Effect of TA-270, a novel quinolinone derivative, on antigen-induced nasal blockage in a guinea pig model of allergic rhinitis

European Journal of Pharmacology

Volumn 602, Issue 1, 2009, Pages 138-142

  Mizutani, Nobuaki ^a   Aoki, Yasuo ^b   Nabe, Takeshi ^c   Ishiwara, Mitsuteru ^d   Yoshino, Shin ^a   Takagaki, Hidetsugu ^e   Kohno, Shigekatsu ^c  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^b Activus Pharma Co Ltd   (Japan)

^c KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^d DIC CORPORATION   (Japan)

^e TOHO UNIVERSITY   (Japan)

Author keywords

Allergic rhinitis; Cedar pollen; Leukotriene D4; Nasal blockage; Peroxynitrite; TA 270 4 hydroxy 1 methyl 3 octyloxy 7 sinapinoylamino 2(1H) quinolinone

Indexed keywords

4 HYDROXY 1 METHYL 3 OCTYLOXY 7 SINAPINOYLAMINO 2(1H) QUINOLINONE; NITRIC OXIDE; PEROXYNITRITE; QUINOLINE DERIVATIVE; SUPEROXIDE; TA 270; UNCLASSIFIED DRUG;

ALLERGIC RHINITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; GUINEA PIG; MALE; NONHUMAN; NOSE CONGESTION; PRIORITY JOURNAL; PROVOCATION TEST;

ALLERGENS; ANIMALS; ANTIGENS; CEDRUS; CINNAMATES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; LEUKOTRIENE D4; MALE; NASAL OBSTRUCTION; PEROXYNITROUS ACID; POLLEN; QUINOLONES; RHINITIS, ALLERGIC, SEASONAL; TIME FACTORS;

EID: 57349089100     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.11.006     Document Type: Article

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