Actions of oxytocin and interactions with glutamate on spontaneous and evoked dorsal spinal cord neuronal activities

Brain Research

Volumn 976, Issue 1, 2003, Pages 75-81

  Condés Lara, Miguel ^a,b   González, Nephtali Marina ^a   Martínez Lorenzana, Guadalupe ^a   Delgado, Oliva Luis ^b,c   Freund Mercier, Marie José ^c  

^a CENTRO DE FÍSICA APLICADA Y TECNOLOGÍA AVANZADA   (Mexico)

^b INSTITUTO NACIONAL DE PSIQUIATRÍA RAMÓN DE LA FUENTE MUÑIZ   (Mexico)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Oxytocin; Pain and analgesia; Sensorial modulation; Synaptic transmission and excitability

Indexed keywords

GLUTAMIC ACID; HALOTHANE; OXYTOCIN;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DORSAL ROOT; ELECTRODE; EVOKED SPINAL CORD RESPONSE; GRAY MATTER; HORMONE ACTION; INTERNEURON; LUMBAR SPINAL CORD; MALE; NERVE PROJECTION; NEUROMODULATION; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PIPETTE; PRIORITY JOURNAL; RAT; SOMATOSENSORY STIMULATION; SPINAL CORD NERVE CELL; TACTILE STIMULATION; THIGH; THORACIC SPINAL CORD;

EID: 0038404967     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(03)02690-8     Document Type: Article

References (41)

