Sympathetic cholinergic nerve contributes to increased muscle blood flow at the onset of voluntary static exercise in conscious cats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 295, Issue 4, 2008, Pages

  Komine, Hidehiko ^a,b   Matsukawa, Kanji ^a   Tsuchimochi, Hirotsugu ^a   Nakamoto, Tomoko ^a   Murata, Jun ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Acetylcholine and nitric oxide; Autonomic blockade; Central command; Exercise hyperemia; Voluntary behavior

Indexed keywords

ATROPINE; HEXAMETHONIUM BROMIDE;

ANIMAL EXPERIMENT; ARTICLE; BRACHIAL ANGIOGRAPHY; CAROTID ARTERY; CAT; CHOLINERGIC NERVE; CONTROLLED STUDY; DRUG EFFECT; FORELIMB; JUGULAR VEIN; MUSCLE BLOOD FLOW; NONHUMAN; PRIORITY JOURNAL; STATIC EXERCISE; VASCULAR RESISTANCE;

ANIMALS; ATROPINE; BLOOD PRESSURE; BRACHIAL ARTERY; CATS; CHOLINERGIC FIBERS; CONSCIOUSNESS; EATING; ELECTRIC STIMULATION; GROOMING; HEART RATE; HEXAMETHONIUM; MOVEMENT; MUSCLE CONTRACTION; MUSCLE, SKELETAL; NG-NITROARGININE METHYL ESTER; PHYSICAL CONDITIONING, ANIMAL; REGIONAL BLOOD FLOW; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTION; VASODILATION;

EID: 57349118399     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00076.2008     Document Type: Article

References (48)

