Toxicological evaluation of the immune function of pesticide workers, a European wide assessment

Human and Experimental Toxicology

Volumn 27, Issue 9, 2008, Pages 701-707

  Steerenberg, P ^a   Van Amelsvoort, L ^b   Colosio, C ^c   Corsini, E ^c   Fustinoni, S ^c   Vergieva, T ^d   Zaikov, C ^d   Pennanen, S ^e   Liesivuori, J ^e   Van Loveren, H ^a,b  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF MILAN   (Italy)

^d National Center of Public Health Protection Bulgaria   (Bulgaria)

^e FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

Author keywords

Epidemiology; Multicentre study; Pesticides

Indexed keywords

2 IMIDAZOLIDINETHIONE; AUTOANTIBODY; COMPLEMENT; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; CREATININE; HEMOGLOBIN; HEPATITIS VACCINE; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G4; MANEB; PESTICIDE; ZINEB;

ADULT; AGRICULTURAL WORKER; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNITY; BULGARIA; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CREATININE URINE LEVEL; DRUG URINE LEVEL; EOSINOPHIL COUNT; ERYTHROCYTE COUNT; EUROPEAN UNION; FEMALE; FINLAND; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN BLOOD LEVEL; HEPATITIS B; HUMAN; IMMUNE SYSTEM; IMMUNITY; IMMUNOTOXICITY; ITALY; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; MONOCYTE; NATURAL KILLER CELL; NETHERLANDS; NEUTROPHIL COUNT; OCCUPATIONAL EXPOSURE; POTATO; PRIORITY JOURNAL; THROMBOCYTE COUNT; TOXICOLOGY; URINARY EXCRETION; VACCINATION; VINEYARD;

ADULT; AGRICULTURE; BLOOD CELL COUNT; BULGARIA; CREATININE; ETHYLENEBIS(DITHIOCARBAMATES); ETHYLENETHIOUREA; FINLAND; HUMANS; IMMUNE SYSTEM; IMMUNITY; ITALY; NETHERLANDS; OCCUPATIONAL EXPOSURE; PESTICIDES; RISK ASSESSMENT;

SOLANUM TUBEROSUM;

EID: 57449089781     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327108095993     Document Type: Article

References (32)

