Growth arrest and DNA damage protein 45b (Gadd45b) protects retinal ganglion cells from injuries

Neurobiology of Disease

Volumn 33, Issue 1, 2009, Pages 104-110

  Liu, Bin ^a   Suyeoka, Genn ^a   Papa, Salvatore ^b   Franzoso, Guido ^b   Neufeld, Arthur H ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Faculty of Medicine   (United Kingdom)

Author keywords

Aging; Excitotoxicity; Gadd45b; Glaucoma; Neurodegeneration; Neuroprotection; Oxidative stress; TNF

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45B; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; EXCITOTOXICITY; INTRAOCULAR PRESSURE; MALE; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RETINA; RETINA GANGLION CELL; UPREGULATION;

AGING; ANIMALS; ANTIGENS, DIFFERENTIATION; CELL DEATH; CELLS, CULTURED; GLUTAMIC ACID; INTRAOCULAR PRESSURE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDATIVE STRESS; PARAQUAT; RATS; RATS, WISTAR; RETINA; RETINAL GANGLION CELLS; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 57449105203     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2008.09.020     Document Type: Article

References (26)

1. Barker V., Middleton G., Davey F., and Davies A.M. TNFalpha contributes to the death of NGF-dependent neurons during development. Nat. Neurosci. 4 (2001) 1194-1198
2. Befort K., Karchewski L., Lanoue C., and Woolf C.J. Selective up-regulation of the growth arrest DNA damage-inducible gene Gadd45 alpha in sensory and motor neurons after peripheral nerve injury. Eur. J. Neurosci. 18 (2003) 911-922
3. De S.E., Zazzeroni F., Papa S., Nguyen D.U., Jin R., Jones J., Cong R., and Franzoso G. Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling. Nature 414 (2001) 308-313
4. Frassetto L.J., Schlieve C.R., Lieven C.J., Utter A.A., Jones M.V., Agarwal N., and Levin L.A. Kinase-dependent differentiation of a retinal ganglion cell precursor. Invest. Ophthalmol. Vis. Sci. 47 (2006) 427-438
5. Gupta M., Gupta S.K., Hoffman B., and Liebermann D.A. Gadd45a and Gadd45b protect hematopoietic cells from UV-induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition. J. Biol. Chem. 281 (2006) 17552-17558
6. Gupta S.K., Gupta M., Hoffman B., and Liebermann D.A. Hematopoietic cells from gadd45a-deficient and gadd45b-deficient mice exhibit impaired stress responses to acute stimulation with cytokines, myeloablation and inflammation. Oncogene 25 (2006) 5537-5546
7. Kerrigan L.A., Zack D.J., Quigley H.A., Smith S.D., and Pease M.E. TUNEL-positive ganglion cells in human primary open-angle glaucoma. Arch. Ophthalmol. 115 (1997) 1031-1035
8. Laabich A., Li G., and Cooper N.G. Characterization of apoptosis-genes associated with NMDA mediated cell death in the adult rat retina. Brain Res. Mol. Brain Res. 91 (2001) 34-42
9. Lemberger T., Parkitna J.R., Chai M., Schutz G., and Engblom D. CREB has a context-dependent role in activity-regulated transcription and maintains neuronal cholesterol homeostasis. FASEB J. 22 (2008) 2872-2879
10. Liebermann D.A., and Hoffman B. Gadd45 in the response of hematopoietic cells to genotoxic stress. Blood Cells Mol. Dis. 39 (2007) 344-347
11. Liu B., Chen H., Johns T.G., and Neufeld A.H. Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after neural injury. J. Neurosci. 26 (2006) 7532-7540
12. Mattson M.P., and Magnus T. Ageing and neuronal vulnerability. Nat. Rev. Neurosci. 7 (2006) 278-294
13. Nakazawa T., Nakazawa C., Matsubara A., Noda K., Hisatomi T., She H., Michaud N., Hafezi-Moghadam A., Miller J.W., and Benowitz L.I. Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma. J. Neurosci. 26 (2006) 12633-12641
14. Neufeld A.H., and Gachie E.N. The inherent, age-dependent loss of retinal ganglion cells is related to the lifespan of the species. Neurobiol. Aging 24 (2003) 167-172
15. nis-Oliveira R.J., Sousa C., Remiao F., Duarte J.A., Ferreira R., Sanchez N.A., Bastos M.L., and Carvalho F. Sodium salicylate prevents paraquat-induced apoptosis in the rat lung. Free Radic. Biol. Med. 43 (2007) 48-61
16. Papa S., Monti S.M., Vitale R.M., Bubici C., Jayawardena S., Alvarez K., De S.E., Dathan N., Pedone C., Ruvo M., and Franzoso G. Insights into the structural basis of the GADD45beta-mediated inactivation of the JNK kinase, MKK7/JNKK2. J. Biol. Chem. 282 (2007) 19029-19041
17. Papa S., Zazzeroni F., Pham C.G., Bubici C., and Franzoso G. Linking JNK signaling to NF-kappaB: a key to survival. J. Cell. Sci. 117 (2004) 5197-5208
18. Papa S., Zazzeroni F., Fu Y.X., Bubici C., Alvarez K., Dean K., Christiansen P.A., Anders R.A., and Franzoso G. Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling. J. Clin. Invest. 118 (2008) 1911-1923
19. Quigley H.A., Nickells R.W., Kerrigan L.A., Pease M.E., Thibault D.J., and Zack D.J. Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest. Ophthalmol. Vis. Sci. 36 (1995) 774-786
20. Uberti D., Meli E., and Memo M. Expression of cell-cycle-related proteins and excitoxicity. Amino Acids 23 (2002) 27-30
21. Vairapandi M. Characterization of DNA demethylation in normal and cancerous cell lines and the regulatory role of cell cycle proteins in human DNA demethylase activity. J. Cell Biochem. 91 (2004) 572-583
22. Vairapandi M., Balliet A.G., Fornace Jr. A.J., Hoffman B., and Liebermann D.A. The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1. Oncogene 12 (1996) 2579-2594
23. Wang A.L., Yuan M., and Neufeld A.H. Age-related changes in neuronal susceptibility to damage: comparison of the retinal ganglion cells of young and old mice before and after optic nerve crush. Ann. N. Y. Acad. Sci. 1097 (2007) 64-66
24. Yoo J., Ghiassi M., Jirmanova L., Balliet A.G., Hoffman B., Fornace Jr. A.J., Liebermann D.A., Bottinger E.P., and Roberts A.B. Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation. J. Biol. Chem. 278 (2003) 43001-43007
25. Yuan L., and Neufeld A.H. Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head. Glia 32 (2000) 42-50
26. Zazzeroni F., Papa S., geciras-Schimnich A., Alvarez K., Melis T., Bubici C., Majewski N., Hay N., De S.E., Peter M.E., and Franzoso G. Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis. Blood 102 (2003) 3270-3279