A cost-efficient synthesis of simvastatin via high-conversion methylation of an alkoxide ester enolate

Organic Process Research and Development

Volumn 3, Issue 6, 1999, Pages 476-479

  Thaper, Rajesh K ^a   Kumar, Yatendra ^a   Kumar, S M Dileep ^a   Misra, Satyananda ^a   Khanna, Jag Mohan ^a  

^a RANBAXY RESEARCH LABORATORIES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033477045     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op990187i     Document Type: Article

References (6)

1. (a) Kysika, R.; Kren, V. J. Chromatogr. 1993, 630, 415-417.
2. (b) Drugs Future 1987, 12, 309.
3. (c) Moore, R. N.; Bigarn, G.; Chan, J. K.; Hogg, A. M.; Thomas, T.; Verderas, J. C. J. Am. Chem. Soc. 1985, 107, 3694-3701
4. (d) Rosen, T.; Heathcock, C. H. Tetrahedron 1986, 42, 4909-4951.
5. Askin, D.; Verhoeven, T. R.; Liu, T.M-H; Shinkai, I. J. Org. Chem. 1991, 56, 4929-4932.
6. Hoffman, W. F.; Alberts, A. W.; Andersen, P. S.; Chem, J. S.; Smith, R. L.; Willward, A. K. J. Org. Chem. 1986, 29, 849-852. Also see ref 2.