Androgens in relationship to cardiovascular risk factors in the menopausal transition

Climacteric

Volumn 11, Issue 6, 2008, Pages 509-517

  Mesch, V R ^a   Siseles, N O ^b   Maidana, P N ^a   Boero, L E ^a   Sayegh, F ^b   Prada, M ^b   Royer, M ^b   Schreier, L ^a   Benencia, H J ^a   Berg, G A ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b HOSPITAL DE CLÍNICAS JOSÉ DE SAN MARTÍN   (Argentina)

Author keywords

Abdominal obesity; Androgens; Insulin resistance; Lipoproteins; Menopausal transition

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; ESTRADIOL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PRASTERONE SULFATE; TESTOSTERONE;

ADULT; AMENORRHEA; ANDROSTENEDIONE BLOOD LEVEL; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLIMACTERIUM; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPOPROTEIN BLOOD LEVEL; OUTCOME ASSESSMENT; POSTMENOPAUSE; PRIORITY JOURNAL; RISK FACTOR; TESTOSTERONE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

ABDOMINAL FAT; ADULT; AGE FACTORS; AGED; ANDROGENS; ANDROSTENEDIONE; ARGENTINA; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CHOLESTEROL, HDL; DEHYDROEPIANDROSTERONE SULFATE; ESTRADIOL; FEMALE; HUMANS; INSULIN RESISTANCE; LIPOPROTEINS; MENOPAUSE; MIDDLE AGED; RISK FACTORS; TRIGLYCERIDES;

EID: 57349165399     PISSN: 13697137     EISSN: 14730804     Source Type: Journal    
DOI: 10.1080/13697130802416640     Document Type: Article

References (33)