1. Abrahams VC, Hilton SM, Zbrozyna A. Active muscle vasodilation produced by stimulation of the brain stem: its significance in the defence reaction. J Physiol 154: 491-513, 1960.
2. Abrahams VC, Hilton SM, Zbrozyna AW. The role of active muscle vasodilation in the alerting stage of the defence reaction. J Physiol 171: 189-202, 1964.
3. Adams DB, Baccelli G, Mancia G, Zanchetti A. Cardiovascular changes during naturally elicited fighting behavior in the cat. Am J Physiol 216: 1226-1235, 1969.
4. Adams DB, Baccelli G, Mancia G, Zanchetti A. Relation of cardiovascular changes in fighting to emotion and exercise. J Physiol 212: 321-335, 1971.
5. Amundsen BH, Wisloff U, Helgerud J, Hoff J, Slordahl SA. Ultrasound recorded axillary artery blood flow during elbow-flexion exercise. Med Sci Sports Exerc 34: 1288-1293, 2002.
6. Arnold JMO, McDevitt DG. Contribution of the vagus to the haemodynamic responses following intravenous boluses of isoprenaline. Br J Clin Pharmacol 15: 423-429, 1983.
7. Barcroft H, Brod J, Hejl Z, Hirsjarvi EA, Kitchin AH. The mechanism of the vasodilatation in the forearm muscle during stress (mental arithmetic). Clin Sci 19: 577-586, 1960.
8. Blair DA, Glover WE, Greenfield ADM, Roddie IC. Excitation of cholinergic vasodilator nerves to human skeletal muscles during emotional stress. J Physiol 148: 633-647, 1959.
9. Bolme P, Fuxe K. Adrenergic and cholinergic nerve terminals in skeletal muscle vessels. Acta Physiol Scand 78: 52-59, 1970.
10. Brock RW, Tschakovsky ME, Shoemaker JK, Halliwill JR, Joyner MJ, Hughson RL. Effects of acetylcholine and nitric oxide on forearm blood flow at rest and after a single muscle contraction. J Appl Physiol 85: 2249-2254, 1998.
11. Buckwalter JB, Clifford PS. Autonomic control of skeletal muscle blood flow at the onset of exercise. Am J Physiol Heart Circ Physiol 277: H1872-H1877, 1999.
12. Burnstock G. Cholinergic and purinergic regulation of blood vessels. In: Handbook of Physiology. The Cardiovascular System. Vascular Smooth Muscle. Bethesda, MD: Am. Physiol. Soc, 1980, sect. 2, vol. II, chapt. 19, p. 567-612.
13. Corcondilas A, Koroxenidis GT, Shepherd JT. Effect of brief contraction of forearm muscles on forearm blood flow. J Appl Physiol 43: 801-806, 1964.
14. Diepstra G, Gonyea W, Mitchell JH. Cardiovascular response to static exercise during selective autonomic blockade in the conscious cat. Circ Res 47: 530-535, 1980.
15. Donald DE, Rowlands DJ, Ferguson DA. Similarity of blood flow in the normal and the sympathectomized dog hind limb during graded exercise. Circ Res 26: 185-199, 1970.
16. Dyke CK, Proctor DN, Dietz NM, Joyner MJ. Role of nitric oxide in exercise hyperaemia during prolonged rhythmic handgripping in humans. J Physiol 488: 259-265, 1995.
17. Eckberg DL, Mohanty SK, Raczkowska M. Trigeminal-baroreceptor reflex interactions modulate human cardiac vagal efferent activity. J Physiol 347: 75-83, 1984.
18. Eliasson S, Folkow B, Lindgren P, Uvnas B. Activation of sympathetic vasodilator nerves to the skeletal muscles in the cat by hypothalamic stimulation. Acta Physiol Scand 23: 333-351, 1951.
19. Ellison G, Zanchetti A. Diffuse and specific activation of sympathetic cholinergic fibers of the cat. Am J Physiol 225: 142-149, 1973.
20. Gilligan DM, Panza JA, Kilcoyne CM, Waclawiw MA, Casino PR, Quyyumi AA. Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation. Circulation 90: 2853-2858, 1994.
21. Gonyea WJ, Diepstra G, Muntz KH, Mitchell JH. Cardiovascular response to static exercise in the conscious cat. Circ Res 48: I63-I69, 1981.
22. Halliwill JR, Lawler LA, Eickhoff TJ, Dietz NM, Nauss LA, Joyner MJ. Forearm sympathetic withdrawal and vasodilatation during mental stress in humans. J Physiol 504: 211-220, 1997.
23. Huang A, Sun D, Smith CJ, Connetta JA, Shesely EG, Koller A, Kaley G. In eNOS knockout mice skeletal muscle arteriolar dilation to acetylcholine is mediated by EDHF. Am J Physiol Heart Circ Physiol 278: H762-H768, 2000.
24. Joyner MJ, Halliwill JR. Neurogenic vasodilation in human skeletal muscle: possible role in contraction-induced hyperaemia. Acta Physiol Scand 168: 481-488, 2000.
25. Kagaya A, Ogita F. Blood flow during muscle contraction and relaxation in rhythmic exercise at different intensities. Ann Physiol Anthropol 11: 251-256, 1992.
