Biphenotypic acute leukemia with b2a2 fusion transcript and trisomy 21

Cancer Genetics and Cytogenetics

Volumn 188, Issue 2, 2009, Pages 129-131

  Park, Tae Sung ^a   Lee, Seung Tae ^a   Song, Jaewoo ^b   Lee, Kyung A ^b   Kim, Juwon ^b   Park, Yongjung ^b   Song, Sungwook ^b   Choi, Jong Rak ^a  

^a Yonsei University College of Medicine   (South Korea)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BREAKPOINT CLUSTER REGION PROTEIN; HYBRID PROTEIN;

ACUTE BIPHENOTYPIC LEUKEMIA; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; AGED; CASE REPORT; CELL DIFFERENTIATION; CELL LINEAGE; CHROMOSOME ABERRATION; DOWN SYNDROME; EXON; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC TRANSCRIPTION; HUMAN; KARYOTYPE; LETTER; LEUKEMOGENESIS; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRISOMY 21;

ACUTE DISEASE; AGED; CHROMOSOME BANDING; DOWN SYNDROME; FEMALE; HUMANS; KARYOTYPING; LEUKAPHERESIS; LEUKEMIA; ONCOGENE PROTEINS, FUSION; PATIENT DISCHARGE; PEPTIDES; PHENOTYPE; TRANSCRIPTION, GENETIC;

EID: 57549110820     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2008.10.008     Document Type: Letter

References (11)

1. Legrand O., Perrot J.Y., Simonin G., Baudard M., Cadiou M., Blanc C., Ramond S., Viguié F., Marie J.P., and Zittoun R. Adult biphenotypic acute leukaemia: an entity with poor prognosis which is related to unfavourable cytogenetics and P-glycoprotein over-expression. Br J Haematol 100 (1998) 147-155
2. Matutes E., Morilla R., Farahat N., Carbonell F., Swansbury J., Dyer M., and Catovsky D. Definition of acute biphenotypic leukemia. Haematologica 82 (1997) 64-66
3. Bene M.C., Castoldi G., Knapp W., Ludwig W.D., Matutes E., Orfao A., and van't Veer M.B. Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia 9 (1995) 1783-1786
4. Owaidah T.M., Al Beihany A., Iqbal M.A., Elkum N., and Roberts G.T. Cytogenetics, molecular and ultrastructural characteristics of biphenotypic acute leukemia identified by the EGIL scoring system. Leukemia 20 (2006) 620-626
5. Sulak L.E., Clare C.N., Morale B.A., Hansen K.L., and Montiel M.M. Biphenotypic acute leukemia in adults. Am J Clin Pathol 94 (1990) 54-58
6. Killick S., Matutes E., Powles R.L., Hamblin M., Swansbury J., Treleaven J.G., Zomas A., Atra A., and Catovsky D. Outcome of biphenotypic acute leukemia. Haematologica 84 (1999) 699-706
7. Choi H.W., Shin M.G., Kim H.J., Lee I.K., Yun J.H., Kim H.R., Kim Y.K., Yun H.K., Cho D., Kee S.J., Shin J.H., Suh S.P., and Ryang D.W. Biphenotypic acute leukemia with BCR-ABL mRNA transcript b3a2 type: a case report with review of the literature. Korean J Lab Med 26 (2006) 249-254
8. Maru Y. Molecular biology of chronic myeloid leukemia. Int J Hematol 73 (2001) 308-322
9. Jaffe E.S., Harris N.L., Stein H., and Vardiman J.W. Pathology and genetics: tumours of haematopoietic and lymphoid tissues (2001), IARC Press, Lyon
10. Izraeli S., Rainis L., Hertzberg L., Smooha G., and Birger Y. Trisomy of chromosome 21 in leukemogenesis. Blood Cells Mol Dis 39 (2007) 156-159
11. Oka S., Yokote T., Akioka T., Hara S., Kobayashi K., Hirata Y., Hiraoka N., Tsuji M., and Hanafusa T. Trisomy 21 as the sole acquired karyotypic abnormality in biphenotypic acute leukemia. Int J Hematol 85 (2007) 270-272