1. Burger HG, Dudley E, Cui J, Dennerstein L, Hopper JL. A prospective longitudinal study of serum testosterone, dehidroepiandrosterone sulfate and sex hormone-binding globulin levels through the menopause transition. J Clin Endocrinol Metab 2000;85:2832-8
2. Rannevik G, Jeppsson S, Johnell O, Bjerre B, Laurell-Borulf Y, Svanberg L. A longitudinal study of the perimenopausal transition: altered profiles of steroids and pituitary hormones, SHBG and bone mineral density. Maturitas 1995;21:103-13
3. Mushayandebvu T, Castracane VD, Gimpel T, Adel T, Santoro N. Evidence for diminished midcycle ovarian androgen production in older reproductive aged women. Fertil Steril 1996;65:721-3
4. Davison SL, Bell R, Donath S, Montalto JG, Davis SR. Androgen levels in adult females: changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab 2005;90:3847-53
5. Lasley BL, Santoro N, Randolf JF, et al. The relationship of circulating dehydroepiandrosterone, testosterone and estradiol to stages of the menopausal transition and ethnicity. J Clin Endocrinol Metab 2002;87:3760-7
6. Kalish G, Barrett-Connor E, Laughlin G, Gulanski BI. Association of endogenous sex hormones and insulin resistance among postmenopausal women: results from the Postmenopausal Estrogen/Progestin Intervention Trial. J Clin Endocrinol Metab 2003;88:1646-52
7. Lee CC, Kasa-Vubu JZ, Supiano MA. Androgenicity and obesity are independently associated with insulin sensitivity in postmenopausal women. Metabolism 2004;53:507-12
8. Tchernof A, Toth MJ, Poehlman ET. Sex hormone-binding globulin levels in middle-aged premenopausal women. Associations with visceral obesity and metabolic profile. Diabetes Care 1999;22:1875-81
9. Kahn SE, Prigeon RL, Schwartz RS, et al. Obesity, body fat distribution, insulin sensitivity and islet beta-cell function as explanations for metabolic diversity. J Nutr 2001;131:354-60S
10. Berg G, Mesch V, Boero L, et al. Lipid and lipoprotein profile in menopausal transition. Effects of hormones, age and fat distribution. Horm Metab Res 2004;36:215-20
11. Mesch VR, Boero LE, Siseles NO, et al. Metabolic syndrome throughout the menopausal transition: influence of age and menopausal status. Climacteric 2006;9:40-8
12. Haffner SM, Valdez RA. Endogenous sex hormones: impact on lipids, lipoproteins and insulin. Am J Med 1995;98:40-7S
13. Pugeat M, Moulin P, Cousin P, et al. Interrelations between sex hormone-binding globulin (SHBG), plasma lipoproteins and cardiovascular risk. J Steroid Biochem Mol Biol 1995;53:567-72
14. Reinecke H, Bogdanski J, Woltering A, et al. Relation of serum levels of sex hormone binding globulin to coronary heart disease in postmenopausal women. Am J Cardiol 2002;90:364-8
15. Rexrode KM, Manson JE, Lee I, et al. Sex hormone levels and risk of cardiovascular events in postmenopausal women. Circulation 2003;108:1688-93
16. Assmann G, Jabs H, Kohnert U, Nolte W, Schriewer H. LDL-cholesterol determination in blood serum following precipitation of LDL with polyvinylsulphate. Clin Chim Acta 1984;140:77-83
17. 2+ precipitation for quantitation of high-density-lipoprotein cholesterol. Clin Chem 1982;28:1379-88
18. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-19
19. Katz A, Nambi SS, Mather K, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000;85:2402-10
20. McAuley KA, Williams SM, Mann JI, et al. Diagnosing insulin resistance in the general population. Diabetes Care 2001;24:460-4
21. McLaughlin T, Abbasi F, Cheal K, Chu J, Lamendola C, Reaven G. Use of metabolic markers to identify overweight individuals who are insulin resistant. Ann Intern Med 2003;139:802-9
22. Rinaudo P, Strauss JF 3rd. Endocrine function of the postmenopausal ovary. Endocrinol Metab Clin N Am 2004;33:661-74
23. Celec P, Starka L. Dehydroepiandrosterone - is the fountain of youth drying out? Physiol Res 2003;52:397-407
24. Tannenbaum C, Barrett-Connor E, Laughlin GA, Platt RW. A longitudinal study of dehydroepiandrosterone sulphate (DHEAS) change in older men and women: the Rancho Bernardo Study. Eur J Endocrinol 2004;151:717-25
25. Burger H, Dudley E, Robertson D, Dennerstein L. Hormonal changes in the menopause transition. Recent Prog Horm Res 2002;57:257-75
26. Santoro N. The menopausal transition. Am J Med 2005;118(Suppl 12B):8-13
27. Mudali S, Dobs A, Ding J, Cauley J, Szklo M, Hill Golden S. Endogenous postmenopausal hormones and serum lipids: the Atherosclerosis Risk in Communities Study. J Clin Endocrinol Metab 2005;90:1202-9
28. Bell RJ, Davison SL, Papalia MA, McKenzie DP, Davis SR. Endogenous androgen levels and cardiovascular risk profile in women across the adult life span. Menopause 2007;14:630-8
29. Rosner W, Hryb DJ, Khan MS, Nakhla AM, Romas NA. Androgen and estrogen signaling at the cell membrane via G-proteins and cyclic adenosine monophosphate. Steroids 1999;64:100-6
30. Kahn SM, Hryb DJ, Nakhla AM, Romas NA, Rosner W. Sex hormone-binding globulin is synthesized in target cells. J Endocrinol 2002;175:113-20
31. Sutton-Tyrrell K, Wildman R, Matthews K, et al. Sex-hormone binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the Study of Women Across the Nation (SWAN). Circulation 2005;111:1242-9
32. Joffe HV, Ridker PM, Manson JE, Cook NR, Buring JE, Rexrode KM. Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease. Ann Epidemiol 2006;16:105-12
33. Crandall C, Palla S, Reboussin B, et al. Crosssectional association between markers of inflammation and serum sex steroid levels in the postmenopausal estrogen/progestin interventions trial. J Womens Health (Larchmt) 2006;15:14-23