메뉴 건너뛰기




Volumn 1247, Issue , 2009, Pages 38-49

Hypothalamospinal oxytocinergic antinociception is mediated by GABAergic and opiate neurons that reduce A-delta and C fiber primary afferent excitation of spinal cord cells

Author keywords

Analgesia; Opiate; Presynaptic inhibition; Rat Endogenous descending control

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; BETA FUNALTREXAMINE; BICUCULLINE; NALOXONE; OPIATE; OXYTOCIN; OXYTOCIN ANTAGONIST; OXYTOCIN RECEPTOR;

EID: 57349113072     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.10.030     Document Type: Article
Times cited : (60)

References (50)
  • 1
    • 0028799719 scopus 로고
    • The oxytocin antagonist 1-deamino-2-D-Tyr-(Oet)-4-Thr-8-Orn-oxytocin reverses the increase in the withdrawal response latency to thermal, but not mechanical nociceptive stimuli following oxytocin administration or massage-like stroking in rats
    • Agren G., Lundeberg T., Uvnas-Moberg K., and Sato A. The oxytocin antagonist 1-deamino-2-D-Tyr-(Oet)-4-Thr-8-Orn-oxytocin reverses the increase in the withdrawal response latency to thermal, but not mechanical nociceptive stimuli following oxytocin administration or massage-like stroking in rats. Neurosci. Lett. 187 (1995) 49-52
    • (1995) Neurosci. Lett. , vol.187 , pp. 49-52
    • Agren, G.1    Lundeberg, T.2    Uvnas-Moberg, K.3    Sato, A.4
  • 2
    • 0018133978 scopus 로고
    • Enkephalin-like material elevated in ventricular cerebrospinal fluid of pain patients after analgesic focal stimulation
    • Akil H., Richardson D.E., Hughes J., and Barchas J.D. Enkephalin-like material elevated in ventricular cerebrospinal fluid of pain patients after analgesic focal stimulation. Science 201 (1978) 463-465
    • (1978) Science , vol.201 , pp. 463-465
    • Akil, H.1    Richardson, D.E.2    Hughes, J.3    Barchas, J.D.4
  • 3
    • 0027418177 scopus 로고
    • Influence of oxytocin on nociception and morphine antinociception
    • Arletti R., Benelli A., and Bertolini A. Influence of oxytocin on nociception and morphine antinociception. Neuropeptides 24 (1993) 125-129
    • (1993) Neuropeptides , vol.24 , pp. 125-129
    • Arletti, R.1    Benelli, A.2    Bertolini, A.3
  • 4
    • 0031882905 scopus 로고    scopus 로고
    • Endogenous opioid peptides acting at μ-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons
    • Budai D., and Fields H.L. Endogenous opioid peptides acting at μ-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons. J. Neurophysiol. 79 (1998) 677-687
    • (1998) J. Neurophysiol. , vol.79 , pp. 677-687
    • Budai, D.1    Fields, H.L.2
  • 5
    • 0023805013 scopus 로고
    • Neurochemical organization of the hypothalamic projection to the spinal cord in the rat
    • Cechetto D.F., and Saper C.B. Neurochemical organization of the hypothalamic projection to the spinal cord in the rat. J. Comp. Neurol. 272 (1988) 579-604
    • (1988) J. Comp. Neurol. , vol.272 , pp. 579-604
    • Cechetto, D.F.1    Saper, C.B.2
  • 6
    • 0038404967 scopus 로고    scopus 로고
    • Actions of oxytocin and interactions with glutamate on spontaneous and evoked dorsal spinal cord neuronal activities
    • Condés-Lara M., Gonzalez N.M., Martinez-Lorenzana G., Delgado O.L., and Freund-Mercier M.J. Actions of oxytocin and interactions with glutamate on spontaneous and evoked dorsal spinal cord neuronal activities. Brain Res. 976 (2003) 75-81
    • (2003) Brain Res. , vol.976 , pp. 75-81
    • Condés-Lara, M.1    Gonzalez, N.M.2    Martinez-Lorenzana, G.3    Delgado, O.L.4    Freund-Mercier, M.J.5
  • 7
    • 19444376652 scopus 로고    scopus 로고
