Frequency and function of CETP variants among individuals of Asian ancestry

Atherosclerosis

Volumn 202, Issue 1, 2009, Pages 241-247

  Thompson, John F ^a   Reynolds, Jennifer M ^a   Williams, Suzanne P ^a   Wood, Linda S ^a   Paciga, Sara A ^a   Lloyd, David B ^a  

^a PFIZER INC   (United States)

Author keywords

Association study; CETP; HDL; Pharmacogenetics

Indexed keywords

CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

AMINO ACID SEQUENCE; ARTICLE; ASIAN; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ETHNICITY; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN TRANSPORT; PROTEIN VARIANT; RNA SPLICING; SINGLE NUCLEOTIDE POLYMORPHISM; WESTERN BLOTTING;

ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CHOLESTEROL ESTER TRANSFER PROTEINS; CHOLESTEROL, HDL; CLONING, MOLECULAR; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; GENETIC VARIATION; HAPLOTYPES; HUMANS; INTRONS; PHARMACOGENETICS; PHENOTYPE; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 57649184072     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.03.013     Document Type: Article

References (36)

1. Boekholdt S.M., and Thompson J.F. Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease. J Lipid Res 44 (2003) 1080-1093
2. Thompson J.F., Wood L.S., Pickering E.H., DeChairo B., and Hyde C.L. High density genotyping and functional SNP localization in the CETP gene. J Lipid Res 48 (2007) 434-443
3. Hirano K., Yamashita S., Nakajima N., et al. Genetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan. Marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity. Arterioscler Thromb Vasc Biol 17 (1997) 1053-1059
4. Takahashi K., Jiang X.C., Sakai N., et al. A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins. J Clin Invest 92 (1993) 2060-2064
5. Zhong S., Sharp D.S., Grove J.S., et al. Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels. J Clin Invest 97 (1996) 2917-2923
6. Arai H., Yamamoto A., Matsuzawa Y., et al. Polymorphisms in four genes related to triglyceride and HDL-cholesterol levels in the general Japanese population in 2000. J Atheroscler Thromb 12 (2005) 240-250
7. Hsu L.-A., Ko Y.-L., Hsu K.-H., Ko Y.-H., and Lee Y.-S. Genetic variations in the cholesteryl ester transfer protein gene and high density lipoprotein cholesterol in Taiwanese Chinese. Hum Genet 110 (2002) 57-63
8. Song G.J., Han G.H., Chae J.J., et al. The effects of the cholesterol ester transfer protein gene and environmental factors on the plasma high density lipoprotein cholesterol levels in the Korean population. Mol Cells 7 (1997) 615-619
9. Thu N.N., Mai T.T., Ohmori R., et al. Effect of the cholesteryl ester transfer protein genotypes on plasma lipid and lipoprotein levels in Vietnamese children. Pediatr Res 58 (2005) 1249-1253
10. Dixit M., and Mittal B. Frequencies of CETP gene TaqI B and D442G polymorphisms in North Indian population. Curr Sci 88 (2005) 1973-1976
11. Nagano M., Yamashita S., Hirano K., et al. Two novel missense mutations in the CETP gene in Japanese hyperalphaproteinemic subjects: high throughput assay by Invader assay. J Lipid Res 43 (2002) 1011-1018
12. Zheng K., Zhang S., Zhang L., et al. Carriers of three polymorphisms of cholesteryl ester transfer protein gene are at increased risk to coronary heart disease in a Chinese population. Int J Cardiol 103 (2005) 259-265
13. Lloyd D.B., Reynolds J.M., Cronan M.T., et al. Novel variants in human and monkey CETP. Biochim Biophys Acta 1737 (2005) 69-75
14. Ballantyne C.M., Andrews T.C., Hsia J.A., Kramer J.H., and Shear C. Correlation of non-high-density lipoprotein cholesterol with apolipoprotein B: effect of 5 hydroxymethylglutaryl coenzyme A reductase inhibitors on non-high-density lipoprotein cholesterol levels. Am J Cardiol 88 (2001) 265-269
15. LaRosa J.C., Grundy S.M., Waters D.D., et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med 352 (2005) 1425-1435
16. Lloyd D.B., Lira M.E., Wood L.S., et al. Cholesteryl ester transfer protein variants have differential stability but uniform inhibition by torcetrapib. J Biol Chem 280 (2005) 14918-14922
