Peak shapes of acids and bases under overloaded conditions in reversed-phase liquid chromatography, with weakly buffered mobile phases of various pH: A thermodynamic interpretation

Journal of Chromatography A

Volumn 1216, Issue 1, 2009, Pages 63-78

  Gritti, Fabrice ^a,b   Guiochon, Georges ^a,b  

^a UNIVERSITY OF TENNESSEE   (United States)

^b OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

Acids and bases compounds; C18 reversed phase columns; Column heterogeneity; Competitive adsorption isotherms; Nonlinear chromatography; Overloaded band profiles; Silanol activity; Silica; Weak buffer capacity

Indexed keywords

ACIDS; ADSORBENTS; ADSORPTION; ADSORPTION ISOTHERMS; ATMOSPHERIC TEMPERATURE; BUFFER STORAGE; CHLORINE COMPOUNDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; IONIZATION OF LIQUIDS; ISOTHERMS; LIQUID CHROMATOGRAPHY; METHANOL; NITROGEN COMPOUNDS; ORGANIC ACIDS; PH EFFECTS; PHENOLS; SILICA; SURFACE CHEMISTRY;

C18 REVERSED-PHASE COLUMNS; COLUMN HETEROGENEITY; COMPETITIVE ADSORPTION ISOTHERMS; NONLINEAR CHROMATOGRAPHY; OVERLOADED BAND PROFILES; SILANOL ACTIVITY; WEAK BUFFER CAPACITY;

TUNGSTEN COMPOUNDS;

3 PHENYL 1 PROPANOL; ACETIC ACID; AMPHETAMINE; ANILINE; ARYLBUTYRIC ACID DERIVATIVE; BENZYLAMINE; CAFFEINE; CARBONIC ACID; CHLORINE DERIVATIVE; METHANOL; PHENOL; PHOSPHORUS; PROCAINAMIDIUM CHLORIDE; PROPANOL; SILANOL; SILICON DIOXIDE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; PH; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; THERMODYNAMICS;

ADSORPTION; BUFFERS; CHROMATOGRAPHY, LIQUID; HYDROGEN-ION CONCENTRATION; PHARMACEUTICAL PREPARATIONS; SOLUTIONS; THERMODYNAMICS; TIME FACTORS;

EID: 57649187546     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2008.11.020     Document Type: Article

References (40)

1. McCalley D.V. J. Chromatogr. A 708 (1995) 185
2. McCalley D.V. J. Chromatogr. A 738 (1996) 169
3. McCalley D.V. J. Chromatogr. A 793 (1998) 31
4. McCalley D.V. J. Chromatogr. A 987 (2003) 17
5. McCalley D.V. J. Chromatogr. A 1038 (2004) 77
6. Davies N.H., Euerby M.R., and McCalley D.V. J. Chromatogr. A 1119 (2006) 11
7. McCalley D.V. Anal. Chem. 78 (2006) 2532
8. McCalley D.V. Anal. Chem. 75 (2003) 3404
9. Buckenmaier S.M.C., McCalley D.V., and Euerby M.R. Anal. Chem. 74 (2002) 4672
10. Gritti F., and Guiochon G. J. Chromatogr. A 1099 (2005) 1
11. Guiochon G., Shirazi S.G., Felinger A., and Katti A.M. Fundamentals of Preparative and Nonlinear Chromatography (2006), Academic Press, Boston, MA
12. Samuelsson J., Franz A., Stanley B.J., and Fornstedt T. J. Chromatogr. A 1163 (2007) 177
13. Neue U.D., Van Tran K., Mendez A., and Carr P.W. J. Chromatogr. A 1063 (2005) 35
14. Neue U.D., Wheat T.E., Mazzeo J.R., Mazza C.B., Cavanaugh J.Y., Xia F., and Diehl D.M. J. Chromatogr. A 1030 (2004) 123
15. Mendez A., Bosch E., Roses M., and Neue U.D. J. Chromatogr. A 986 (2003) 33
16. Neue U.D., Phoebe C.H., Van Tran K., Cheng Y.-F., and Lu Z. J. Chromatogr. A 925 (2001) 49
17. Gritti F., and Guiochon G. J. Chromatogr. A 1033 (2004) 43
18. Gritti F., and Guiochon G. J. Chromatogr. A 1033 (2004) 57
19. Gritti F., and Guiochon G. J. Chromatogr. A 1047 (2004) 33
20. Gritti F., and Guiochon G. Anal. Chem. 76 (2004) 4779
21. Gritti F., and Guiochon G. J. Chromatogr. A 1048 (2004) 1
22. Gritti F., and Guiochon G. J. Chromatogr. A 1028 (2004) 197
23. Gritti F., and Guiochon G. Anal. Chem. 76 (2004) 7310
24. Gritti F., and Guiochon G. J. Chromatogr. A 1038 (2004) 53
25. Gritti F., and Guiochon G. J. Chromatogr. A 1041 (2004) 63
26. Samuelsson J., Sajonz P., and Fornstedt T. J. Chromatogr. A 1189 (2008) 19
27. Samuelsson J., Zhang J., Murunga A., Fornstedt T., and Sajonz P. J. Chromatogr. A 1194 (2008) 205
28. Aris R., and Amundson N.R. Mathematical Methods in Chemical Engineering (1973), Prentice Hall, Englewood Cliffs, NJ
29. Danckwerts P.W. Chem. Eng. Sci. 2 (1953) 1
30. Rouchon P., Valentin P., Schonauer M., Vidal-Madjar C., and Guiochon G. J. Phys. Chem. 88 (1985) 2709
31. Rouchon P., Schonauer M., Valentin P., and Guiochon G. Sep. Sci. Technol. 22 (1987) 1793
32. Guiochon G., Golshan-Shirazi S., and Jaulmes A. Anal. Chem. 60 (1988) 1856
33. Gritti F., Kazakevich Y., and Guiochon G. J. Chromatogr. A 1161 (2007) 157
34. Gritti F., and Guiochon G. J. Chromatogr. A 1144 (2007) 208
35. Lippa K.A., Sander L.C., and Mountain R.D. Anal. Chem. 77 (2005) 7852
36. Rustamov I., Farcas T., Ahmed F., Chan F., Lobrutto R., McNair H.M., and Kazakevich Y.V. J. Chromatogr. A 913 (2001) 49
37. Rafferty J.L., Zhang L., Siepmann J.I., and Schure M.R. Anal. Chem. 79 (2007) 6551
38. Bosch E., Bou P., Allemann H., and Rosés M. Anal. Chem. 68 (1996) 3651
39. Felinger A., Cavazzini A., and Guiochon G. J. Chromatogr. A 986 (2003) 207
40. Gritti F., and Guiochon G. J. Chromatogr. A 1176 (2007) 107