Inherited pelvic organ prolapse in the mouse: Preliminary evaluation of a new murine model

International Urogynecology Journal

Volumn 20, Issue 1, 2009, Pages 19-25

  McNanley, Anna R ^a   Johnson, Aimee M ^a   Flynn, Michael K ^a   Wood, Ronald W ^a   Kennedy, Scott D ^a   Reeder, Jay E ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Genetic; Magnetic resonance imaging; Mouse; Pelvic organ prolapse

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; AUTOSOMAL DOMINANT INHERITANCE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CYSTOCELE; FEMALE; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PELVIC ORGAN PROLAPSE; PHENOTYPE; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 57549089374     PISSN: 09373462     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00192-008-0723-7     Document Type: Article

References (18)

1. Bump RC, Norton PA (1998) Epidemiology and natural history of pelvic floor dysfunction. Obstet Gynecol Clin North Am 25:723-746
2. Subak LL, Waetjen LE, van den Eeden S (2001) Cost of pelvic organ prolapse surgery in the United States. Obstet Gynecol 98:646-661
3. Buchsbaum GM, Duecy EE, Kerr LA et al (2005) Urinary incontinence in nulliparous women and their parous sisters. Obstet Gynecol 106:1253-1258
4. Jack GS, Nikolova G, Vilain E (2005) Familial transmission of genitovaginal prolapse. Int Urogynecol J Pelvic Floor Dysfunct 20:1-4
5. Kim S, Harvey MA, Johnston S (2005) A review of the epidemiology and pathophysiology of pelvic floor dysfunction: Do racial differences matter. J Obstet Gynecol 27:251-259
6. Dietz HP (2003) Do Asian women have less pelvic organ mobility than Caucasians? Int Urogynecol J Pelvic Floor Dysfunct 14:250-253
7. Nikolova G, Lee H, Berkovitz S et al (2007) Sequence variant in the laminin γ1 (LAMC 1) gene associated with familial pelvic organ prolapse. Hum Genet 120:847-856
8. Visco AG, Yuan L (2003) Differential gene expression in pubococcygeus muscle from patients with pelvic organ prolapse. Am J Obstet Gynecol 189:102-112
9. Kramer L, Gendron J, Pierce L et al (2006) Magnetic resonance imaging of the levator ani in the squirrel monkey: A comparison of muscle volume between a cohort with pelvic organ prolapse and matched normals. Am J Obstet Gynecol 194:1467-1471
10. Mattson J, Kuehl T, Yandell P et al (2005) Evaluation of the aged female baboon as a model of pelvic organ prolapse and pelvic reconstructive surgery. Am J Obstet Gynecol 192:1395-1398
11. Zhang ZT, Pak J, Shapiro E, Sun TT, Wu XR (1999) Urothelium-specific expression of an oncogene in transgenic mice induced carcinoma in situ and invasive transitional cell carcinoma. Cancer Res 59:3512-3517
12. Johnson AM, Conover DL, Huang J, Messing EM, Ning R, O'Connell MJ, Rossi MA, Sun TT, Wood RW, Wu XR, Reeder JE (2006) Early detection and measurement of urothelial tumors in mice. Urology 67:1309-1314
13. Weber AM, Buchsbaum GM, Chen B (2004) Basic science and translational research in female pelvic floor disorders: Proceedings of an NIH-sponsored meeting. Neurourol Urodyn 23:288-301
14. Birch C, Fynes MM (2002) The role of synthetic and biologic prostheses in reconstructive pelvic floor surgery. Curr Opin Obstet Gynecol 14:527-535
15. Liu X, Zhao Y, Gao J et al (2004) Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet 36:178-182
16. Drewes PG, Yanagisawa H, Starcher B et al (2007) Pelvic organ prolapse in fibulin-5 knockout mice: Pregnancy-induced changes in elastic fiber homeostasis in mouse vagina. Am J Pathol 170:578-589
17. Xiaoqing L, Zhao Y, Pawlyk B (2006) Failure of elastic fiber homeostasis leads to pelvic floor disorders. Am J Pathol 168:519-527
18. Connell K, Guess M, Chen H et al (2008) HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. J Clin Invest 118:1050-1055