Possibility of topical antioxidant treatment of cataracts: Corneal penetration of pyruvate in humans

Ophthalmologica

Volumn 223, Issue 2, 2009, Pages 136-138

  Chandra, P ^a   Hegde, K R ^b   Varma, S D ^b  

^a DB Chandra Memorial Eye Center   (India)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Aqueous humor; Cataract; Diabetic retinopathy; Sodium pyruvate

Indexed keywords

2,4 DINITROPHENYLHYDRAZINE; ARTIFICIAL TEAR; FLURBIPROFEN; PHENYLEPHRINE; PYRUVATE SODIUM; TEAR PLUS; TOBRAMYCIN; TROPICAMIDE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AQUEOUS HUMOR; ARTICLE; CATARACT; CATARACT EXTRACTION; CLINICAL ARTICLE; CORNEA; DRUG PENETRATION; EXTRACAPSULAR CATARACT EXTRACTION; HUMAN; LENS IMPLANTATION; PHACOEMULSIFICATION;

ADOLESCENT; ADULT; AGED; ANTIOXIDANTS; AQUEOUS HUMOR; CATARACT; CATARACT EXTRACTION; CORNEA; HUMANS; MIDDLE AGED; OPHTHALMIC SOLUTIONS; OXIDATIVE STRESS; PYRUVIC ACID; YOUNG ADULT;

EID: 57649110866     PISSN: 00303755     EISSN: None     Source Type: Journal    
DOI: 10.1159/000184538     Document Type: Article

References (9)

1. Varma SD, Ets TK, Richards RD: Protection against superoxide radicals in the rat lens. Ophthalmic Res 1977;9:421-423.
2. Kowluru RA, Kern TS, Engerman RL, Armstrong D: Abnormalities of retinal metabolism in diabetic rat and experimental galactosemia. 3. Effect of antioxidant diets. Diabetes 1996;45:1233-1237.
3. Resnikoff S, Pascolino D, Etya'ale D, Kocur I, et al: Global data on visual impairment in the year 2000. Bull World Health Organ 2004;82:844-851.
4. Hegde KR, Varma SD: Prevention of cataract in experientially diabetic mice. Mol Cell Biochem 2005;269:115-120.
5. Varma SD, Hegde KR, Kovtun S: Attenuation and delay of diabetic cataracts by antioxidants: effectiveness of pyruvate after onset of cataract. Ophthalmologica 2005;219:309-315.
6. Ayala MN, Soderberg PG: Vitamin E can protect against ultraviolet radiation-induced cataract in albino rats. Ophthalmic Res 2004;36:264-269
7. Creighton MO, Ross WM, Stewart-DeHaan PJ, Sanwal M, Trevithick JR: Modelling cortical cataractogenesis. 7. Effects of vitamin E treatment on galactose-induced cataracts. Exp Eye Res 1985;40:213-222.
8. Monnier VM, Stevens VJ, Cerami A: Nonenzymatic glycosylation, sulfhydryl oxidation and aggregation of lens proteins in experimental sugar cataracts. J Exp Med 1979;150:1098-1107.
9. Case EM: The determination of pyruvic acid. Biochem J 1932;26:753-758.