Population pharmacokinetic analysis of ibuprofen enantiomers in preterm newborn infants

Journal of Clinical Pharmacology

Volumn 48, Issue 12, 2008, Pages 1460-1468

  Gregoire, Nicolas ^a   Desfrere, Luc ^b   Roze, Jean Christophe ^a   Kibleur, Yves ^c   Koehne, Petra ^d  

^a INSERM   (France)

^b HÔPITAL LOUIS MOURIER   (France)

^c Orphan Europe   (France)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Ibuprofen enantiomers; Population pharmacokinetics; Preterm newborn infants

Indexed keywords

IBUPROFEN;

AGE; ARTICLE; DEMOGRAPHY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG TRANSFORMATION; ENANTIOMER; FEMALE; HUMAN; INDIVIDUALIZATION; INFANT; INTERINDIVIDUAL VARIABILITY; LOADING DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; MONTE CARLO METHOD; PATENT DUCTUS ARTERIOSUS; POSTNATAL AGE; PREMATURITY; PROPHYLAXIS; REPEATED DRUG DOSE; SEX RATIO;

ALGORITHMS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLINICAL TRIALS AS TOPIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HALF-LIFE; HUMANS; IBUPROFEN; INFANT, NEWBORN; INFANT, PREMATURE; MALE; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; MONTE CARLO METHOD; RESEARCH DESIGN; SOFTWARE; STEREOISOMERISM;

EID: 57449098215     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270008323752     Document Type: Article

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