Methyl 1-imidazolecarbodithioate as a thiocarbonyl transfer reagent: a facile one-pot, three-component synthesis of novel 2-substituted-5-aryl-1-oxo-3-thioxo-1,2,3,5,11,11a-hexahydro-6H-imidazo- [1,5-b]-β-carbolines

Tetrahedron Letters

Volumn 50, Issue 3, 2009, Pages 366-369

  Singh, Balendu ^a   Sundaram, G S M ^a   Misra, Nimesh C ^a   Ila, Hiriyakkanavar ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY KANPUR   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1 OXO 3 THIOXO 1,2,3,5,11,11A HEXAHYDRO 6H IMIDAZO[1,5 B]BETA CARBOLINE; BETA CARBOLINE DERIVATIVE; CARBONYL DERIVATIVE; ESTER DERIVATIVE; METHYL 1 IMIDAZOLE CARBODITHIOATE; METHYL GROUP; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CYCLIZATION; ONE POT SYNTHESIS; REACTION ANALYSIS;

EID: 57349135651     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.11.008     Document Type: Article

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19. 6
20. All the methyl ester hydrochlorides 4a-d were prepared by treatment of the corresponding acids 3a-d with thionyl chloride in methanol at rt. The ester hydrochlorides 4a-d thus obtained were used as such in further reactions.
21. 6,7a
22. 3): δ 1.20-1.40 (m, 3H), 1.6 (br s, 5H), 2.20 (t, J = 11.48 Hz, 2H), 2.89 (dd, J = 14.64, 12.48 Hz, 1H), 3.46 (dd, J = 15.2, 5.8 Hz, 1H), 4.33 (dd, J = 10.76, 5.88 Hz, 1H), 4.55-4.61 (m, 1H), 5.61 (br s, 1H), 6.80 (s, 1H), 6.94 (d, J = 7.8 Hz, 2H), 7.00 (d, J = 7.8 Hz, 1H), 7.14-7.22 (m, 2H)
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