    • Oxytocin actions on afferent evoked spinal cord neuronal activities in neuropathic but not in normal rats
    • Condés-Lara M., Maie I.A., and Dickenson A.H. Oxytocin actions on afferent evoked spinal cord neuronal activities in neuropathic but not in normal rats. Brain Res. 1045 (2005) 124-133
    • (2005) Brain Res. , vol.1045 , pp. 124-133
    • Condés-Lara, M.1    Maie, I.A.2    Dickenson, A.H.3
  • 9
    • 0017909494 scopus 로고
    • Enkephalin and substance P containing neurons in the trigeminal and extrapyramidal system
    • Costa C., and Trabucchi (Eds), Raven Press
    • Cuello C. Enkephalin and substance P containing neurons in the trigeminal and extrapyramidal system. In: Costa C., and Trabucchi (Eds). Advances in Biochemical Psychopharmacology 18 (1978), Raven Press
    • (1978) Advances in Biochemical Psychopharmacology , vol.18
    • Cuello, C.1
  • 10
    • 0028169755 scopus 로고
    • Inhibitory actions of delta 1-, delta 2-, and mu-opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord
    • Glaum S.R., Miller R.J., and Hammond D.L. Inhibitory actions of delta 1-, delta 2-, and mu-opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord. J. Neurosci. 14 (1994) 4965-4971
    • (1994) J. Neurosci. , vol.14 , pp. 4965-4971
    • Glaum, S.R.1    Miller, R.J.2    Hammond, D.L.3
  • 11
    • 0030610223 scopus 로고    scopus 로고
    • GABAergic synapses on μ-opioid receptor-expressing neurons in the superficial dorsal horn: an electron microscope study in the cat spinal cord
    • Gong L.W., Ding Y.Q., and Wang D. GABAergic synapses on μ-opioid receptor-expressing neurons in the superficial dorsal horn: an electron microscope study in the cat spinal cord. Neurosci. Lett. 227 (1997) 33-36
    • (1997) Neurosci. Lett. , vol.227 , pp. 33-36
    • Gong, L.W.1    Ding, Y.Q.2    Wang, D.3
  • 12
    • 0016706732 scopus 로고
    • Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine
    • Hughes J. Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine. Brain Res. 88 (1975) 295-308
    • (1975) Brain Res. , vol.88 , pp. 295-308
    • Hughes, J.1
  • 14
    • 0032761747 scopus 로고    scopus 로고
    • Characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABA(A). receptor antagonist
    • Ishikawa T., Marsala M., Sakabe T., and Yaksh T.L. Characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABA(A). receptor antagonist. Neuroscience 95 (2000) 781-786
    • (2000) Neuroscience , vol.95 , pp. 781-786
    • Ishikawa, T.1    Marsala, M.2    Sakabe, T.3    Yaksh, T.L.4
  • 15
    • 0017622848 scopus 로고
    • Opiate analgesics inhibit substance P release from rat trigeminal nucleus
    • Jessell T.M., and Iversen L.L. Opiate analgesics inhibit substance P release from rat trigeminal nucleus. Nature 268 (1977) 549-551
    • (1977) Nature , vol.268 , pp. 549-551
    • Jessell, T.M.1    Iversen, L.L.2
  • 16
    • 0031942502 scopus 로고    scopus 로고
    • Electrophysiological properties of cultured neonatal rat dorsal horn neurons containing GABA and met-enkephalin-like immunoreactivity
    • Jo Y.H., Stoeckel E., and Schlichter R. Electrophysiological properties of cultured neonatal rat dorsal horn neurons containing GABA and met-enkephalin-like immunoreactivity. J. Neurophysiol. 79 (1998) 1583-1586
    • (1998) J. Neurophysiol. , vol.79 , pp. 1583-1586
    • Jo, Y.H.1    Stoeckel, E.2    Schlichter, R.3
  • 17
    • 0023188823 scopus 로고
    • Spinal pathways mediating tonic, coeruleospinal, and raphe-spinal descending inhibition in the rat
    • Jones S.L., and Gebhart G.F. Spinal pathways mediating tonic, coeruleospinal, and raphe-spinal descending inhibition in the rat. J. Neurophysiol. 58 (1987) 138-159
