Possible dual roles for prostacyclin in human pregnancy and labor

Journal of Clinical Investigation

Volumn 118, Issue 12, 2008, Pages 3829-3832

  Taggart, Michael J ^a   Europe Finner, G Nicholas ^a   Mitchell, Bryan F ^b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; PROSTACYCLIN;

HUMAN; LABOR; MYOMETRIUM; NOTE; PREGNANCY; PREMATURE LABOR; PRIORITY JOURNAL; PROSTAGLANDIN METABOLISM; SMOOTH MUSCLE CONTRACTILITY; TRANSLATION REGULATION; UTERUS CONTRACTILITY;

ADULT; CONNEXIN 43; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLOOXYGENASE 2; EPOPROSTENOL; FEMALE; GAP JUNCTIONS; HUMANS; MYOMETRIUM; OXYTOCICS; OXYTOCIN; PARTURITION; PREGNANCY; RECEPTORS, EPOPROSTENOL; SIGNAL TRANSDUCTION; UP-REGULATION; UTERINE CONTRACTION;

EID: 57449089209     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI37785     Document Type: Note

References (23)

1. Price, S.A., Pochun, I., Phaneuf, S., and López Bernal, A. 2000. Adenylyl cyclase isoforms in pregnant and non-pregnant human myometrium. J. Endocrinol. 164:21-30.
2. Blank, V., Hirsch, E., Challis, J.R.G., Romero, R., and Lye, S.J. 2008. Cytokine signaling, inflammation, innate immunity and preterm labour - a workshop report. Placenta. 29(Suppl A):S102-S104.
3. Lindström, T., and Bennett, P.R. 2005. The role of nuclea factor kappa B in human labour. Reproduction. 130:569-581.
4. Fetalvero, K.M., et al. 2008. Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturition. J. Clin. Invest. 118:3966-3979.
5. Bailey, J., Tyson-Capper, A.J., Gilmore, K., Robson, S.C., and Europe-Finner, G.N. 2005. Identification of human myometrial target genes of the cAMP pathway: the role of cAMP-response element binding (CREB) and modulator (CREMalpha and CREM-tau2alpha) proteins. J. Mol. Endocrinol. 34:1-17.
6. Sooranna, S.R., Grigsby, P., Myatt, L., Bennett, P.R., and Johnson, M.R. 2005. Prostanoid receptors in human uterine myocytes: the effect of reproductive state and stretch. Mol. Human Reprod. 12:859-864.
7. Marston, S. 1989. Calcium ion-dependent regulation of uterine smooth muscle thin filaments by caldesmon. Am. J. Obstet. Gynecol. 160:252-257.
8. Small, J.V., and Gimona, M. 1998. The cytoskeleton of the vertebrate smooth muscle cell. Acta. Physiol. Scand. 164:341-348.
9. Bailey, J., et al. 2002. Characterisation and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2) isoforms in the human myometrium during pregnancy and labor: identification of a novel ATF2 species with potent transactivation properties. J. Clin. Endocrinol. Metabol. 87:1717-1728.
10. Europe-Finner, G.N., Phaneuf, S., Tolkovsky, A.M., Watdon, S.P., and Lopez Bernal, A. 1994. Down regulation of Galphas in human myometrium in term and preterm labour: a mechanism for parturition. J. Clin. Endocrinol. Metabol. 79:1835-1839.
11. Goldenberg, R.L., Culhane, J., Iams, J.D., and Romero, R. 2008. Epidemiology and causes of preterm birth. Lancet. 371:75-84.
12. Murray, C.J., and Lopez, A.D. 1997. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet. 349:1436-1442.
13. Macones, G.A., Berlin, M., and Berlin, J.A. 1995. Efficacy of oral beta-agonist maintenance therapy in preterm labor: a meta-analysis. Obstet. Gynecol. 85:313-317.
14. [No authors listed.] 2007. Spatiotemporal mechanisms of life [editorial]. Nat. Chem. Biol. 3:593.
15. Buonomano, D.V. 2007. The biology of time across different scales. Nat. Chem. Biol. 3:594-597.
16. 2+: molecular determinants and functional consequences. Physiol. Rev. 86:369-408.
17. Sillitoe, K., Horton, C., Spiller, D.G., and White, M.R. 2007. Single-cell time-lapse imaging of the dynamic control of NF-kappaB signalling. Biochem. Soc. Trans. 35:263-366.
18. Jarnæss, E., and Taskén, K. 2007. Spatiotemporal control of cAMP signalling processes by anchored signalling complexes. Biochem. Soc. Trans. 35:931-937.
19. Ku, C.Y., Word, R.A., and Sanborn, B.M. 2005. Differential expression of protein kinase A, AKAP79, and PP2B in pregnant human myometrial membranes prior to and during labor. J. Soc. Gynecol. Investig. 12:421-427.
20. MacDougall, M.W., Europe-Finner, G.N., and Robson, S.C. 2003. Human myometrial quiescence and activation during gestation and parturition involve dramatic changes in expression and activity of particulate type II (RII alpha) protein kinase A holoenzyme. J. Clin. Endocrinol. Metab. 88:2194-2205.
21. Yuan, W., and Lopwz Bernal, A. 2007. Cyclic AMP signalling pathways in the regulation of uterine relaxation. BMC Pregnancy and Childbirth. 7:S10.
22. Misra, U.K., and Pizzo, S.V. 2005. Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. J. Biol. Chem. 280:38276-38289.
23. Noble, D. 2006. The music of life: biology beyond the genome. Oxford University Press. Oxford, United Kingdom. 153 pp.