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Volumn 38, Issue 24, 2008, Pages 4452-4459

New synthesis of simvastatin

Author keywords

3,4 Dihydro 2H pyran; Low density lipoprotein; Methylation; Simvastatin

Indexed keywords

3,4 DIHYDRO 2H PYRAN DERIVATIVE; HYDROXYL GROUP; LACTONE; LOW DENSITY LIPOPROTEIN; MEVINOLIN; PYRAN DERIVATIVE; SIMVASTATIN; UNCLASSIFIED DRUG;

EID: 57349175717     PISSN: 00397911     EISSN: 15322432     Source Type: Journal    
DOI: 10.1080/00397910802369570     Document Type: Article
Times cited : (3)

References (7)
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    • Synthesis of synvinolin: Extremely high conversion alkylation of an ester enolate
    • Askin, D.; Verhoeven, T. R.; Liu, T. M.-H.; Shinkai, I. Synthesis of synvinolin: Extremely high conversion alkylation of an ester enolate. J. Org. Chem. 1991, 56, 4929-4932.
    • (1991) J. Org. Chem , vol.56 , pp. 4929-4932
    • Askin, D.1    Verhoeven, T.R.2    Liu, T.M.-H.3    Shinkai, I.4
  • 2
    • 0025240977 scopus 로고
    • Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug
    • Vickers, S.; Duncan, C. A.; Chen, I.-W.; Rosegy, A.; Duggan, E. Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug. Drug Metab. Dispos. 1989, 51, 138-145.
    • (1989) Drug Metab. Dispos , vol.51 , pp. 138-145
    • Vickers, S.1    Duncan, C.A.2    Chen, I.-W.3    Rosegy, A.4    Duggan, E.5
  • 3
    • 0027404961 scopus 로고
    • Determination of lovastatin (mevinolin) and mevinolinic acid in fermentation liquids
    • (a) Kysika, R.; Kren, V. Determination of lovastatin (mevinolin) and mevinolinic acid in fermentation liquids. J. Chromatogr. 1993, 630, 415-417.
    • (1993) J. Chromatogr , vol.630 , pp. 415-417
    • Kysika, R.1    Kren, V.2
  • 4
    • 0021962589 scopus 로고
    • Biosynthesis of the hypocholesterolemic agent mevinolin by Aspergillus terreus: Determination of the origin of carbon, hydrogen, and oxygen atoms by carbon-13 NMR and mass spectrometry
    • (b) Moore, R. N.; Bigam, G.; Chan, J. K.; Hogg, A. M.; Thomas, T.; Verderas, J. C. Biosynthesis of the hypocholesterolemic agent mevinolin by Aspergillus terreus: Determination of the origin of carbon, hydrogen, and oxygen atoms by carbon-13 NMR and mass spectrometry. J. Am. Chem. Soc. 1985, 107, 3694-3701.
    • (1985) J. Am. Chem. Soc , vol.107 , pp. 3694-3701
    • Moore, R.N.1    Bigam, G.2    Chan, J.K.3    Hogg, A.M.4    Thomas, T.5    Verderas, J.C.6
  • 5
    • 0023038220 scopus 로고
    • The synthesis of mevinic acids
    • (c) Rosen, T.; Heathcock, C. H. The synthesis of mevinic acids. Tetrahedron 1986, 42, 4909-4951.
    • (1986) Tetrahedron , vol.42 , pp. 4909-4951
    • Rosen, T.1    Heathcock, C.H.2
  • 6
    • 0022486908 scopus 로고
    • 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, 4: Side-chain ester derivatives of mevinolin
    • Also see Ref. 1
    • Hoffman, W. F.; Alberts, A. W.; Anderson, P. S.; Chem, J. S.; Smith, R. L.; Willward, A. K. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, 4: Side-chain ester derivatives of mevinolin. J. Med. Chem. 1986, 29, 849-852. Also see Ref. 1.
    • (1986) J. Med. Chem , vol.29 , pp. 849-852
    • Hoffman, W.F.1    Alberts, A.W.2    Anderson, P.S.3    Chem, J.S.4    Smith, R.L.5    Willward, A.K.6
  • 7
    • 0033477045 scopus 로고    scopus 로고
    • A cost-efficient synthesis of simvastatin via high-conversion methylation of an alkoxide ester enolate
    • Thaper, R. K.; Kumar, Y.; Kumar, S. M. D.; Misra, S.; Khanna, J. M. A cost-efficient synthesis of simvastatin via high-conversion methylation of an alkoxide ester enolate. Org. Process Res. Dev. 1999, 3, 476-479.
    • (1999) Org. Process Res. Dev , vol.3 , pp. 476-479
    • Thaper, R.K.1    Kumar, Y.2    Kumar, S.M.D.3    Misra, S.4    Khanna, J.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.