    • (1987) J. Neurophysiol. , vol.58 , pp. 138-159
    • Jones, S.L.1    Gebhart, G.F.2
  • 18
    • 0017074204 scopus 로고
    • Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section
    • Lamotte C., Pert C.B., and Snyder S.H. Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section. Brain Res. 112 (1976) 407-412
    • (1976) Brain Res. , vol.112 , pp. 407-412
    • Lamotte, C.1    Pert, C.B.2    Snyder, S.H.3
  • 19
    • 0035125663 scopus 로고    scopus 로고
    • Coadministration of intrathecal strychnine and bicuculline effects synergistic allodynia in the rat: an isobolographic analysis
    • Loomis C.W., Khandwala H., Osmond G., and Hefferan M.P. Coadministration of intrathecal strychnine and bicuculline effects synergistic allodynia in the rat: an isobolographic analysis. J. Pharmacol. Exp. Ther. 296 (2001) 756-761
    • (2001) J. Pharmacol. Exp. Ther. , vol.296 , pp. 756-761
    • Loomis, C.W.1    Khandwala, H.2    Osmond, G.3    Hefferan, M.P.4
  • 20
    • 0027402172 scopus 로고
    • Oxytocin modulates the effects of galanin in carrageenan-induced hyperalgesia in rats
    • Lundeberg T., Meister B., Bjorkstrand E., and Uvnas-Moberg K. Oxytocin modulates the effects of galanin in carrageenan-induced hyperalgesia in rats. Brain Res. 608 (1993) 181-185
    • (1993) Brain Res. , vol.608 , pp. 181-185
    • Lundeberg, T.1    Meister, B.2    Bjorkstrand, E.3    Uvnas-Moberg, K.4
  • 23
    • 0028181312 scopus 로고
    • μ-Opioid receptor-mediated reduction of neural calcium current occurs via Go-type GTP-binding protein
    • Moises H.C., Rusin K.I., and McDonald R.L. μ-Opioid receptor-mediated reduction of neural calcium current occurs via Go-type GTP-binding protein. J. Neurosci. 14 (1994) 3842-3851
    • (1994) J. Neurosci. , vol.14 , pp. 3842-3851
    • Moises, H.C.1    Rusin, K.I.2    McDonald, R.L.3
  • 24
    • 0025215981 scopus 로고
    • Long-term pain relief produced by intrathecal morphine infusion in 53 patients
    • Onofrio B.M., and Yaksh T.L. Long-term pain relief produced by intrathecal morphine infusion in 53 patients. J. Neurosurg. 72 (1990) 200-209
    • (1990) J. Neurosurg. , vol.72 , pp. 200-209
    • Onofrio, B.M.1    Yaksh, T.L.2
  • 26
    • 0034888815 scopus 로고    scopus 로고
    • Oxytocin decreases carrageenan induced inflammation in rats
    • Petersson M., Wiberg U., Lundeberg T., and Uvnas-Moberg K. Oxytocin decreases carrageenan induced inflammation in rats. Peptides 22 (2001) 1479-1484
    • (2001) Peptides , vol.22 , pp. 1479-1484
    • Petersson, M.1    Wiberg, U.2    Lundeberg, T.3    Uvnas-Moberg, K.4
  • 27
    • 0028158003 scopus 로고
    • Localization of oxytocin binding sites in the thoracic and upper lumbar spinal cord of the adult and postnatal rat: a histoautoradiographic study
    • Reiter M.K., Kremarik P., Freund-Mercier M.J., Stoeckel M.E., Desaulles E., and Feltz P. Localization of oxytocin binding sites in the thoracic and upper lumbar spinal cord of the adult and postnatal rat: a histoautoradiographic study. Eur. J. Neurosci. 6 (1994) 98-104
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 98-104
    • Reiter, M.K.1    Kremarik, P.2    Freund-Mercier, M.J.3    Stoeckel, M.E.4    Desaulles, E.5    Feltz, P.6
  • 30
    • 57349118791 scopus 로고    scopus 로고
    • Rojas-Piloni, G., Martinez-Lorenzana, G., DelaTorre, S., Condés-Lara, M., (in press). Nociceptive spinothalamic tract and post-synaptic dorsal column neurons are modulated by paraventricular hypothalamic activation. European J. Neurosci.