26. Komine H, Matsukawa K, Murata J, Tsuchimochi H, Shimizu K. Forelimb vasodilatation induced by hypothalamic stimulation is greatly mediated with nitric oxide in anesthetized cats. Jpn J Physiol 53: 97-103, 2003.
27. Komine H, Matsukawa K, Tsuchimochi H, Murata J. Central command blunts the baroreflex bradycardia to aortic nerve stimulation at the onset of voluntary static exercise in cats. Am J Physiol Heart Circ Physiol 285: H516-H526, 2003.
28. Laughin MH, Korthuis RJ, Duncker DJ, Bache RJ. Control of blood flow to cardiac and skeletal muscle during exercise. In: Handbook of Physiology. Exercise. Regulation and Integration of Multiple System. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, chapt. 16, p. 706-769.
29. Matsukawa K, Mitchell JH, Wall PT, Wilson LB. The effect of static exercise on renal sympathetic nerve activity in conscious cats. J Physiol 434: 453-467, 1991.
30. Matsukawa K, Ninomiya I. Anesthetic effects on tonic and reflex renal sympathetic nerve activity in awake cats. Am J Physiol Regul Integr Comp Physiol 256: R371-R378, 1989.
31. Matsukawa K, Shindo T, Shirai M, Ninomiya I. Nitric oxide mediates cat hindlimb cholinergic vasodilation induced by stimulation of posterior hypothalamus. Jpn J Physiol 43: 473-483, 1993.
32. Matsukawa K, Shindo T, Shirai M, Ninomiya I. Direct observations of sympathetic cholinergic vasodilatation of skeletal muscle small arteries in the cat. J Physiol 500: 213-225, 1997.
33. Matsukawa K, Shirai M, Murata J, Tsuchimochi H, Komine H, Ninomiya I, Shimizu K. Sympathetic cholinergic vasodilation of skeletal muscle small arteries. Jpn J Pharmacol 88: 14-18, 2002.
34. Murata J, Matsukawa K, Komine H, Tsuchimochi H, Nakamoto T. Central inhibition of the aortic baroreceptors-heart rate reflex at the onset of spontaneous muscle contraction. J Appl Physiol 97: 1371-1378, 2004.
35. Ninomiya I, Matsukawa K, Honda T, Nishiura N, Shirai M. Cardiac sympathetic nerve activity and heart rate during coronary occlusion in awake cats. Am J Physiol Heart Circ Physiol 251: H528-H537, 1986.
36. Radegran G, Saltin B. Nitric oxide in the regulation of vasomotor tone in human skeletal muscle. Am J Physiol Heart Circ Physiol 276: H1951-H1960, 1999.
37. Roddie IC. Human responses to emotional stress. Ir J Med Sci 146: 395-417, 1977.
38. Rowell LB. Human Circulation Regulation During Physical Stress. New York: Oxford University Press, 1986.
39. Ruble SB, Valic Z, Buckwalter JB, Clifford PS. Dynamic exercise attenuates sympathetic responsiveness of canine vascular smooth muscle. J Appl Physiol 89: 2294-2299, 2000.
40. Sanders JS, Mark AL, Ferguson DW. Evidence for cholinergically mediated vasodilation at the beginning of isometric exercise in humans. Circulation 79: 815-824, 1989.
41. Schrage WG, Joyner MJ, Dinenno FA. Local inhibition of nitric oxide and prostaglandins independently reduces forearm exercise hyperaemia in humans. J Physiol 557: 599-611, 2004.
42. Sheriff DD, Rowell LB, Scher AM. Is rapid rise in vascular conductance at onset of dynamic exercise due to muscle pump? Am J Physiol Heart Circ Physiol 265: H1227-H1234, 1993.
43. Shoemaker JK, Halliwill JR, Hughson RL, Joyner MJ. Contributions of acetylcholine and nitric oxide to forearm blood flow at exercise onset and recovery. Am J Physiol Heart Circ Physiol 273: H2388-H2395, 1997.
44. Shoemaker JK, Pozeg ZI, Hughson RL. Forearm blood flow by Doppler ultrasound during rest and exercise: tests of day-to-day repeatability. Med Sci Sports Exerc 28: 1144-1149, 1996.
45. Thomas GD, Segal SS. Neural control of muscle blood flow during exercise. J Appl Physiol 97: 731-738, 2004.
46. Tschakovsky ME, Sujirattanawimol K, Ruble SB, Valic Z, Joyner MJ. Is sympathetic neural vasoconstriction blunted in the vascular bed of exercising human muscle? J Physiol 541: 623-635, 2002.
47. Walther G, Nottin S, Dauzat M, Obert P. Femoral and axillary ultrasound blood flow during exercise: a methodological study. Med Sci Sports Exerc 38: 1353-1361, 2006.
48. Yamamoto Y, Nakamura Y, Sato H, Yamamoto M, Kato K, Hughson RL. On the fractal nature of heart rate variability in humans: effects of vagal blockade. Am J Physiol Regul Integr Comp Physiol 269: R830-R837, 1995.