Acupuncture protected cerebral multi-infarction rats from memory impairment by regulating the expression of apoptosis related genes Bcl-2 and Bax in hippocampus

Physiology and Behavior

Volumn 96, Issue 1, 2009, Pages 155-161

  Wang, Tong ^a,b   Liu, Cun Zhi ^a   Yu, Jian Chun ^a   Jiang, Wen ^b   Han, Jing Xian ^a  

^a FIRST TEACHING HOSPITAL OF TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Acupuncture; Apoptosis; Bax; Bcl 2; Cerebral multi infarction; Hippocampus; Morris water maze (MWM)

Indexed keywords

DNA NUCLEOTIDYLEXOTRANSFERASE; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2;

ACUPUNCTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION; CELL COUNT; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MAZE TEST; MEMORY DISORDER; NEUROPROTECTION; NICK END LABELING; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RAT; SWIMMING;

ACUPUNCTURE; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BEHAVIOR, ANIMAL; CEREBRAL INFARCTION; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; IN SITU NICK-END LABELING; MALE; MAZE LEARNING; MEMORY DISORDERS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 57649210670     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2008.09.024     Document Type: Article

References (44)

1. Stewart J.T. Psychiatric and behavioral manifestations of vascular dementia. Am J Geriatr Cardiol 16 (2007) 165-170
2. Fratiglioni L., De Ronchi D., and Agüero-Torres H. Worldwide prevalence and incidence of dementia. Drugs Aging 15 (1999) 365-375
3. Sloane P.D., Zimmerman S., Suchindran C., Reed P., Wang L., Boustani M., et al. The public health impact of Alzheimer's disease, 2000-2050: potential implication of treatment advances. Annu Rev Public Health 23 (2002) 213-231
4. Sugawara T., Lewén A., Noshita N., Gasche Y., and Chan P.H. Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal CA1 subregion in rats. J Neurotrauma 19 (2002) 85-98
5. Takeo S., Takagi N., and Takagi K. Ischemic brain injury and hepatocyte growth factor. Yakugaku Zasshi 127 (2007) 1813-1823
6. Kuan C.Y., Roth K.A., Flavell R.A., and Rakic P. Mechanisms of programmed cell death in the developing brain. Trends Neurosci 23 (2000) 291-297
7. Northington F.J., Ferriero D.M., Flock D.L., and Martin L.J. Delayed neurodegeneration in neonatal rat thalamus after hypoxia-ischemia is apoptosis. J Neurosci 21 (2001) 1931-1938
8. Waldmeier P.C. Prospects for antiapoptotic drug therapy of neurodegenerative diseases. Prog Neuropsychopharmacol Biol Psychiatry 27 (2003) 303-321
9. Stewart Z.A., and Pietenpol J.A. p53 Signaling and cell cycle checkpoints. Chem Res Toxicol 14 (2001) 243-263
10. Eisenberg D.M., Davis R.B., Ettner S.L., Appel S., Wilkey S., Van Rompay M., et al. Trends in alternative medicine use in the United States, 1990-1997: Results of a follow up national survey. JAMA 280 (1998) 1569-1575
11. Kaptchuck T.J. The Web that has no weaver: understanding Chinese medicine, Lincolnwood: Contemporary Books (2000)
12. Kim E.H., Kim Y.J., Lee H.J., Huh Y., Chung J.H., Seo J.C., et al. Acupuncture increases cell proliferation in dentate gyrus after transient global ischemia in gerbils. Neurosci Lett 297 (2001) 21-24
13. Gao H., Guo J., Zhao P., and Cheng J. The neuroprotective effects of electroacupuncture on for cerebral ischemia in monkey. Acupunct Electrother Res 27 (2002) 45-57
14. Yang Y.J., Kim Y.S., Shin M.S., Chang H.K., Lee T.H., Sim Y.J., et al. Effects of acupuncture on the intrastriatal hemorrhage-induced caspase3 expression and newly cell birth in rats. Neurol Res 29 (2007) S65-71
15. Kim S.T., Jeon S., Park H.J., Hong M.S., Jeong W.B., Kim J.H., et al. Acupuncture inhibits kainic acid-induced hippocampal cell death in mice. J Physiol Sci 58 (2008) 31-38
16. Inoue I., Chen L., Zhou L., Zeng X., and Wang H. Reproduction of scalp acupuncture therapy on strokes in the model rats, spontaneous hypertensive rats-stroke prone (SHR-SP). Neurosci Lett 333 (2002) 191-194
17. Jang M.H., Shin M.C., Koo G.S., Lee C.Y., Kim E.H., and Kim C.J. Acupuncture decreases nitric oxide synthase expression in periaqueductal gray area of rats with streptozotocin-induced diabetes. Neurosci Lett 337 (2003) 155-158
18. Yu J., Zhang X., Liu C., Meng Y., and Han J. Effect of acupuncture on vascular dementia. Neurol Res 28 (2006) 97-103
19. Yu J., Liu C., Zhang X., and Han J. Acupuncture improved cognitive impairment caused by multi-infarct dementia in rats. Physiol Behav 86 (2005) 434-441
