Concomitant treatment with lamivudine renders cladribine inactive by inhibition of its phosphorylation

British Journal of Haematology

Volumn 144, Issue 1, 2009, Pages 136-137

  Chtioui, Haithem ^a   Millius, Claudine ^a   Lämmle, Bernhard ^a   Lauterburg, Bernhard H ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Chronic lymphocytic leukaemia; Cladribine; Drug interaction; Lamivudine; Phosphorylation

Indexed keywords

CLADRIBINE; LAMIVUDINE;

ADULT; B CELL LEUKEMIA; CASE REPORT; CHRONIC LYMPHATIC LEUKEMIA; DRUG INACTIVATION; DRUG INHIBITION; DRUG WITHDRAWAL; HEPATITIS B; HUMAN; HUMAN CELL; LETTER; LYMPHOCYTE COUNT; PHOSPHORYLATION; PRIORITY JOURNAL; TREATMENT DURATION;

ANTINEOPLASTIC AGENTS; CLADRIBINE; DRUG INTERACTIONS; HUMANS; LAMIVUDINE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; PHOSPHORYLATION; TREATMENT FAILURE;

EID: 57449098861     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2008.07432.x     Document Type: Letter

References (9)

1. Albertioni, F., Lindemalm, S., Reichelova, V., Pettersson, B., Eriksson, S., Juliusson, G. Liliemark, J. (1998) Pharmacokinetics of cladribine in plasma and its 5′-monophosphate and 5′-triphosphate in leukemic cells of patients with chronic lymphocytic leukemia. Clinical Cancer Research, 4, 653 658.
2. Arner, E.S., Spasokoukotskaja, T. Eriksson, S. (1992) Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues. Biochemical and Biophysical Research Communications, 188, 712 718.
3. Arner, E.S., Spasokoukotskaja, T., Juliusson, G., Liliemark, J. Eriksson, S. (1994) Phosphorylation of 2-chlorodeoxyadenosine (CdA) in extracts of peripheral blood mononuclear cells of leukaemic patients. British Journal of Haematology, 87, 715 718.
4. Beutler, E. (1992) Cladribine (2-chlorodeoxyadenosine). Lancet, 340, 952 956.
5. Ives, D.H. Wang, S.M. (1978) Deoxycytidine kinase from calf thymus. Methods in Enzymology, 51, 337 345.
6. Johnson, M.A., Moore, K.H., Yuen, G.J., Bye, A. Pakes, G.E. (1999) Clinical pharmacokinetics of lamivudine. Clinical Pharmacokinetics, 36, 41 66.
7. Kewn, S., Hoggard, P.G., Sales, S.D., Johnson, M.A. Back, D.J. (2000) The intracellular activation of lamivudine (3TC) and determination of 2′-deoxycytidine-5′-triphosphate (dCTP) pools in the presence and absence of various drugs in HepG2 cells. British Journal of Clinical Pharmacology, 50, 597 604.
8. Kohrt, H.E., Ouyang, D.L. Keeffe, E.B. (2006) Systematic review: lamivudine prophylaxis for chemotherapy-induced reactivation of chronic hepatitis B virus infection. Alimentary Pharmacology & Therapeutics, 24, 1003 1016.
9. Sonderegger, T., Betticher, D.C., Cerny, T. Lauterburg, B.H. (2000) Pharmacokinetics of 2-chloro-2′-deoxyadenosine administered subcutaneously or by continuous intravenous infusion. Cancer Chemotherapy and Pharmacology, 46, 40 42.