Severe hemolytic anemia and fatal hepatic failure associated with nimesulide

Digestive and Liver Disease

Volumn 41, Issue 1, 2009, Pages 80-

  Betrosian, A P ^a   Flevari, K ^a   Andrianakis, I ^a   Boudouri, I ^a   Douzinas, E E ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CREATININE; GLUCOSE; HAPTOGLOBIN; HEMOGLOBIN; LACTATE DEHYDROGENASE; LACTULOSE; MANNITOL; METHYLPREDNISOLONE; NIMESULIDE; NITROGEN; UREA; VITAMIN K GROUP;

ADULT; ANAMNESIS; BRAIN EDEMA; CASE REPORT; CHRONIC LIVER DISEASE; COMA; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG WITHDRAWAL; EOSINOPHIL; FEMALE; HEMOLYTIC ANEMIA; HOSPITAL ADMISSION; HUMAN; LETTER; LIVER FAILURE; LYMPHOCYTE; NEUTROPHIL; PHYSICAL EXAMINATION; PROTHROMBIN TIME; TOOTH PAIN; TOOTH PROSTHESIS; UREA NITROGEN BLOOD LEVEL;

ANEMIA, HEMOLYTIC; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; FATAL OUTCOME; FEMALE; HUMANS; LIVER FAILURE, ACUTE; MIDDLE AGED; NURSES; SULFONAMIDES;

EID: 57449087667     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2008.06.013     Document Type: Letter

References (5)

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2. Boelsterrli U.A. Mechanism of NSAID-induced hepatotoxicity: focus on nimesulide. Drug Saf 25 (2002) 633-648
3. Schattner A., Sokolovskaya N., and Cohen J. Fatal hepatitis and renal failure during treatment with nimesulide. J Intern Med 247 (2000) 153-155
4. Rodrigo L., de Francisco R., Perez-Pariente J.M., Cahadia V., Tojo R., Rodriguez M., et al. Nimesulide-induced severe haemolytic anemia and acute liver failure leading to liver transplantation. Scand J Gastroenterol 37 (2002) 1341-1343
5. Dastis S.N., Rahier J., Lerut J., and Geubel A.P. Liver transplantation for nonsteroidal anti-inflammatory drug-induced liver failure: nimesulide as the first implicated compound. Eur J Gastroenterol Hepatol 19 (2007) 919-922