20. Liu C.Z., Yu J.C., Zhang X.Z., Fu W.W., Wang T., and Han J.X. Acupuncture prevents cognitive deficits and oxidative stress in cerebral multi-infarction rats. Neurosci Lett 393 (2006) 45-50
21. Cheng H., Yu J., Jiang Z., Zhang X., Liu C., Peng Y., et al. Acupuncture improves cognitive deficits and regulates the brain cell proliferation of SAMP8 mice. Neurosci Lett 432 (2008) 111-116
22. Chung J.H., Lee E.Y., Jang M.H., Kim C.J., Kim J., Ha E., et al. Acupuncture decreases ischemia-induced apoptosis and cell proliferation in dentate gyrus of gerbils. Neurol Res 29 (2007) S23-S27
23. Jang M.H., Shin M.C., Lee T.H., Lim B.V., Shin M.S., Min B.I., et al. Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils. Neurosci Lett 347 (2003) 5-8
24. Kaneko D., Nakamura N., and Ogawa T. Cerebral infarction in rats using homologous blood emboli: development of a new experimental model. Stroke 16 (1985) 76-84
25. Chen J.P., Tian S.Y., and Yu W.W. The studies of multi-infarction dementia in rats: a experimental dementia. Chin J Neurol Psychiat 27 (1994) 311-312
26. Morris R. Developments of a water maze procedure for studying spatial learning in the rat. J Neurosci Methods 11 (1984) 47-60
27. Morris R.G.M. Spatial localization does not require the presence of local cues. Learn Motiv 12 (1981) 239-260
28. Brandeis R., Brandys Y., and Yehuda S. The use of the Morris water maze in the study of memory and learning. Int J Neurosci 48 (1989) 29-69
29. D'Hooge R., and De Deyn P.P. Applications of the Morris water maze in the study of learning and memory. Brain Res Rev 36 (2001) 60-90
30. Whishaw I.Q. Place learning in hippocampal rats and the path integration hypothesis. Neurosci Biobehav Rev 22 (1998) 209-220
31. Moser M.B., Moser E.I., Forrest E., Andersen P., and Morris R.G. Spatial learning with a minislab in the dorsal hippocampus. Proc Natl Acad Sci U S A 92 (1995) 9697-9701
32. Kucukatay V., Balkan S., Yaras N., Yargicoglu P., and Agar A. The effect of pergolide on cognitive performance of young and middle-aged rats. Int J Neurosci 112 (2002) 1027-1036
33. Naghdi N., Majlessi N., and Bozorgmehr T. The effects of anisomycin (a protein synthesis inhibitor) on spatial learning and memory in CA1 region of rats hippocampus. Behav Brain Res 139 (2003) 69-73
34. Steckler T., Drinkenburg W.H., Sahgal A., and Aggleton J.P. Recognition memory in rats: II. Neuroanatomical substrates. Prog Neurobiol 54 (1998) 313-332
35. Lu J., Moochhala S., Kaur C., and Ling E. Changes in apoptosis-related protein (p53, Bax, Bcl-2 and Fos) expression with DNA fragmentation in the central nervous system in rats after closed head injury. Neurosci Lett 290 (2000) 89-92
36. Chen J., Simon R.P., Nagayama T., Zhu R., Loeffert J.E., Watkins S.C., et al. Suppression of endogenous bcl-2 expression by antisense treatment exacerbates ischemic neuronal death. J Cereb Blood Flow Metab 20 (2000) 1033-1039
37. Gillardon F., Lenz C., Waschke K.F., Krajewski S., Reed J.C., Zimmermann M., et al. Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats. Brain Res Mol Brain Res 40 (1996) 254-260
38. Prakasa Babu P., Yoshida Y., Su M., Segura M., Kawamura S., and Yasui N. Immunohistochemical expression of Bcl-2, Bax and cytochrome c following focal cerebral ischemia and effect of hypothermia in rat. Neurosci Lett 291 (2000) 196-200
39. Yang L., Matthews R.T., Schulz J.B., Klockgether T., Liao A.W., Martinou J.C., et al. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2. J Neurosci 18 (1998) 8145-8152
40. Wu C., Fujihara H., Yao J., Qi S., Li H., Shimoji K., et al. Different expression patterns of Bcl-2, Bcl-xl, and Bax proteins after sublethal forebrain ischemia in C57Black/Crj6 mouse striatum. Stroke 34 (2003) 1803-1808
41. Ding X., Yu J., Yu T., Fu Y., and Han J. Acupuncture regulates the aging-related changes in gene profile expression of the hippocampus in senescence-accelerated mouse (SAMP10). Neurosci Lett 399 (2006) 11-16
42. Cho Z.H., Chung S.C., Jones J.P., Park J.B., Park H.J., Lee H.J., et al. New findings of the correlation between acupoints and corresponding brain cortices using functional MRI. Proc Natl Acad Sci USA 95 (1998) 2670-2673
43. Lee J.H., and Beitz A.J. The distribution of brain-stem and spinal cord nuclei associated with different frequencies of electroacupuncture analgesia. Pain 52 (1993) 11-28
44. Cho N.H., Lee J.D., Cheong B.S., Choi D.Y., Chang H.K., Lee T.H., et al. Acupuncture suppresses intrastriatal hemorrhage-induced apoptotic neuronal cell death in rats. Neurosci Lett 362 (2004) 141-145