Determinants and impact of multidrug antibiotic resistance in pathogens causing ventilator-associated-pneumonia

Critical Care

Volumn 12, Issue 6, 2008, Pages

  Depuydt, Pieter O ^a   Vandijck, Dominique M ^a   Bekaert, Maarten A ^b   Decruyenaere, Johan M ^a   Blot, Stijn I ^a   Vogelaers, Dirk P ^a   Benoit, Dominique D ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMOXICILLIN PLUS CLAVULANIC ACID; BETA LACTAM ANTIBIOTIC; CARBAPENEM; CEPHALOSPORIN; EXTENDED SPECTRUM BETA LACTAMASE; POLYPEPTIDE ANTIBIOTIC AGENT; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ACINETOBACTER BAUMANNII; ADULT; ANTIBIOTIC RESISTANCE; ARTICLE; ARTIFICIAL VENTILATION; COMORBIDITY; CONTROLLED STUDY; DISEASE SEVERITY; ENTEROBACTERIACEAE; FEMALE; GRAM STAINING; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MORTALITY; MULTIDRUG RESISTANCE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PATHOGENESIS; PREDICTION; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RENAL REPLACEMENT THERAPY; SEPTIC SHOCK; UNIVERSITY HOSPITAL; VENTILATOR ASSOCIATED PNEUMONIA; AGED; BELGIUM; COHORT ANALYSIS; DRUG EFFECT; MICROBIOLOGY; MIDDLE AGED; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; RISK; RISK FACTOR;

AGED; BELGIUM; COHORT STUDIES; DRUG RESISTANCE, BACTERIAL; DRUG RESISTANCE, MULTIPLE; FEMALE; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; PNEUMONIA, VENTILATOR-ASSOCIATED; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 57449089910     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc7119     Document Type: Article

References (44)

