REG I enhances chemo- and radiosensitivity in squamous cell esophageal cancer cells

Cancer Science

Volumn 99, Issue 12, 2008, Pages 2491-2495

  Hayashi, Kaori ^a   Motoyama, Satoru ^a   Koyota, Souichi ^a   Koizumi, Yukio ^a   Wang, Jingshu ^a   Takasawa, Shin ^b   Itaya Hironaka, Asako ^b   Sakuramoto Tsuchida, Sumiyo ^b   Maruyama, Kiyotomi ^a   Saito, Hajime ^a   Minamiya, Yoshihiro ^a   Ogawa, Jun Ichi ^a   Sugiyama, Toshihiro ^a  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CISPLATIN; FERROPORTIN 1; FLUOROURACIL; MESSENGER RNA;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CARCINOMA CELL; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CHEMOSENSITIVITY; CONTROLLED STUDY; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN ISOLATION; RADIOSENSITIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTIMETABOLITES, ANTINEOPLASTIC; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; ESOPHAGEAL NEOPLASMS; FLUOROURACIL; FORMAZANS; HUMANS; LITHOSTATHINE; PROTEINS; RADIATION TOLERANCE; RNA, MESSENGER; TETRAZOLIUM SALTS; TRANSFECTION;

EID: 57349088168     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2008.00980.x     Document Type: Article

References (41)

