Genetic risk factors of ischemic stroke identified by a genome-wide association study

Brain and Nerve

Volumn 60, Issue 11, 2008, Pages 1339-1346

  Kubo, Michiaki ^a  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

AGTRL 1; Genetic risk factor; Genome wide association study; PRKCH; Prospective cohort study

Indexed keywords

PROTEIN KINASE C ETA;

ARTICLE; ATHEROSCLEROSIS; CEREBROVASCULAR ACCIDENT; GENE IDENTIFICATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; JAPANESE; NUCLEOTIDE SEQUENCE; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM;

COHORT STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENOME, HUMAN; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN KINASE C; RECEPTORS, G-PROTEIN-COUPLED; RISK FACTORS; STROKE;

EID: 57349184325     PISSN: 18816096     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Kubo M, Kiyohara Y, Kato I, Tanizaki Y, Arima H, et al: Trends in the incidence, mortality, and survival rate of cardiovascular disease in a Japanese community: the Hisayama study. Stroke 34: 2349-2354, 2003
2. Kubo M, Kiyohara Y, Ninomiya T, Tanizaki Y, Yonemoto K, et al: Decreasing incidence of lacunar vs. other types of cerebral infarction in a Japanese population. Neurology 66: 1539-1544, 2006
3. Floßmann E, Schulz UGR, Rothwell PM: Systematic review of methods and results of studies of the genetic epidemiology of ischemic stroke. Stroke 35: 212-227, 2004
4. The International Hapmap Consortium: A haplotype map of the human genome. Nature 437: 1299 1320, 2005
5. Ozaki K, Ohnishi Y, Iida A, Sekine A, Yamada R, et al: Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction. Nat Genet 32: 650-654, 2002
6. The Wellcome Trust Case Control Consortium: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678, 2007
7. Gretarsdottir S, Sveinbjörnsdottir S, Jonsson HH, Jakobsson F, et al: Localization of a susceptibility gene for common forms of stroke to 5q12. Am J Hum Genet 70: 593-603, 2002
8. Gretarsdottir S, Thorleifsson G, Reynisdottir ST, Manolescu A, Jonsdottir S, et al: The gene encoding phosphosdiesterase 4D confers risk of ischemic stroke. Nat Genet 35: 131-138, 2003
9. Helgadottir A, Manolescu A, Thorleifsson G, Gretars-dottir S, Jonsdottir H, et al: The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet 36: 233-239, 2004
10. Helgadottir A, Gretarsdottir S, St Clair D, Manolescu A, Cheung J, et al: Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population. Am J Hum Genet 76: 505-509, 2005
11. Japanese source
12. Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, et al: A nonsynonymous SNP in PRKCH (protein kinase C η) increases the risk of cerebral infarction. Nat Genet 39: 212-217, 2007
13. Takata Y, Hamada D, Miyatake K, Nakano S, Shinomiya F, et al: Genetic association between the PRKCH gene encoding protein kinase C η isozyme and rheumatoid arthritis in the Japanese population. Arthritis Rheum 56: 30-42, 2007
14. Serizawa M, Nabika T, Ochiai Y, Takahashi K, Yamaguchi S, et al: Association between PRKCH gene polymorphisms and subcortical silent brain infarction. Atherosclerosis 199: 340-345, 2008
15. Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushita T, et al: Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction. Hum Mol Genet 16: 630-639, 2007
16. Hashimoto T, Kihara M, Imai N, Yoshida S, Shimoyamada H, et al: Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis. Am J Pathol 171: 1705-1712, 2007