1. American Thoracic Society Guidelines for the management of adults with hospital-acquired, ventilator-associated, and health-care associated pneumonia Am J Respir Crit Care Med 2005, 171:388-416. 10.1164/ rccm.200405-644ST 15699079
2. Chastre J Fagon JY Ventilator-associated pneumonia Am J Respir Crit Care Med 2002, 165:867-903. 11934711
3. Rello J Ollendorf D Oster G Vera-Llonch M Bellm L Redman R Kollef MH Epidemiology and outcomes of ventilator-associated pneumonia in a large US database Chest 2002, 122:2115-2121. 10.1378/chest.122.6.2115 12475855
4. Fagon JY Chastre J Vuagnat A Trouillet JL Novara A Gibert C Nosocomial pneumonia and mortality among patients in intensive care units JAMA 1996, 275:866-869. 10.1001/jama.275.11.866 8596225
5. Bergmans DC Bonten MJ Gaillard CA van Tiel FH Geest van der S de Leeuw PW Stobberingh EE Indications for antibiotic use in ICU patients: A one-year prospective study J Antimicrob Chemother 1997, 39:527-535. 10.1093/jac/39.4.527 9145828
6. Safdar N Dezfulian C Collard H Saint S Clinical and economic consequences of ventilator-associated pneumonia: A systematic review Crit Care Med 2005, 33:2184-2193. 10.1097/01.CCM.0000181731.53912.D9 16215368
7. Kollef MH Ventilator-associated pneumonia: A multivariate analysis JAMA 1993, 270:1964-1970. 10.1001/jama.270.16.1965
8. Rello J Quintana E Ausina V Castella J Luquin M Net A Prats G Incidence, etiology, and outcome of nosocomial pneumonia in mechanically ventilated patients Chest 1991, 100:439-444. 10.1378/chest.100.2.439 1864118
9. Tejerina E Frutos-Vivar F Restrepo M Anzueta A Abroug F Palizas F Gonzalez M D'Empaire G Apezteguia C Esteban A Incidence, risk factors, and outcome of ventilator-associated pneumonia J Crit Care 2006, 21:56-65. 10.1016/j.jcrc.2005.08.005 16616625
10. Kollef MH Sherman G Ward S Fraser VJ Inadequate antimicrobial treatment of infections: A risk factor for hospital mortality among critically ill patients Chest 1999, 115:462-474. 10.1378/chest.115.2.462 10027448
11. Alvarez-Lerma F Alvarez B Luque P Ruiz F Dominguez-Roldan JM Quintana E Sanz-Rodriguez C Empiric broad-spectrum antibiotic therapy of nosocomial pneumonia in the intensive care unit: A prospective observational study Crit Care 2006, 10:R78. 1550932 16704742 10.1186/cc4919
12. Iregui M Ward S Sherman G Fraser VJ Kollef MH Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia Chest 2002, 122:262-268. 10.1378/ chest.122.1.262 12114368
13. Harbarth S Garbino J Pugin J Romand JA Lew D Pittet D Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis Am J Med 2003, 115:529-535. 10.1016/j.amjmed.2003.07.005 14599631
14. Rello J Rue M Jubert P Muses G Sonora R Valles J Niederman MS Survival in patients with nosocomial pneumonia: Impact of the severity-of-illness and the etiologic agent Crit Care Med 1997, 25:1862-1867. 10.1097/ 00003246-199711000-00026 9366771
15. Rello J Sole-Violan J Sa-Borges M Garnacho-Montero J Munoz E Sirgo G Olona M Diaz E Pneumonia caused by oxacillin-resistant Staphylococcus aureus treated with glycopeptides Crit Care Med 2005, 33:1983-1987. 10.1097/01.CCM.0000178180.61305.1D 16148469
16. Combes A Luyt CE Fagon JY Wolff M Trouillet JL Chastre J Impact of piperacillin resistance on the outcome of Pseudomonas ventilator-associated pneumonia Intensive Care Med 2006, 32:1970-1978. 10.1007/s00134-006-0355-7 16957901
17. Combes A Luyt CE Fagon JY Wolff M Trouillet JL Gibert C Chastre J Impact of methicillin resistance on outcome of Staphylococcus aureus ventilator-associated pneumonia Am J Respir Crit Care Med 2004, 170:786-792. 10.1164/rccm.200403-346OC 15242840
18. Zahar JR Clec'h C Tafflet M Garrouste-Orgeas M Jamali S Mourvillier B De Lassence A Descorps-Declere A Adrie C de Beauregard MAC Azoulay E Schwebel C Timsit JF Is methicillin resistance associated with a worse prognosis in Staphylococcus aureus ventilator-associated pneumonia? Clin Infect Dis 2005, 41:1224-1231. 10.1086/496923 16206094
19. Blot S Depuydt P Vandewoude K De Bacquer D Measuring the impact of multi-drug resistance in nosocomial infection Curr Opin Infect Dis 2007, 20:391-396. 10.1097/QCO.0b013e32818be6f7 17609598
20. Trouillet JL Chastre J Vuagnat A Joly-Guillou ML Combaux D Dombret MC Gibert C Ventilator-associated pneumonia caused by potentially drug-resistant bacteria Am J Respir Crit Care Med 1998, 157:531-539. 9476869
21. Fine J Gray R A proportional hazards model for the subdistribution of a competing risk J Am Statist Assoc 1999, 94:496-509. 10.2307/2670170
22. Depuydt P Blot S Benoit D Claeys G Verschraegen G Vandewoude K Vogelaers D Decruyenaere J Colardyn F Antimicrobial resistance in nosocomial bloodstream infection associated with pneumonia and the value of systematic surveillance cultures in an adult intensive care unit Crit Care Med 2006, 34:653-659. 10.1097/01.CCM.0000201405.16525.34 16505649
