Anti-dopaminergic effect of the methanolic extract of Morus alba L. leaves

Indian Journal of Pharmacology

Volumn 40, Issue 5 SUPPL., 2008, Pages 221-226

  Yadav, Adhikrao ^a   Nade, Vandana ^b  

^a Govt College of Pharmacy   (India)

^b Department of Pharmacology   (India)

Author keywords

Anti dopaminergic; Catalepsy; Morus alba L; Stereotypy; Vas deferens

Indexed keywords

AMPHETAMINE; DOPAMINE; HALOPERIDOL; METOCLOPRAMIDE; MORUS ALBA EXTRACT; PHENOBARBITAL; PLANT EXTRACT; UNCLASSIFIED DRUG; DOPAMINE RECEPTOR BLOCKING AGENT; METHANOL; MORUS ALBA L EXTRACT;

ACUTE TOXICITY; AGGRESSION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDOPAMINERGIC ACTIVITY; ARTICLE; CATALEPSY; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG POTENTIATION; FOOTSHOCK; MALE; MOUSE; MULBERRY; NONHUMAN; PLANT LEAF; RAT; RIGHTING REFLEX; SLEEP TIME; SMOOTH MUSCLE CONTRACTION; STEREOTYPY; VAS DEFERENS; ANIMAL MODEL; BEHAVIOR DISORDER; DOPAMINE RECEPTOR BLOCKING; FIGHTING; ISOLATED ORGAN; LATENT PERIOD; MORUS ALBA L; MUSCLE CONTRACTION; SLEEP;

EID: 57349155244     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.44154     Document Type: Article

References (31)