    • Rojas-Piloni, G., Martinez-Lorenzana, G., DelaTorre, S., Condés-Lara, M., (in press). Nociceptive spinothalamic tract and post-synaptic dorsal column neurons are modulated by paraventricular hypothalamic activation. European J. Neurosci.
  • 31
    • 0032743163 scopus 로고    scopus 로고
    • Presynaptic inhibition in the vertebrate spinal cord revisited
    • Rudomin P., and Schmidt R.F. Presynaptic inhibition in the vertebrate spinal cord revisited. Exp. Brain Res. 129 (1999) 1-37
    • (1999) Exp. Brain Res. , vol.129 , pp. 1-37
    • Rudomin, P.1    Schmidt, R.F.2
  • 33
    • 1342321739 scopus 로고    scopus 로고
    • Electrophysiological characterisations of rat lamina I dorsal horn neurones and the involvement of excitatory amino acid receptors
    • Seagrove L.C., Suzuki R., and Dickenson A.H. Electrophysiological characterisations of rat lamina I dorsal horn neurones and the involvement of excitatory amino acid receptors. Pain 108 (2004) 76-87
    • (2004) Pain , vol.108 , pp. 76-87
    • Seagrove, L.C.1    Suzuki, R.2    Dickenson, A.H.3
  • 34
    • 0029554657 scopus 로고
    • Effects of hypothalamic paraventricular nucleus: electrical stimulation produce marked analgesia in rats
    • Shiraishi T., Onoe M., Kojima T., Sameshima Y., and Kageyama T. Effects of hypothalamic paraventricular nucleus: electrical stimulation produce marked analgesia in rats. Neurobiology (Bp) 3 (1995) 393-403
    • (1995) Neurobiology (Bp) , vol.3 , pp. 393-403
    • Shiraishi, T.1    Onoe, M.2    Kojima, T.3    Sameshima, Y.4    Kageyama, T.5
  • 35
    • 0028168576 scopus 로고
    • The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord
    • Sivilotti L., and Woolf C.J. The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord. J. Neurophysiol. 72 (1994) 169-179
    • (1994) J. Neurophysiol. , vol.72 , pp. 169-179
    • Sivilotti, L.1    Woolf, C.J.2
  • 36
    • 0019517256 scopus 로고
    • Immunohistochemistry of vasopressin, oxytocin and neurophysin in the hypothalamus and extrahypothalamic regions of the human and primate brain
    • Sofroniew M.V., Weindl A., Schrell U., and Wetzstein R. Immunohistochemistry of vasopressin, oxytocin and neurophysin in the hypothalamus and extrahypothalamic regions of the human and primate brain. Acta Histochem. Suppl. 24 (1981) 79-95
    • (1981) Acta Histochem. Suppl. , vol.24 , pp. 79-95
    • Sofroniew, M.V.1    Weindl, A.2    Schrell, U.3    Wetzstein, R.4
  • 37
    • 0018668166 scopus 로고
    • The distribution of oxytocin- and neurophysin-stained fibers in the spinal cord of the rat and monkey
    • Swanson L.W., and McKellar S. The distribution of oxytocin- and neurophysin-stained fibers in the spinal cord of the rat and monkey. J. Comp. Neuro. 188 (1979) 87-106
    • (1979) J. Comp. Neuro. , vol.188 , pp. 87-106
    • Swanson, L.W.1    McKellar, S.2
  • 38
    • 0028792544 scopus 로고
    • Selective opioid inhibition of small nociceptive neurons
    • Taddese A., Nah S.Y., and McCleskey E.W. Selective opioid inhibition of small nociceptive neurons. Science 270 (1995) 1366-1369
    • (1995) Science , vol.270 , pp. 1366-1369
    • Taddese, A.1    Nah, S.Y.2    McCleskey, E.W.3
  • 39
    • 0026752966 scopus 로고
    • Immunohistochemical evidence that Met-enkephalin and GABA coexist in some neurones in rat dorsal horn
    • Todd A.J., Spike R.C., Russell G., and Johnston H.M. Immunohistochemical evidence that Met-enkephalin and GABA coexist in some neurones in rat dorsal horn. Brain Res. 584 (1992) 149-156
    • (1992) Brain Res. , vol.584 , pp. 149-156