23. Depuydt P Benoit D Vogelaers D Claeys G Verschraegen G Vandewoude K Decruyenaere J Blot S Outcome in bacteremia associated with nosocomial pneumonia and the impact of pathogen prediction by tracheal surveillance cultures Intensive Care Med 2006, 32:1773-1781. 10.1007/ s00134-006-0354-8 16983549
24. Clinical and Laboratory Standards Institute Performance standards for antimicrobial disk susceptibility tests CLSI/NCCLS M100-S15 Wayne, PA; Clinical and Laboratory Standards Institute 2005.
25. Depuydt P Benoit D Vogelaers D Decruyenaere J Vandijck D Claeys G Verschraegen G Blot S Prospective evaluation of systematic surveillance cultures as a tool to predict involvement of multidrug antibiotic resistant bacteria in ventilator-associated pneumonia Intensive Care Medicine 2008, 34:675-682. 10.1007/s00134-007-0953-z 18066522
26. Charlson M Pompei P Ales K MacKenzie CR A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation J Chronic Dis 1987, 40:373-383. 10.1016/0021-9681(87)90171-8 3558716
27. Poses RM McClish DK Smith WR Bekes C Scott WE Prediction of survival of critically patients by admission comorbidity J Clin Epidemiol 1996, 49:743-747. 10.1016/0895-4356(96)00021-2 8691223
28. Pugin J Auckenthaler R Mili N Janssens JP Lew PD Suter PM Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid Am Rev Respir Dis 1991, 143:1121-1129. 2024824
29. Vincent JL De Mendonca A Cantraine F Moreno R Takala J Suter PM Sprung CL Colardyn F Blecher S Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: Results of a multicenter, prospective study Crit Care Med 1998, 26:1793-1800. 9824069
30. Sauaia A Moore FA Moore EE Haenel JB Kaneer L Read RA Diagnosing pneumonia in mechanically ventilated patients: Endotracheal aspirate versus bronchoalveolar lavage J Trauma 1993, 4:512-517.
31. Fujitani S Yu V Quantitative cultures for diagnosing ventilator-associated pneumonia: A critique Clin Infect Dis 2006, 43:S106-S113. 10.1086/504488 16894512
32. Bernard MS Artigas A Brigham KL Carlet J Falke K Hudson L Lamy M Legall JR Morris A Spraggs R Cochin B Lanken PN Leeper KV Marini J Murray JF Oppenheimer L Pesenti A Reid L Rinaldo J Villar J Vanasbeck BS Dhainaut JF Mancebo J Matthay M Meyrick B Payen D Perret C Fowler AA Schaller MD Hudson LD et al. Report on the American-European Consensus Conference on acute respiratory distress syndrome: Definitions, mechanisms, relevant outcomes, and clinical trial coordination Am J Respir Crit Care Med 1994, 158:818-824.
33. Wolkewitz M Vonberg RP Grundmann H Beyersmann J Gastmeier P Barwolff S Geffers C Behnke M Ruden H Schumacher M Risk factors for the development of nosocomial pneumonia and mortality on intensive care units: application of competing risks models Crit Care 2008, 12:R44. 2447589 18384672 10.1186/cc6852
34. Resche-Rigon M Azoulay E Chevret S Evaluating mortality in intensive care units: Contribution of competing risks analyses Crit Care 2006, 10:R5. 1550827 16356211 10.1186/cc3921
35. Satagopan JM Ben-Porat L Berwick M Robson M Kutler D Auerbach AD A note on competing risks in survival data analysis Br J Cancer 2004, 91:1229-1235. 10.1038/sj.bjc.6602102 15305188
36. Chevret S Logistic or Cox model to identify risk factors of nosocomial infection: Still a controversial issue Intensive Care Med 2001, 27:1559-1560. 10.1007/s001340101066 11685293
37. R Foundation for Statistical Computing R: A language and environment for statistical computing (version 2.0.1) http://www.R-project.org
38. cmprsk package http://biowww.dfci.harvard.edu/~gray/cmprsk_2.1-4.tar.gz
39. Rello J Ausina V Ricart M Castella J Prats G Impact of previous antimicrobial therapy on the etiology and outcome of ventilator-associated pneumonia Chest 1993, 104:1230-1235. 10.1378/ chest.104.4.1230 8404198
40. Hoth JJ Franklin GA Stassen NA Girard SM Rodriguez RJ Rodriguez JL Prophylactic antibiotics adversely affect nosocomial infection in trauma patients J Trauma 2003, 55:249-254. 10.1097/01.TA.0000083334.93868.65 12913633
41. Blot S Vandewoude K De Bacquer D Colardyn F Nosocomial bacteremia caused by antibiotic-resistant gram-negative bacteria in critically ill patients: Clinical outcome and length of hospitalization Clin Infect Dis 2002, 34:1600-1606. 10.1086/340616 12032895
42. Garrouste-Orgéas M Timsit JF Tafflet M Misset B Zahar JR Soufir L Lazard T Jamali S Mourvillier B Cohen Y De Lassence A Azoulay E Cheval C Descorps-Declere A Adrie C de Beauregard MAC Carlet J Excess risk of death from intensive care unit-acquired nosocomial bloodstream infections: A reappraisal Clin Infect Dis 2006, 42:1118-1126. 10.1086/ 500318 16575729
43. Metnitz PG Krenn CG Stelzer H Lang T Ploder J Lenz K Le Gall JR Druml W Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients Critical Care Med 2002, 30:2051-2058. 10.1097/00003246-200209000-00016
44. Harris AD Karchmer TB Carmely Y Samore MH Methodological principles of case-control studies that analyzed risk factors for antibiotic resistance: A systematic review Clin Infect Dis 2001, 32:1055-1061. 10.1086/319600 11264034