17. Thompson J.F., Durham L.K., Lira M.E., Shear C., and Milos P.M. CETP polymorphisms associated with HDL cholesterol may differ from those associated with cardiovascular disease. Atherosclerosis 181 (2005) 45-53
18. Brown M.L., Inazu A., Hesler C.B., et al. Molecular basis of lipid transfer deficiency in a family with increased high-density lipoproteins. Nature 342 (1989) 448-451
19. Curb J.D., Abbott R.D., Rodriguez B.L., et al. A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly. J Lipid Res 45 (2004) 948-953
20. Fumeron F., Betoulle D., Luc G., et al. Alcohol intake modulates the effect of a polymorphism of the cholesteryl ester transfer protein gene on plasma high density lipoprotein and the risk of myocardial infarction. J Clin Invest 96 (1995) 1664-1671
21. Hacia J.G., Fan J.-B., Ryder O., et al. Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density arrays. Nat Genet 22 (1999) 164-167
22. Freeman D.J., Samani N.J., Wilson V., et al. A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study. Eur Heart J 24 (2003) 1833-1842
23. Arashiro R., Katsuren K., Maung K.K., Fukuyama S., and Ohta T. Effect of a common mutation (D442G) of the cholesteryl ester transfer protein gene on lipids and lipoproteins in children. Pediatr Res 50 (2001) 455-459
24. Kimura H., Gejyo F., Suzuki S., et al. Cholesteryl ester transfer protein as a protective factor against vascular disease in hemodialysis patients. Kidney Int 56 (1999) S186-S189
25. Hui S.-P. Frequency and effect on plasma lipoprotein metabolism of a mutation in the cholesteryl ester transfer protein gene in the Chinese. Hokkaido J Med Sci 72 (1997) 319-327
26. Zhuang Y., Wang J., Qiang H., et al. Cholesteryl ester transfer protein levels and gene deficiency in Chinese patients with cardio-cerebrovascular diseases. Chin Med J 115 (2002) 371-374
27. Haraki T., Inazu A., Yagi K., Kajinami K., Koizumi J., and Mabuchi H. Clinical characteristics of double heterozygotes with familial hypercholesterolemia and cholesteryl ester transfer protein deficiency. Atherosclerosis 132 (1997) 229-236
28. Wu J.H., Lee Y.-T., Hsu H.-C., and Hsieh L.-L. Influence of CETP gene variation on plasma lipid levels and coronary heart disease: a survey in Taiwan. Atherosclerosis 159 (2001) 451-458
29. Arai Y., Hirose N., Yamamura K., et al. Deficiency of cholesteryl ester transfer protein and gene polymorphisms of lipoprotein lipase and hepatic lipase are not associated with longevity. J Mol Med 81 (2003) 102-109
30. Inazu A., Jiang X.-C., Haraki T., et al. Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol. J Clin Invest 94 (1994) 1872-1882
31. Choi H.S., Park J.B., Han K.O., et al. A common mutation in cholesteryl ester transfer protein gene and plasma HDL cholesterol level before and after hormone replacement therapy in Korean postmenopausal women. Korean J Int Med 17 (2002) 83-87
32. Akita H., Chiba H., Tsuchihashi K., et al. Cholesteryl ester transfer protein gene: two common mutations and their effect on plasma high-density lipoprotein cholesterol content. J Clin Endo Metab 79 (1994) 1615-1618
33. Jap T.-S., Wu Y.-C., Tso Y.-C., and Chiu C.-Y. A novel mutation in the intron 1 splice donor site of the cholesterol ester transfer protein (CETP) gene as a cause of hyperalphalipoproteinemia. Metabolism 51 (2002) 394-397
34. Zheng K.-Q., Zhang S.-Z., Zhang L., Huang D.-J., Liao L.-C., and Hou Y.-P. A novel missense mutation (L296Q) in cholesteryl ester transfer protein gene related to coronary heart disease. Acta Biochim Biophys Sin 36 (2004) 33-36
35. Wang J., Qiang H., Chen D., Zhang C., and Zhuang Y. CETP gene mutation (D442G) increases low-density lipoprotein particle size in patients with coronary heart disease. Clin Chim Acta 322 (2002) 85-90
36. Xia Y., Baum L., Pang C.P., Siest G., and Visvikis S. Cardiovascular risk-associated allele frequencies for 15 genes in healthy French and Chinese. Clin Chem Lab Med 43 (2005) 817-822