1. The Wealth of India, Dictionary of Indian Raw materials. Vol. 7. Council of Scientific and Industrial Research; 1952. p. 429-37.
2. Mhaskar KS, Latter EB, Caius JS. Kirtikar and Basu's Indian Medicinal Plants. Vol. 3. Sri Satguru Publications 2000. p. 3185.
3. Nadkarni AK. Indian Materia Medica. Vol. 1. Mumbai: Popular Prakashan; 1976. p. 1292-4.
4. Fukai T, Hano Y, Hirakura K, Nomura T, Uzawa J, Fukushima K. Structures of two natural hypotensive Diels-alder type adducts, mulberrofurans F and G, from the cultivated Mulberry tree. Chem Pharm Bull (Tokyo) 1985;33:3195-204.
5. Jin WY, Na MK, An RB, Lee HY, Bae KH, Kang SS. Antioxidant compounds from twig of Morus alba. Nat Prod Sci 2002;8:129-32.
6. Singab AN, El-Beshbishy HA, Yonekawa M, Nomura T, Fukai T. Hypoglycemic effect of Egyptian Morus alba root bark extract: Effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats. J Ethnopharmacol 2005;100:333-8.
7. Du J, He ZD, Jiang R, Ye W, Xu H, But PP. Antiviral flavonoids from the root bark of Morus alba L. Phytochemistry 2003;62:1235-8.
8. El-Beshbishy HA, Singab AN, Sinkkonen J, Pihlaja K. Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats. Life Sci 2006;78:2724-33.
9. Kang TH, Oh HR, Jung SM, Ryu JH, Park MW, Park YK, et al. Enhancement of neuroprotection of Mulberry leaves (Morus alba L.) prepared by the anaerobic treatment against ischemic damage. Biol Pharm Bull 2006;29:270-4.
10. Oh H, Ko EK, Jun JY, Oh MH, Park SU, Kang KH, et al. Hepatoprotective and radical scavenging activities of preflavonoids, Coumarin and stilbene from Morus alba. Planta Med 2002;68:932-40.
11. Cheyl L. Ethnomedicines used in Trinidad and Tobago for urinary problem and Diabetes mellitus. J Ethnobiol Ethnomedicine 2006;13:45-51.
12. Enkhmaa B, Shiwaku K, Katsube T, Kitajima K, Anuurad E, Yamasaki M, et al. Mulberry (Morus alba L.) leaves and their major flavonol Quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor deficient mice. J Nutr 2005;135:729-34.
13. Nomura T, Fukai T, Hano Y, Nemato K, Terada S, Kuramochi T. Constituents of cultivated Mulberry tree. Planta Medica 1983;47:151-6.
14. Kusano G, Orihara S, Tsukamato D, Shibano M, Coskun M, Guvenc A, et al. Five new nortropane alkaloids and six new amino acids from the fruit of Morus albs L. growing in Turkey. Chem Pharm Bull (Tokyo) 2002;50:185-92.
15. Chen C, Liu L, Huang H, Yang M, Wang C. Mulberry extract inhibits the development of atherosclerosis in cholesterol fed rabbits. Food Chem 2005;91:601-7.
16. Kokate CK. Practical Pharmacognosy. Vallabh Prakashan, Delhi, India; 1994. p. 104-11.
17. Trease GD, Evans WC. Pharmacognosy. Vol. 275. Harcourt Brace and Company; 1997. p. 343-571.
18. Ferre S, Guix T, Prat G, Jane F, Casas M. Is experimental catalepsy properly measured? Pharmacol Biochem Behav 1990;35:753-5.
19. Bhosale KB, Balsara JJ, Gonkar RK, Bhosale BB, Gupta SK. Dose dependent response of central dopaminergic system to Metoclopramide in mice. Indian J Exp Biol 1997;35:618-22.
20. Dolphin A, Jenner P, Marsden CD, Pycock C, Tarsy D. Pharmacological evidence for cerebral dopamine receptor blockade by metoclopramide in rodent. Psychopharmacol 1975;41:133-8.
21. Bhattacharya SK, Muruganandam AV, Vikas K. Status report on Neuropharmacology. Indian J Pharmacol 2000;32:119-33.
22. Kasture SB. A Handbook of Experiments in preclinical pharmacology. Vol. 1. Career Publications, Nashik, India; 2006. p. 43-110.
23. Ayoka AO, Akomolafe RO, Iwalewa EO, Akanmu MA, Ukponmwan OE. Sedative, anti-epileptic and antipsychotic effects of Spondis mombin L. (Anacardiaceae) in mice and rats. J Ethnopahrmacol 2006;103:166-75.
24. Freire CM, Marques MO, Costa M. Effects of seasonal variation on the central nervous system activity of Ocimum gratissimum L. essential oil. J Ethnopharmacol 2006;105:161-6.
25. Hellion-Ibarrola MC, Ibarrola DA, Montalbetti Y, Kennedy ML, Heinichen O, Campuzano M, et al. The anxiolytic-like effects of Aloysia polystachya (Griseb) Moldenke (Verbenaceae) in mice. J Ethnopharmacol 2006;105:400-8.
26. Goyal RK. Practical in Pharmacology. Vol 1. B. S. Shaha Prakashan, Ahemdabad, India; 2003. p. 51-2.
27. Herbert YM. Neuropharmacology: The fifth generation of progress. Am Coll Neuropharmacol 2002;1:819-22.
28. Costall B, Naylor RJ, Olley JE. Cataleptic and circling behavior after intracerebral injections of Neuroleptic, cholinergic and anticholinergic agents into the caudate putamen, glopus pallidus and substantia nigra of rat brain. Neuropharmacology 1972;11:645-63.
29. Valame SP, Gupata KC. Effect of clonidine on amphetamine-induced stereotype. Indian J Pharmacol 1981;13:203-4.
30. Jain NN, Ohal CC, Shroff RH, Somani RS, Kasture VS, Kasture SB. Clitoria ternatea and the CNS. Pharmacol Biochem Behav 2003;75:529-36.
31. Gonzalez-Trujana ME, Carrera D, Ventura-Martinez R, Cedillo-Portugal E, Navarrete A. Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice. J Ethnopharmacol 2006;106:129-35.