1. Voccia I. Blakley B. Brousseau P. Fournier M.. Immunotoxicity of pesticides: a review. Toxicol Ind Health 1999 ; 15: 119-132.
2. Sobel ES. Gianini J. Butfilski EJ. Croker BP. Schiffenbauer J. Roberts SM.. Acceleration of autoimmunity by organochlorine pesticides in (NZB × NZB)F1 mice. Environ Health Perspect 2005 ; 113: 323-328.
3. Repetto R. Baliga SS.. Pesticides and immunosuppression: the risks to public health. Health Policy Plan 1997 ; 12: 97-106.
4. Botham PA.. Are pesticides immunotoxic. Adverse Drug Reac Acute Poisoning Rev 1990 ; 9: 91-101.
5. Klemmer HW. Wong L. Sato MM. Reichert EL. Korsak RJ. Rashad MN.. Clinical finding in workers exposed to pentachlorophenol. Arch Environ Contam Toxicol 1980 ; 9: 715-725.
6. McConnachie PR. Zahlsky AC.. Immunological consequences of exposure to pentachlorophenol. Arch Environ Health 1991 ; 46: 249-253.
7. Colosio C. Maroni M. Barcellini W.. Toxicological and immune findings in workers exposed to pentachlorophenol (PCP). Arch Environ Health 1993 ; 48: 81-88.
8. Daniel V. Huber W. Bauer K. Opelz G.. Impaired in-vitro lymphocyte responses in patients with elevated pentachlorophenol (PCP) blood levels. Arch Environ Health 1995 ; 50: 287-292.
9. Querioz ML. Bincoletto C. Perlingeiro RC. Quadros MR. Souza CA.. Immunoglobulin levels in workers exposed to hexachlorobenzene. Hum Exp Toxicol 1998 ; 17: 172-175.
10. Michielsen CC. van Loveren H. Vos JG.. The role of the immune system in hexachlorobenzene-induced toxicity. Environ Health Perspect 1999 ; 107 (Suppl. 5): 783-792.
11. Maroni M. Colosio C. Ferioli A. Fait A.. Biological monitoring of pesticide exposure: a review. Toxicology 2000 ; 143: 1-123.
12. Colosio C. Visentin S. Birindelli S. Campo L. Fustinoni S. Mariani F.. Reference values for ethylenethiourea in urine in Northern Italy: results of a pilot study. Toxicol Lett 2006 ; 162: 153-157.
13. Pruett SB. Barnes DB. Han YC. Munson AE.. Immunotoxicological characteristic of sodium methyldithiocarbamate. Fundam Appl Toxicol 1992 ; 18: 40-47.
14. Padget EL. Barnes DB. Pruett SB.. Disparate effects of representative dithiocarbamates on selected immunological parameters in vivo and cell survival in vitro female B6C3F1 mice. J Toxicol Environ Health 1992 ; 37: 559-571.
15. Lombardi P. Fournier M. Bernier J. Mansour S. Neveu P. Krzystyniak K.. Evaluation of the immunodulatory potential of diethyl dithiocarbamate derivatives. Int J Immunopharmacol 1991 ; 13: 1073-1084.
16. Renoux G. Renoux M. Giullamin JM.. Short communication: immunopharmacology and immunotoxicity od zinc diethylthiocarbamate. Int J Immunopharmacol 1988 ; 4: 489-493.
17. Renoux G. Renoux M.. The effects of sodium diethyldithiocarbamate, azathioprine, cyclophosphamide, or hydrocortisone acetate administration alone or in association for 4 weeks on the immune response of Balb/c mice. Clin Immunol Immunophatol 1980 ; 15: 23-32.
18. Colosio C. Barcellini W. Maroni M. Alcini D. Bersani M. Cavallo D.. Immunomodulatory effects of occupational exposure to Mancozeb. Arch Environ Health 1996 ; 51: 445-451.
19. Corsini E. Birindelli S. Fustinoni S. De Paschale G. Mammone T. Visentin S.. Immunomodulatory effects of the fungicide Mancozeb in agricultural workers. Toxicol Appl Pharmacol 2005 ; 208: 178-185.
20. Matsushita T. Arimatsu Y. Nomura S.. Experimental study on contact dermatitis caused by dithiocarbamates maneb, Mancozeb, zineb, and their related compounds. Int Arch Occup Environ Health 1976 ; 37: 169-178.
21. Kleibl K. Rackova M.. Cutaneous allergic reaction to dithiocarbamates. Contact Dermat 1980 ; 6: 348-349.
22. Bruze M. Fregert S.. Allergic contact dermatitis from ehtylene thiourea. Contact Dermat 1983 ; 9: 208-212.
23. Higo A. Ohtake N. Saruwatari K. Kanzaki T.. Photoallergic contact dermatitis from Mancozeb, an agricoltural fungicide. Contact Dermat 1996 ; 35: 183.
24. Iliev D. Elsner P.. Allergic contact dermatitis from the fungicide Rondo-M and the insecticide Alfacron. Contact Dermat 1997 ; 36: 51.
25. Colosio C. Birindelli S. Corsini E. Galli CL. Maroni M.. Low level exposure to chemicals and immune system. Toxicol Appl Pharmacol 2005 ; 207 (Suppl.): 320-328.
26. Fustinoni S. Campo L. Colosio C. Birindelli S. Foà V.. Application of gas chromatographic/mass spectrometry for the determination of urinary ethylenethiourea in humans. J Chromatography B 2005 ; 814: 251-258.
27. Van Loveren H. Germolec D. Koren HS. Luster MI. Nolan C. Repetto R.. Report of the Bilthoven symposium: Advancement of epidemiological studies in assessing the human health effects of immunotoxic agents in the environment and the workplace. Biomarkers 1999 ; 4: 135-157.
28. Aprea C. Betta A. Catenacci G. Lotti A. Minoia C. Passini W.. Reference values of urinary ethylenethiourea in four regions of Italy (multicentric study). Sci Total Environ 1996 ; 192: 83-93.
29. Aprea C. Betta A. Catenacci G. Colli A. Lotti A. Minoia C.. Urinary excretion of ethylenethiourea in five volunteers on a controlled diet (multicentric study). Sci Total Environ 1997 ; 203: 167-179.
30. Aprea C. Sciarra G. Sartotelli P. Mancini R. Di Luca V.. Environmental and biological monotoring of exposure to mancozeb, ETU and dimethoate during industrial formulation. J Toxicol Environ Health 1998 ; 53: 263-281.
31. Pennanen S;.Makkonen S;.Jyrki Liesivuori J;.. Effects of occupational exposure to pesticides on immunologicalparameters among potato farmers in Finland. Hum Exp Toxicol.
32. Swaen GMH;.Amelsvoort LGPM;.van Boers D;.Corsini E;.Fustinoni S;.Vergieva T;.. Occupational exposure to ethylenebisdithiocarbamates in agriculture and allergy. Results from the EUROPIT field study. Hum Exp Toxicol.