1. Alfven G., de la Torre B., Uvnas-Moberg K. Depressed concentrations of oxytocin and cortisol in children with recurrent abdominal pain of non-organic origin. Acta Pediatr. (Norway). 83:1994;1076-1080.
2. Arletti R., Benelli A., Bertolini A. Influence of oxytocin on nociception and morphine antinociception. Neuropeptides. 24:1993;125-129.
3. Buijs R.M. Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Pathways to the limbic system, medulla oblongata and spinal cord. Cell Tissue Res. 192:1978;423-435.
4. Burnstein R., Clieffer K.D., Giesler G.J. Direct somato-sensory projections from the spinal cord to the hypothalamus and telencephalon. J. Neurosci. 291:1987;329-344.
5. Carstens A.N.D., Mackinnon J.D., Winks M.J. Inhibition of spinal dorsal horn neuronal responses to noxious skin heating by medial preoptic and septal stimulation in the cat. J. Neurophysiol. 48:1982;981-991.
6. Cechetto D.F., Saper C.B. Neurochemical organization of the hypothalamic projection to the spinal cord in the rat. J. Comp. Neurol. 272:1988;579-604.
7. Charpak S., Armstrong W.E., Muhlethaler M., Dreifuss J.J. Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve. Brain Res. 300:1984;83-99.
8. Condés-Lara M., Veinante P., Rabai M., Freund-Mercier M.J. Correlation between oxytocin neuronal sensitivity and oxytocin-binding sites in the amygdala of the rat: electrophysiological and histoautoradiographic study. Brain Res. 637:1994;277-286.
9. Dado R.J., Katter J.T., Giesler G.J. Jr. Spinothalamic and spinohypothalamic tract neurons in the cervical enlargement of rats. I. Locations of antidromically identified axons in the thalamus and hypothalamus. J. Neurophysiol. 71:1994;959-980.
10. Dado R.J., Katter J.T., Giesler G.J. Jr. Spinothalamic and spinohypothalamic tract neurons in the cervical enlargement of rats. II. Responses to innocuous and noxious mechanical and thermal stimuli. J. Neurophysiol. 71:1994;981-1002.
11. Dado R.J., Katter J.T., Giesler G.J. Spinothalamic and spinohypothalamic tract neurons in the cervical enlargement of rats. III. Locations of antidromically identified axons in the cervical cord white matter. J. Neurophysiol. 71:1994;1003-1021.
12. Desaulles E., Reiter M.K., Feltz P. Electrophysiological evidence for oxytocin receptors on sympathetic preganglionic neurones - an in vitro study on the neonatal rat. Brain Res. 699:1995;139-142.
13. Ge Y., Lundeberg T., Yu L.C. Blockade effect of mu and kappa opioid antagonists on the anti-nociception induced by intra-periaqueductal grey injection of oxytocin in rats. Brain Res. 927:2002;204-207.
14. Gilbey M.P., Coote J.H., Fleetwood-Walker S., Peterson D.F. The influence of the paraventriculo-spinal pathway, and oxytocin and vasopressin on sympathetic preganglionic neurones. Brain Res. 251:1982;283-290.
15. Gimpl G., Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev. 81:2001;629-683.
16. Hallbeck M., Larhammar D., Blomqvist A. Neuropeptide expression in rat paraventricular hypothalamic neurons that project to the spinal cord. J. Comp. Neurol. 433:2001;222-238.
17. Jo Y.H., Stoeckel M.E., Freund-Mercier M.J., Schlichter R. Oxytocin modulates glutamatergic synaptic transmission between cultured neonatal spinal cord dorsal horn neurons. J. Neurosci. 18:1998;2377-2386.
18. Kabat H., Magoum H.W., Ranson S.W. Electrical stimulation of points in the forebrain and midbrain. The resultant alteration in blood pressure. Arch. Neurol. Psychiatr. (Chic.). 34:1935;931-940.
19. Kuipers H.G.J., Maisky V.A. Retrograde axonal transport of horseradish peroxidase from spinal cord to brain stem cell groups in the cat. Neurosci. Lett. 1:1975;9-14.
20. Lundeberg T., Uvnas-Moberg K., Agren G., Bruzelius G. Anti-nociceptive effects of oxytocin in rats and mice. Neurosci. Lett. 170:1994;153-157.
21. Madrazo I., Franco-Bourland R.E., Leon-Meza V.M., Mena I. Intraventricular somatostatin 14, arginine vasopressin and oxytocin: analgesic effect in a patient with intractable cancer pain. Appl. Neurophysiol. 50:1987;427-431.
22. Magoum H.W. Descending connections from the hypothalamus. Res. Publ. Assoc. Nerv. Ment. Dis. 20:1940;270-285.
23. Millan M.J., Schmauss C., Millan M.H., Herz A. Vasopressin and oxytocin in the rat spinal cord: analysis of their role in the control of nociception. Brain Res. 309:1984;384-388.
24. Muhlethaler M., Dreifuss J.J. Excitation of hippocampal neurones by posterior pituitary peptides: vasopressin and oxytocin compared. Prog. Brain Res. 60:1983;147-151.
25. Nilaver G., Zimmerman E.A., Wilkins J., Michaels J., Hoffman D., Silverman A.J. Magnocellular hypothalamic projections to the lower brain stem and spinal cord of the rat. Immunocytochemical evidence for predominance of the oxytocin-neurophysin system compared to the vasopressin-neurophysin system. Neuroendocrinology. 30:1980;150-158.
26. Raggenbass M., Dreifuss J.J. Mechanism of action of oxytocin in rat vagal neurones: induction of a sustained sodium-dependent current. J. Physiol. 457:1992;131-142.
27. Raggenbass M. Vasopressin- and oxytocin-induced activity in the central nervous system: electrophysiological studies using in-vitro systems. Prog. Neurobiol. 64:2001;307-326.
28. Reiter M.K., Kremarik P., Freund-Mercier M.J., Stoeckel M.E., Desaulles E., Feltz P. Localization of oxytocin binding sites in the thoracic and upper lumbar spinal cord of the adult and postnatal rat: a histoautoradiographic study. Eur. J. Neurosci. 6:1994;98-104.
29. Rousselot P., Papadopoulos G., Merighi A., Poulain D.A., Theodosis D.T. Oxytocinergic innervation of the rat spinal cord. An electron microscopic study. Brain Res. 529:1990;178-184.
30. Saper C.B., Loewy A.D., Swanson L.W., Cowan W.M. Direct hypothalamo-autonomic connections. Brain Res. 117:1976;305-312.
31. Sawchenko P.E., Swanson L.W. Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat. J. Comp. Neurol. 205:1982;260-272.
32. Sofroniew M.V., Weindl A., Schrell U., Wetzstein R. Immunohistochemistry of vasopressin, oxytocin and neurophysin in the hypothalamus and extrahypothalamic regions of the human and primate brain. Acta Histochem. Suppl. 24:1981;79-95.
33. Sofroniew M.V. Vasopressin- and neurophysin-immunoreactive neurons in the septal region, medial amygdala and locus coeruleus in colchicine-treated rats. Neuroscience. 2:1985;347-358.
34. Swanson L.W. Immunohistochemical evidence for a neurophysin-containing autonomic pathway arising in the paraventricular nucleus of the hypothalamus. Brain Res. 128:1977;346-353.
35. Swanson L.W., McKellar S. The distribution of oxytocin and neurophysin-stained fibers in the spinal cord of the rat and monkey. J. Comp. Neurol. 188:1979;87-106.
36. Toth Z.E., Gallatz K., Fodor M., Palkovits M. Decussations of the descending paraventricular pathways to the brainstem and spinal cord autonomic centers. J. Comp. Neurol. 414:1999;255-266.
37. Uvnas-Moberg K., Bruzelius G., Alster P., Bileviciute I., Lundeberg T. Oxytocin increases and a specific oxytocin antagonist decreases pain threshold in male rats. Acta Physiol. Scand. 144:1992;487-488.
38. Veronneau-Longueville F., Rampin O., Freund-Mercier M.J., Tang Y., Calas A., Marson L., et al. Oxytocinergic innervation of autonomic nuclei controlling penile erection in the rat. Neuroscience. 93:1999;1437-1447.
39. Workman B.J., Lumb BM B.M. Inhibitory effects evoked from the previous hypothalamus plows selective for the nociceptive responses of dorsal horn neurons with high and low threshold inputs. J. Neurophysiol. 77:1997;2831-2835.
40. Xu X.J., Wiesenfeld-Hallin Z. Is systemically administered oxytocin an analgesic in rats? Pain. 57:1994;193-196.
41. Yang J. Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system. Spine. 19:1994;867-871.