Different elimination patterns of β-trace protein, β2-microglobulin and cystatin C in haemodialysis, haemodiafiltration and haemofiltration

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 68, Issue 8, 2008, Pages 685-691

  Lindström, Veronica ^a   Grubb, Anders ^a   Alquist Hegbrant, Maria ^b   Christensson, Anders ^c,d  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b Medical and Safety Office   (Sweden)

^c Malmö University Hospital   (Sweden)

^d LUND UNIVERSITY   (Sweden)

Author keywords

Beta 2 microglobulin; Cystatins; Dialysis; Haemofiltration; Kidney artificial

Indexed keywords

BETA 2 MICROGLOBULIN; CREATININE; CYSTATIN C; PROTEIN BETA TRACE; UNCLASSIFIED DRUG; UREA; UREMIC TOXIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEMODIAFILTRATION; HEMODIALYSIS; HEMOFILTRATION; HUMAN; MALE; MOLECULAR WEIGHT; PLASMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; ULTRAFILTRATION;

ADULT; AGED; AGED, 80 AND OVER; BETA 2-MICROGLOBULIN; CYSTATIN C; FEMALE; HEMODIAFILTRATION; HEMOFILTRATION; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LIPOCALINS; MALE; MIDDLE AGED; TIME FACTORS;

EID: 57349198062     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510802047693     Document Type: Article

References (23)

1. Held PJ, Port FK, Wolfe RA, Stannard DC, Carroll CE, Daugirdas JT, et al. The dose of hemodialysis and patient mortality. Kidney Int 1996;50:550-6.
2. Eknoyan G, Beck GJ, Cheung AK, Daugirdas JT, Greene T, Kusek JW, et al. Hemodialysis (HEMO) Study Group. Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med 2002;347:2010-19.
3. Vanholder R, De Smet R, Glorieux G, Argiles A, Baurmeister U, Brunet P, et al. European Uremic Toxin Work Group (EUTox). Review on uremic toxins: classification, concentration and interindividual variability. Kidney Int 2003;63:1934-43.
4. Leypoldt JK, Cheung A, Carroll C, Stannard D, Pereira B, Agodoa L, et al. Effect of dialysis membranes and middle molecule removal on chronic hemodialysis patient survival. Am J Kidney Dis 1999;33:349-55.
5. Kabanda A, Jadoul M, Pochet JM, Lauwerys R, van Ypersele de Strihou C, et al. Determinants of the serum concentrations of low molecular weight proteins in patients on maintenance hemodialysis. Kidney Int 1994;45:1689-96.
6. Chelamcharla M, Leypoldt J, Cheung A. Dialyzer membranes as determinants of the adequacy of dialysis. Semin Nephrol 2005;25:81-9.
7. Shirahama T, Skinner M, Cohen AS, Gejyo F, Arakawa M, Suzuki M, et al. Histochemical and immunohistochemical characterization of amyloid associated with chronic hemodialysis as beta 2-microglobulin. Lab Invest 1985;53:705-9.
8. Campo A, Lanfranco G, Gramaglia L, Goia F, Cottino R, Giusto V. Could plasma cystatin C be useful as a marker of hemodialysis low molecular weight proteins removal? Nephron Clin Pract 2004;98:79-82.
9. Thysell H, Grubb A, Lindholm T, Ljunggren L, Martensson L. Cystatin C: a new marker of biocompatibility or a good marker for the redistribution of LMW proteins during hemodialysis? ASAIO Trans 1988;34:202-4.
10. Olsson JE, Link H. Distribution of serum proteins and beta-trace protein within the nervous system. J Neurochem 1973;20:837-46.
11. Hoffmann A, Nimtz M, Wurster U, Conradt H. Carbohydrate structures of beta-trace protein from human cerebrospinal fluid: evidence for "brain-type" N-glycosylation. J Neurochem 1994;63:2185-96.
12. Hoffmann A, Nimtz M, Conradt H. Molecular characterization of beta-trace protein in human serum and urine: a potential diagnostic marker for renal diseases. Glycobiology 1997;7:499-506.
13. Priem F, Althaus H, Birnbaum M, Sinha P. Conradt H, Jung K. Beta-trace protein in serum: a new marker of glomerular filtration rate in the creatinine-blind range. Clin Chem 1999;45:567-8.
14. Kyhse-Andersen J, Schmidt C, Nordin G, Andersson B, Nilsson-Ehle P, Lindström V, et al. Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric metod, is a better marker than serum creatinine for glomerular filtration rate. Clin Chem 1994;40:1921-6.
15. Norlund L, Fex G, Lanke J, von Schenk H, Nilsson JE, Leksell H, et al. Reference intervals of the glomerular filtration rate and cell-proliferation markers: serum cystatin C and serum beta 2-microglobulin/cystatin C-ratio. Scand J Clin Lab Invest 1997;57:463-70.
16. Dati F, Schumann G, Thomas L, Aguzzi F, Baudner S, Bienvenu J, et al. Consensus of a group pf professional societies and diagnostic companies on guidelines for interim reference ranges for 14 proteins in serum based on the standarization against the IFCC/BOR/CAP reference material (CRM 470). Eur J Clin Chem Clin Biochem 1996;34:517-20.
17. Canaud B, Bragg-Gresham JL, Marshall MR, Desmeules S, Gillespie BW, Depner T, et al. Mortality risk for patients receiving hemodiafiltration versus hemodialysis: European results from the DOPPS. Kidney Int 2006;69:2087-93.
18. Altieri P, Sorba G, Bolasco P, Asproni E, Ledebo I, Cossu M, et al. Second Sardinian Multicentre Study. Predilution haemofiltration - the Second Sardinian Multicentre Study: comparisons between haemofiltration and haemodialysis during identical Kt/V and session times in a long-term crossover study. Nephrol Dial Transplant 2001;16:1207-13.
19. Cheung AK, Rocco MV, Yan G, Leypoldt JK, Levin NW, Greene T, et al. Serum beta-2 microglobulin levels predict mortality in dialysis patients: results of the HEMO Study. J Am Soc Nephrol 2006;17:546-55.
20. Cheung AK, Levin NW, Greene T, Agodoa L, Bailey J, Beck G, et al. Effects of high-flux hemodialysis on clinical outcomes: results of the HEMO study. J Am Soc Nephrol 2003;14:3251-63.
21. Melegos DN, Grass L, Pierratos A, Diamandis EP. Highly elevated levels of prostaglandin D synthase in the serum of patients with renal failure. Urology 1999;53:32-7.
22. Kerr P, Argiles A, Flavier J, Canaud B, Mion C. Comparison of hemodialysis and hemodiafiltration: a long-term longitudinal study. Kidney Int 1992;41:1035-40.
23. Maduell F, Navarro V, Cruz MC, Torregrosa E, Garcia D, Simon V, et al. Osteocalcin and myoglobin removal in on-line hemodiafiltration versus low- and high-flux hemodialysis. Am J Kidney Dis 2002;40:582-9.