Clinical association of serum CD137 (4-1BB) levels in patients with systemic sclerosis

Journal of Dermatological Science

Volumn 53, Issue 2, 2009, Pages 159-161

  Hamaguchi, Yasuhito ^a   Hasegawa, Minoru ^a   Matsushita, Takashi ^a   Komura, Kazuhiro ^a   Takehara, Kazuhiko ^a   Fujimoto, Manabu ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

Author keywords

CD137 (4 1BB); Leukocytes; Systemic sclerosis

Indexed keywords

CD137 ANTIGEN;

ADOLESCENT; ADULT; AGED; BLOOD LEVEL; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SYSTEMIC SCLEROSIS;

ADULT; ANTIGENS, CD137; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; PROGNOSIS; PULMONARY FIBROSIS; SCLERODERMA, SYSTEMIC; UP-REGULATION;

EID: 57649214084     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2008.08.014     Document Type: Letter

References (10)

1. Hasegawa M., Sato S., Echigo T., Hamaguchi Y., Yasui M., and Takehara K. Up regulated expression of fractalkine/cx3cl1 and cx3cr1 in patients with systemic sclerosis. Ann Rheum Dis 64 (2005) 21-28
2. Watts T.H. TNF/TNFR family members in costimulation of T cell responses. Annu Rev of Immunol 23 (2005) 23-68
3. Michel J., Langstein J., Hofstadter F., and Schwarz H. A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis. Eur J Immunol 28 2 (1998) 90-95
4. Sharief M.K. Heightened intrathecal release of soluble CD137 in patients with multiple sclerosis. Eur J Neurol 9 (2002) 49-54
5. Jung H.W., Choi S.W., Choi J.I., and Kwon B.S. Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis. Exp Mol Med 36 (2004) 13-22
6. Christopeit M., Schendel M., Foll J., Muller L.P., Keysser G., and Behre G. Marked improvement of severe progressive systemic sclerosis after transplantation of mesenchymal stem cells from an allogeneic haploidentical-related donor mediated by ligation of cd137l. Leukemia 22 (2008) 1062-1064
7. Hamaguchi Y., Hasegawa M., Fujimoto M., et al. The clinical relevance of serum antinuclear antibodies in Japanese patients with systemic sclerosis. Br J Dermatol 158 (2008) 487-495
8. Olofsson P.S., Soderstrom L.A., Wagsater D., et al. CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice. Circulation 117 (2008) 1292-1301
9. Drenkard D., Becke F.M., Langstein J., et al. CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity. FASEB J 21 (2007) 456-463
10. Heinisch I.V., Daigle I., Knopfli B., and Simon H.U. CD137 activation abrogates granulocyte-macrophage colony-stimulating factor-mediated anti-apoptosis in neutrophils. Eur J Immunol 30 (2000) 3441-3446