Repeated administration of fresh garlic increases memory retention in rats

Journal of Medicinal Food

Volumn 11, Issue 4, 2008, Pages 675-679

  Haider, Saida ^a   Naz, Nosheen ^a   Khaliq, Saima ^a   Perveen, Tahira ^a   Haleem, Darakhshan J ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

5 hydroxytryptamine (serotonin); Garlic (Allium sativum); Memory; Passive avoidance test

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; BRAIN PROTEIN; GARLIC EXTRACT; SEROTONIN; TRYPTOPHAN; WATER;

5 HYDROXYINDOLEACETIC ACID BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; COGNITION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG MECHANISM; ELECTRIC SHOCK; ELECTROCHEMICAL DETECTION; GARLIC; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMOGENATE; MALE; MEMORY; MEMORY CONSOLIDATION; NEUROCHEMISTRY; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; REPEATED DRUG DOSE; SEROTONIN BLOOD LEVEL; SEROTONIN BRAIN LEVEL; SEROTONIN METABOLISM; TRYPTOPHAN BRAIN LEVEL; WISTAR RAT;

5-HYDROXYTRYPTOPHAN; ANIMALS; AVOIDANCE LEARNING; BRAIN; GARLIC; HYDROXYINDOLEACETIC ACID; MEMORY; PHYTOTHERAPY; PLANT PREPARATIONS; RATS; RATS, WISTAR; TRYPTOPHAN;

ALLIUM SATIVUM; ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 57349163739     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2006.0229     Document Type: Article

References (27)

1. Kosuge Y, Koen Y, Ishige K, Minami K, Urasawa H, Saito H, Ito Y: S-Allyl-L-cysteine selectively protects cultured rat hippocampal neurons from amyloid beta-protein- and tunicamycininduced neuronal death. Neuroscience 2003;122:885-895.
2. Nishiyama N, Moriguchi T, Morihara N, Saito H: Ameliorative effect of S-allylcysteine, a major thioallyl constituent in aged garlic extract, on learning deficits in senescence-accelerated mice. J Nutr 2001;131(3 Suppl):1093S-1095S.
3. Silagy C, Niel A: A meta analysis of the effect of garlic on blood pressure. J Hypertens 1994;12:463-468.
4. Borek C: Antioxidant health effects of aged garlic extract. J Nutr 2001;131(3 Suppl):1010S-1015S.
5. Sheela CG, Kumud K, Augusti KT: Antidiabetic effect of onion and garlic sulfoxide aminoacid in rats. J Planta Med 1995;61:356-357.
6. Moriguchi T, Takashina K, Chu PJ, Saito H, Nishiyama N: Prolongation of life span and improved learning in the senescence accelerated mouse produced by aged garlic extract. Biol Pharm Bull 1994;17:1589-1594.
7. Fillion G: Designer Foods III: Phytochemical in Garlic, Soy and Licorice: Research Update and Implications [transcript]. Georgetown University Conference Center, Washington, DC, 1994.
8. Haider S, Khaliq S, Ahmed SP, Perveen T, Haleem DJ: Long-term tryptophan administration enhances cognitive performance and increases 5-HT metabolism in the hippocampus of female rats. Amino Acids 2006;31:421-425.
9. Khaliq S, Haider S, Ahmed SP, Perveen T, Haleem DJ: Relationship of brain tryptophan and serotonin in improving cognitive performance in rats. Pak J Pharmaceut Sci 2006;19:11-15.
10. Hughes JH, Gallagher P, Young AH: Effect of acute tryptophan depletion on cognitive function in euthymic bipolar patients. Eur Neuropsychopharmacol 2002;12:123-128.
11. Porter RJ, Lunn BS, O'Brien JT: Effects of acute tryptophan depletion on cognitive function in Alzheimer's disease and in the healthy elderly. Psychol Med 2003;33:41-49.
12. Lieben CK, Van Oorsouw K, Deutz NE, Blockland A: Acute tryptophan depletion induced by a gelatin based mixture impairs object memory but not effective behavior and spatial learning in rats. Behav Brain Res 2004;151:53-64.
13. Haider S, Shameem S, Ahmed SP, Perveen T, Haleem DJ: Repeated administration of lead decreases brain 5HT metabolism and produces memory deficits in rats. Cell Mol Biol 2005;10:669-676.
14. Haleem DJ, Kennett GA, Curzon G: Hippocampal 5HT syntheses is greater in females than in males and is more decreased by 5HT 1A agonist 8-OH-DPAT. J Neural Transm 1990;79:93-101.
15. Haleem DJ, Perveen T: Brain regional serotonin synthesis following adaptation to repeated restraint. Neuroreport 1994;5:1785-1788.
16. Curzon G, Fernando JCR: Effect of aminophyeline on TRP and other aromatic aminoacids in plasma, brain and other tissues and on brain 5HT metabolism. Br J Pharmacol 1976;58:533-545.
17. Knott PJ, Curzon G: Free tryptophan in plasma and brain tryptophan from metabolism. Nature 1972;239:452-453.
18. Chaouloff F, Kennett GA, Serrurrier B, Merino D, Curzon G: Aminoacid analysis demonstrates that increased plasma free tryptophan causes the increase of brain tryptophan during exercise in the rats. J Neurochem 1986;46:1647-1650.
19. Fernstrom JD: Role of precursor availability in control of monoamine biosynthesis in brain. Physiol Rev 1983;63:484-546.
20. Struder HK, Weicker H: Physiology and pathophysiology of the serotonergic system and the implications on mental and physical performances. Part II. Int J Sports Med 2001;22:482-497.
21. Struder HK, Weicker H: Physiology and pathophysiology of the serotonergic system and the implications on mental and physical performances. Part I. Int J Sports Med 2001;22:467-481.
22. Curzon G, Joseph MH, Knott PJ: Effect of immobilization and food deprivation on brain tryptophan metabolism. J Neurochem 1972;19:1967-1974.
23. Andoga GI: The mechanism of the hypolipidemic effect of garlic oil extract in rats fed on high sucrose and alcohol diets. Biochem Biophys Res Commun 1987;142:1046-1052.
24. Sodimu O, Joseph PK, Augusti KT: Certain biochemical effects of garlic oil on rats maintained on high fat-high cholesterol diet. Experientia 1984;40:78-80.
25. Curzon G: Influence of plasma tryptophan on brain 5HT synthesis and serotonergic activity. Adv Exp Med Biol 1981;133:207-219.
26. Aschroft GW, Eccleston D, Crawford TB: 5-Hydroxyindole metabolism in rat brain. A study of intermediate metabolism using the technique of TRP loading. I. Methods. J Neurochem 1965;12:483-492.
27. Moir ATB, Eccleston D: The effects of precursor loading in the cerebral metabolism of 5-hydroxy indoles. J Neurochem 1968;15:1093-1108.