAL; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; JURKAT CELLS; LEUKEMIA; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASM TRANSPLANTATION; RNA INTERFERENCE; S-ADENOSYLMETHIONINE;

EID: 57649233173     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804159200     Document Type: Article

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