Cytogenetics, molecular and ultrastructural characteristics of biphenotypic acute leukemia identified by the EGIL scoring system

Leukemia

Volumn 20, Issue 4, 2006, Pages 620-626

  Owaidah, T M ^a   Al Beihany, A ^a   Iqbal, M A ^a   Elkum, N ^a   Roberts, G T ^a  

^a KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

Author keywords

Biphenotypic; Cytogenetic; Immunophenotyping; Leukemia; Molecular

Indexed keywords

ACUTE LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; B CELL LEUKEMIA; BLAST CELL; CELL LINEAGE; CELL STRUCTURE; CHILD; CHROMOSOME 12P; CHROMOSOME 14Q; CHROMOSOME 2Q; CHROMOSOME 6P; CHROMOSOME 6Q; CHROMOSOME 8P; CHROMOSOME ANALYSIS; CHROMOSOME DELETION; CHROMOSOME DELETION 12; CHROMOSOME DELETION 6; CHROMOSOME TRANSLOCATION 14; CHROMOSOME TRANSLOCATION 18; CHROMOSOME TRANSLOCATION 2; CHROMOSOME TRANSLOCATION 22; CHROMOSOME TRANSLOCATION 6; CHROMOSOME TRANSLOCATION 9; CHROMOSOME TRANSLOCATION X; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOCHEMISTRY; CYTOGENETICS; DIAGNOSTIC VALUE; DISEASE CLASSIFICATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; MALE; MOLECULAR GENETICS; MYELOID LEUKEMIA; NUMERICAL CHROMOSOME ABERRATION; PHENOTYPE; PRIORITY JOURNAL; RISK ASSESSMENT; SCORING SYSTEM; T CELL LEUKEMIA;

EID: 33646477994     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404128     Document Type: Article

References (23)

1. Jaffe ES, Harris NL, Stein H, James W. Vardiman, Pathology and Genetics, Tumor of Haematopoietic and Lymphoid Tissues. IARC Press: Lyon, 2001.
2. Bain BJ, Barnett D, Linch D, Matutes E, Reilly JT. Revised guideline on immunophenotyping in acute leukemias and chronic lymphoproliferative disorders. Clin Lab Haem 2002; 24: 1-13.
3. McCulloch EA. Stem cells in normal and leukemic hemopoiesis. Henry Stratton Lecture 1982. Blood 1983; 62: 1-13.
4. Sawyers CL, Denny CT, Witte ON. Leukemia and the disruption of normal hematopoiesis. Cell 1991; 64: 337-350.
5. Thalhammer-Scherrer R, Mitterbauer G, Simonitsch I, Jaeger U, Lechn K, Schneider B et al. The immunophenotype of 325 adult acute leukemias: relationship to morphologic and molecular classification and proposal for a minimal screening program highly predictive for lineage discrimination. Am J Clin Pathol 2002; 117: 380-389.
6. Altman AJ. Clinical features and biological implications of acute mixed lineage (hybrid) leukemias. Am J Pediatr Hematol Oncol 1990; 12: 123-133.
7. Hanson CA, Abaza M, Sheldon S, Ross CW, Schnitzer B, Stoolman LM. Acute biphenotypic leukaemia: Immunophenotypic and cytogenetic analysis. Br J Haematol 1993; 84: 49-60.
8. Bene MC, Castoldi G, Knapp W, Ludwig WD, Matutes E, Orfao A, et al., For the European Group for the Immunological Characterization of Leukemias (EGIL). Proposals for the immunological classification of acute leukemias. Leukemia 1995; 9: 1783-1786.
9. Legrand O, Perrot JY, Simonin G, Baudard M, Cadiou M, Blanc C et al. Adult biphenotypic acute leukemia: An entity with poor prognosis which is related to unfavourable cytogenetics and Pglycoprotein over-expression. Br J Haematol 1998; 100: 147-155.
10. Sulak LE, Clare CN, Morale BA, Hansen KL, Montiel MM. Biphenotypic acute leukemia in adults. Am J Clin Pathol 1990; 94: 54-58.
11. Shen Y, Li J, Xue Y, Zhu M, Lu D, Geng M et al. Acute biphenotypic leukemia in the adults. Zhonghua Zhong Liu Za Zhi 2002; 24: 375-377.
12. Schmitt-Graff A, Jurgens H, Reifenhauser A, Schwamborn D, Gobel U. Childhood biphenotypic leukemia: Detection of mixed lymphoid and myeloid populations in bone marrow specimens. Hum Pathol 1998; 19: 651-656.
13. Buccheri V, Matutes E, Dyer MJS, Catovsky D. Lineage commitment in biphenotypic acute leukemia. Leukemia 1993; 7: 919-927.
14. Killick S, Matutes E, Powles RL, Hamblin M, Swansbury J, Treleaven JG et al. Outcome of biphenotypic acute leukemia. Haematologica 1999; 84: 699-706.
15. Carbonell F, Swansbury J, Min T, Matutes E, Farahat N, Buccheri V et al. Cytogenetic findings in acute biphenotypic leukaemia. Leukemia 1996; 10: 1283-1287.
16. Shetty V, Chitale A, Matutes E, Buccheri V, Morilla R, Catovsky D. Immunological and ultrastructural studies in acute biphenotypic leukemia. J Clin Pathol 1993; 46: 903-907.
17. Moscinski LC, Nowell PC, Hoxie JA, Berger MS, Prytowsky MB. Surface marker analysis and karyotype distinguish acute biphenotypic leukemia from acute myelogenous leukemia expressing terminal deoxynucleotidyl transferase. Cancer 1991; 68: 2161-2168.
18. Brigaudau C, Bilhou-Nabera C. del (6q) abnormalities in lymphoid malignancies. Atlas Genet Cytogenet Oncol Haematol 1998, URL: http://www.infobiogen.fr/services/chromcancer/Anomalies/ del6-qID1148.html.
19. Al-Qurashi F, Owaidah T, Iqbal MA, Aljurf M. Trisomy 4 as the sole karyotypic abnormality in a case of acute biphenotypic leukemia with T-lineage markers in minimally differentiated acute myelocytic leukemia. Cancer Genet Cytogenet 2004; 150: 66-69.
20. Brumpt C, Delabesse E, Beldjord K, Davi F, Cayuela JM, Millien C et al. The incidence of clonal T-cell receptor rearrangements in B-cell precursor acute lymphoblastic leukemia varies with age and genotype. Blood 2000; 96: 2254-2261.
21. Chen Z, Le Paslier D, Dausset J, Degos L, Flandrin G, Cohen D et al. Human T cell gamma genes are frequently rearranged in Blineage acute lymphoblastic leukemias but not in chronic B-cell proliferations. J Exp Med 1987; 165: 1000-1015.
22. Height SE, Swansbury GJ, Matutes E, Treleaven JG, Catovsky D, Dyer MJS. Analysis of clonal rearrangements of the Ig heavy chain locus in acute leukemia. Blood 1996; 87: 5242-5250.
23. Szczepanski T, Willemse MJ, Brinkhof B, van Wering ER, van der Burg M, van Dongen JJM. Comparative analysis of Ig and TCR gene rearrangements at diagnosis and at relapse of childhood precursor B-ALL provides improved strategies for selection of stable PCR targets for monitoring of minimal residual disease. Blood 2002; 99: 2315-2323.