6-Thioguanine in children with acute lymphoblastic leukaemia: Influence of food on parent drug pharmacokinetics and 6-thioguanine nucleotide concentrations

British Journal of Clinical Pharmacology

Volumn 51, Issue 6, 2001, Pages 531-539

  Lancaster, D L ^a   Patel, N ^b   Lennard, L ^c   Lilleyman, J S ^c  

^a ROYAL LONDON HOSPITAL   (United Kingdom)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

6 thioguanine; 6 thioguanine nucleotides; Childhood lymphoblastic leukaemia; Food; Pharmacokinetics

Indexed keywords

CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; DRUG METABOLITE; ETOPOSIDE; METHOTREXATE; PREDNISOLONE; STEROID; TIOGUANINE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; AREA UNDER THE CURVE; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET RESTRICTION; DOSE TIME EFFECT RELATION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; ERYTHROCYTE; FEEDING; FOOD; HUMAN; PRIORITY JOURNAL; REDUCTION; SAMPLING; STEADY STATE;

ADMINISTRATION, ORAL; ADOLESCENT; AREA UNDER CURVE; CHILD; CHILD, PRESCHOOL; CROSS-OVER STUDIES; FASTING; FOOD; FOOD-DRUG INTERACTIONS; GUANINE NUCLEOTIDES; HALF-LIFE; HUMANS; INFANT; LEUKEMIA, LYMPHOCYTIC, ACUTE; THIOGUANINE; TIME FACTORS; VARIATION (GENETICS);

EID: 0034819143     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0306-5251.2001.01391.x     Document Type: Article

References (29)

1. Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered?
2. Oral 6-mercaptopurine in childhood leukemia: Parent drug pharmacokinetics and active metabolite concentrations
3. The effect of methotrexate on the bioavailability of oral 6-mercaptopurine
4. Dose-dependent kinetics of orally administered 6-mercaptopurine in children with leukemia
5. The effect of food on the oral administration of 6-mercaptopurine
6. Influence of food intake on bioavailability of oral 6-mercaptopurine in children with acute lymphoblastic leukemia
7. Variability of 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute leukemia
8. Oral mercaptopurine in childhood leukemia: Influence of food intake on bioavailability
9. Delayed cytotoxicity of 6-mercaptopurine is compatible with mitotic death caused by DNA damage due to incorporation of 6-thioguanine into DNA as 6-thioguanine nucleotide
10. Purine substrates for human thiopurine methyltransferase
11. Human liver thiopurine methyltransferase pharmacogenetics: Biochemical properties, liver-erythrocyte correlation and presence of isoenzymes
12. High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: Quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample
13. Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia
14. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
15. Intracellular metabolites of mercaptopurine in children with lymphoblastic leukaemia: A possible indicator of non-compliance?
16. Pharmacology of 6-thioguanine in man
17. On the cellular pharmacokinetics of 6-thioguanine in acute myelogenous leukemia
18. Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia?
19. Pharmacokinetics and metabolism of thiopurines in children with acute leukaemia receiving 6-thioguanine versus 6-mercaptopurine
20. Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red blood cells
21. Clinical pharmacology of oral thioguanine in acute myelogenous leukemia
22. Can food influence the absorption of methotrexate in children with acute lymphoblastic leukaemia?
23. Milk could decrease the bioavailability of 6-mercaptopurine
24. 6-Mercaptopurine plasma levels in children with acute lymphoblastic leukemia: Relation to relapse risk and myelotoxicity
25. Pharmacokinetics of oral 6-mercaptopurine: Relationship between plasma levels and urine excretion of parent drug
26. Intraindividual variation in 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute lymphoblastic leukaemia
27. Thiopurine methyltransferase deficiency in childhood lymphoblastic leukaemia: 6-Mercaptopurine dosage strategies
28. Maintenance chemotherapy for childhood acute lymphoblastic leukaemia: Better in the evening
29. Circadian time-dependent response of childhood lymphoblastic leukemia to chemotherapy: A long-term follow-up study of survival