    • Todd, A.J.1    Spike, R.C.2    Russell, G.3    Johnston, H.M.4
  • 43
    • 0027967989 scopus 로고
    • Activation of μ-opioid receptor modulates GABAA receptor-mediated currents in isolated spinal dorsal horn neurons
    • Wang R.A., and Randic M. Activation of μ-opioid receptor modulates GABAA receptor-mediated currents in isolated spinal dorsal horn neurons. Neurosci. Lett. 180 (1994) 109-113
    • (1994) Neurosci. Lett. , vol.180 , pp. 109-113
    • Wang, R.A.1    Randic, M.2
  • 44
    • 0021016561 scopus 로고
    • The properties of neurones recorded in the superficial dorsal horn of the rat spinal cord
    • Woolf C.J., and Fitzgerald M. The properties of neurones recorded in the superficial dorsal horn of the rat spinal cord. J. Comp. Neurol. 221 (1983) 313-328
    • (1983) J. Comp. Neurol. , vol.221 , pp. 313-328
    • Woolf, C.J.1    Fitzgerald, M.2
  • 45
    • 0028299604 scopus 로고
    • Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system
    • Yang J. Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system. Spine 19 (1994) 867-871
    • (1994) Spine , vol.19 , pp. 867-871
    • Yang, J.1
  • 46
    • 31344465495 scopus 로고    scopus 로고
    • Through the central V2, not V1 receptors influencing the endogenous opiate peptide system, arginine vasopressin, not oxytocin in the hypothalamic paraventricular nucleus involves in the antinociception in the rat
    • Yang J., Chen J.M., Song C.Y., Liu W.Y., Wang G., Wang C.H., and Lin B.C. Through the central V2, not V1 receptors influencing the endogenous opiate peptide system, arginine vasopressin, not oxytocin in the hypothalamic paraventricular nucleus involves in the antinociception in the rat. Brain Res. 1069 (2006) 127-138
    • (2006) Brain Res. , vol.1069 , pp. 127-138
    • Yang, J.1    Chen, J.M.2    Song, C.Y.3    Liu, W.Y.4    Wang, G.5    Wang, C.H.6    Lin, B.C.7
  • 47
    • 33846189851 scopus 로고    scopus 로고
    • Arginine vasopressin in periaqueductal gray, which relates to antinociception, comes from hypothalamic paraventricular nucleus in the rat
    • Yang J., Yang Y., Chen J.M., Xu H.T., Liu W.Y., and Lin B.C. Arginine vasopressin in periaqueductal gray, which relates to antinociception, comes from hypothalamic paraventricular nucleus in the rat. Neurosci. Lett. 412 (2007) 154-158
    • (2007) Neurosci. Lett. , vol.412 , pp. 154-158
    • Yang, J.1    Yang, Y.2    Chen, J.M.3    Xu, H.T.4    Liu, W.Y.5    Lin, B.C.6
  • 48
    • 0025598307 scopus 로고
    • Stimulation of the hypothalamic paraventricular nucleus produces analgesia not mediated by vasopressin or endogenous opioids
    • Yirmiya R., Ben-Eliyahu S., Shavit Y., Marek P., and Liebeskind J.C. Stimulation of the hypothalamic paraventricular nucleus produces analgesia not mediated by vasopressin or endogenous opioids. Brain Res. 537 (1990) 169-174
    • (1990) Brain Res. , vol.537 , pp. 169-174
    • Yirmiya, R.1    Ben-Eliyahu, S.2    Shavit, Y.3    Marek, P.4    Liebeskind, J.C.5
  • 49
    • 0041659298 scopus 로고    scopus 로고
    • Involvement of oxytocin in spinal antinociception in rats with inflammation
    • Yu S.Q., Lundeberg T., and Yu L.C. Involvement of oxytocin in spinal antinociception in rats with inflammation. Brain Res. 983 (2003) 13-22
    • (2003) Brain Res. , vol.983 , pp. 13-22
    • Yu, S.Q.1    Lundeberg, T.2    Yu, L.C.3
  • 50
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983) 109-110
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmermann, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.