Osteogenic differentiation of human Bone Marrow Stromal Cells (hBMSC) by cyclic longitudinal mechanical strain and dexamethasone;Osteogene differenzierung von humanen stromalen zellen aus dem knochenmark (hBMSC) unter dem einfluss von zyklischem mechanischem dehnungsstress und dexamethason

Zeitschrift fur Orthopadie und Unfallchirurgie

Volumn 146, Issue 5, 2008, Pages 636-643

  Haasper, Carl ^a   Drescher, M ^a   Hesse, E ^a   Krettek, C ^a   Zeichen, J ^a   Jagodzinski, M ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Bone; Stem cells; Stimulation; Stress

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 3; DEXAMETHASONE; MESSENGER RNA; TENASCIN; TRANSCRIPTION FACTOR RUNX2;

ARTICLE; BONE DEVELOPMENT; BONE MARROW; CELL DIFFERENTIATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; STROMA CELL;

EID: 57349139434     PISSN: 1864-669     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1038578     Document Type: Article

References (22)

1. Schieker M, Mutschler W. [Bridging posttraumatic bony defects. Established and new methods]. Unfallchirurg 2006; 109: 715-732
2. Heary RF, Schlenk RP, Sacchieri TA, Barone D, Brotea C. Persistent iliac crest donor site pain: independent outcome assessment. Neurosurgery 2002; 50: 510-516
3. Schaefer DJ, Klemt C, Zhang XH, Stark GB. Tissue engineering with mesenchymal stem cells for cartilage and bone regeneration. Chirurg 2000; 71: 1001-1008
4. Lennon DP, Edmison JM, Caplan AI. Cultivation of rat marrow-derived mesenchymal stem cells in reduced oxygen tension: effects on in vitro and in vivo osteochondrogenesis. J Cell Physiol 2001; 187: 345-355
5. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-147
6. Byers RJ, Brown J, Brandwood C, Wood P, Staley W, Hainey L, Freemont AJ, Hoyland JA. Osteoblastic differentiation and mRNA analysis of STRO-1-positive human bone marrow stromal cells using primary in vitro culture and poly (A) PCR. J Pathol 1999; 187: 374-381
7. Carter DR, Beaupre GS, Giori NJ, Helms JA. Mechanobiology of skeletal regeneration. Clin Orthop Relat Res 1998; S41-S55
8. Jagodzinski M, Krettek C. Effect of mechanical stability on fracture healing - an update. Injury 2007; 38: S3-S10
9. Igarashi M, Kamiya N, Hasegawa M, Kasuya T, Takahashi T, Takagi M. Inductive effects of dexamethasone on the gene expression of Cbfa1, Osterix and bone matrix proteins during differentiation of cultured primary rat osteoblasts. J Mol Histol 2004; 35: 3-10
10. Bruder SP, Fink DJ, Caplan AI. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 1994; 56: 283-294
11. Zeichen J, van Griensven M, Bosch U. The proliferative response of isolated human tendon fibroblasts to cyclic biaxial mechanical strain. Am J Sports Med 2000; 28: 888-892
12. Ignatius A, Blessing H, Liedert A, Kaspar D, Kreja L, Friemert B, Claes L. Effekte mechanischer Reize auf humane osteoblastäre Zellen in einer dreidimensionalen Kollagen-Typ-I-Matrix. Orthopäde 2004; 33: 1386-1393
13. Altman GH, Horan RL, Martin I, Farhadi J, Stark PR, Volloch V, Richmond JC, Vunjak-Novakovic G, Kaplan DL. Cell differentiation by mechanical stress. FASEB J 2002; 16: 270-272
14. Henriksen Z, Hiken JF, Steinberg TH, Jorgensen NR. The predominant mechanism of intercellular calcium wave propagation changes during long-term culture of human osteoblast-like cells. Cell Calcium 2006; 39: 435-444
15. Ogston N, Harrison AJ, Cheung HF, Ashton BA, Hampson G. Dexamethasone and retinoic acid differentially regulate growth and differentiation in an immortalised human clonal bone marrow stromal cell line with osteoblastic characteristics. Steroids 2002; 67: 895-906
16. Yoshikawa T, Ohgushi H, Ichijima K, Takakura Y. Bone regeneration by grafting of cultured human bone. Tissue Eng 2004; 10: 688-698
17. Kaspar D, Seidl W, Neidlinger-Wilke C, Ignatius A, Claes L. Dynamic cell stretching increases human osteoblast proliferation and CICP synthesis but decreases osteocalcin synthesis and alkaline phosphatase activity. J Biomech 2000; 33: 45-51
18. Neidlinger-Wilke C, Grood ES, Wang JHC, Brand RA, Claes L. Cell alignment is induced by cyclic changes in cell length: studies of cells grown in cyclically stretched substrates. J Orthop Res 2001; 19: 286-293
19. Weyts FA, Bosmans B, Niesing R, van Leeuwen JP, Weinans H. Mechanical control of human osteoblast apoptosis and proliferation in relation to differentiation. Calcif Tissue Int 2003; 72: 505-512
20. Simmons CA, Matlis S, Thornton AJ, Chen S, Wang CY, Mooney DJ. Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech 2003; 36: 1087-1096
21. Banerjee C, Javed A, Choi JY, Green J, Rosen V, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Differential regulation of the two principal Runx2/Cbfa1n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype. Endocrinology 2001; 142: 4026-4039
22. Atmani H, Audrain C, Mercier L, Chappard D, Basle MF. Phenotypic effects of continuous or discontinuous treatment with dexamethasone and/or calcitriol on osteoblasts differentiated from rat bone marrow stromal cells. J Cell Biochem 2002; 85: 640-650