1. Enzinger PC, Mayer RJ. Esophageal cancer. N Eng J Med 2003; 349: 2241-51.
2. Ando N, Ozawa S, Kitagawa Y, Shinozawa Y, Kitajima M. Improvement in the results of surgical treatment of advanced squamous esophageal carcinoma during 15 consecutive years. Ann Surg 2000; 232: 225-32.
3. Tashiro T, Yamamori H, Takagi K et al. Changes in immune function following surgery for esophageal carcinoma. Nutrition 1999; 15: 760-6.
4. Fujita H, Kakegawa T, Yamana H et al. Mortality and morbidity rates, postoperative course, quality of life and prognosis after radical lymphadenectomy for esophageal cancer. Ann Surg 1995; 222: 654-62.
5. Hironaka S, Ohtsu A, Boku N et al. Nonrandomized comparison between definitive chemoradiotherapy and radical surgery in patients with T(2-3) N(any) M(0) squamous cell carcinoma of the esophagus. Int J Radiat Oncol 2003; 57: 425-33.
6. Ishikura S, Nihei K, Outhu A, Boku N et al. Long-term toxicity after definitive chemoradiotherapy for squamous cell carcinoma of the thoracic esophagus. J Clin Oncol 2003; 21: 2697-702.
7. Terazono K, Yamamoto H, Takasawa S et al. A novel gene activated in regenerating islets. J Biol Chem 1988; 263: 2111-14.
8. Sanchez D, Figarella C, Marchand-Pinatel S, Bruneau N, Guy-Crotte O. Preferential expression of Reg Iβ gene in human adult pancreas. Biochem Biophys Res Commun 2001; 284: 729-37.
9. Hervieu V, Christa L, Gouysse G et al. HIP/PAP, a number of the reg family, is expressed in glucagon-producing enteropancreatic endocrine cells and tumors. Hum Pathol 2006; 37: 1066-75.
10. Fukui H, Kinoshita Y, Maekawa T et al. Regenerating gene protein may mediate gastric mucosal proliferation induced by hypergastrinemia in rats. Gastroenterology 1998; 115: 1483-93.
11. Bishinupuri KS, Luo Q, Murmu N et al. Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas. Gastroenterology 2006; 130: 137-49.
12. Yonemura Y, Sakakura S, Yamamoto H et al. REG gene expression is associated with the infiltrating growth of gastric carcinoma. Cancer 2003; 98: 1394-400.
13. Shinozaki S, Nakamura T, Iimura M et al. Upregulation of Reg Iα and GW112 in the epithelium of inflamed colonic mucosa. Gut 2001; 48: 623-9.
14. Ose T, Kadowaki Y, Fukuhara H et al. Reg I-knockout mice reveal its role in regulation of cell growth that is required in generation and maintenance of the villous structure of small intestine. Oncogene 2007; 26: 349-59.
15. Harada K, Zen Y, Kanemori Y et al. Human REG I gene is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions. Hepatology 2001; 33: 1036-42.
16. Cavard C, Terris B, Grimber G et al. Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primary liver tumors with β-catenin mutations. Oncogene 2006; 25: 599-608.
17. Motoyama S, Sugiyama T, Ueno Y et al. REG I expression predicts long-term survival among locally advanced thoracic squamous cell esophageal cancer patient treated with neoadjuvant chemoradiotherapy followed by esophagectomy. Ann Surg Oncol 2006; 13: 1724-31.
18. Hayashi K, Motoyama S, Sugiyama T et al. REG Iα is a Reliable marker of chemoradiosensitivity in squamous cell esophageal cancer patients. Ann Surg Oncol 2008; 15: 1224-31.
19. Nishihira T, Hashimoto Y, Katayama M et al. Molecular and cellular features of esophageal cancer cells. J Cancer Res Clin Oncol 1993; 119: 441-9.
20. 2+ mobilization in normal and diabetic β-cells. J Biol Chem 1998; 273: 2497-500.
21. Kobayashi S, Akiyama T, Nata K et al. Identification of a receptor for Reg (regenerating gene) protein, a pancreatic β-cell regenerating factor. J Biol Chem 2000; 275: 10723-6.
22. Okamoto H, Takasawa S, Tohgo A et al. Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38: Inhibition of hydrolysis by ATP and physiological significance. Meth Enzymol 1997; 280: 306-18.
23. Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature 2004; 432: 316-23.
24. Sheridan MT, O'Dwyer T, Seymour CB, Mothersill CE. Potential indicators of radiosensitivity in squamous cell carcinoma of the head and neck. Radiat Oncol Invest 1997; 5: 180-6.
25. Xia F, Powell SN. The molecular basis of radiosensitivity and chemosensitivity in the treatment of breast cancer. Semin Radiat Oncol 2002; 12: 296-304.
26. Okumura H, Natsugoe S, Matsumoto M et al. The predictive value of p53, p53R2, and p21 for the effect of chemoradiation therapy on oesophageal squamous cell carcinoma. Br J Surg 2005; 92: 284-9.
27. Barnas C, Martel-Planche G, Furukawa Y et al. Inactivation of the p53 protein in cell lines derived from human esophageal cancers. Int J Cancer 1997; 71: 79-87.
28. Trent S, Yang C, Li C, Lynch M, Schmidt EV. Heat shock protein B8, a cyclin-dependent kinase-independent cyclin D1 target gene, contributes to its effects on radiation sensitivity. Cancer Res 2007; 67: 10774-81.
29. Hsaio M, Tse V, Carmel J et al. Functional expression of human p21 (WAFI/ CIPI) gene in rat glioma cells suppresses tumor growth in vivo and induces radiosensitivity. Biochem Biophys Res Commun 1997; 233: 329-35.
30. Matsumura Y, Yamagishi N, Miyakoshi J, Imamura S, Takebe H. Increase in radiation sensitivity of human malignant melanoma cells by expression of wild-type p16 gene. Cancer Lett 1997; 115: 91-6.
31. Sklar MD. The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation. Science 1988; 239: 645-7.
32. Kasid U, Pfeifer A, Weichselbaum RR, Dritschilo A, Mark GE. The raf oncogene is associated with a radiation-resistant human laryngeal cancer. Science 1987; 237: 1039-41.
33. Kumar P, Coltas IK, Kumar B, Chepeha DB, Bradford CR, Polverini PJ. Bcl-2 protects endothelial cells against gamma-radiation via a Raf-MEK-ERK-survivin signaling pathway that is independent of cytochrome c release. Cancer Res 2007; 67: 1193-202.
34. Takeuchi H, Ozawa S, Ando N et al. Cell-cycle regulators and the Ki-67 labeling index can predict the response to chemoradiotherapy and the survival of patients with locally advanced squamous cell carcinoma of the esophagus. Ann Surg Oncol 2003; 10: 792-800.
35. Wang KL, Wu TT, Choi IS et al. Expression of epidermal growth factor receptor in esophageal and esophagogastric junction adenocarcinomas. Cancer 2007; 109: 658-67.
36. Sakakura C, Miyagawa K, Fukuda KI et al. Frequent silencing of RUNX3 in esophageal cell carcinomas is associated with radioresistance and poor prognosis. Oncogene 2007; 26: 5927-38.
37. Verbrugge I, Vries ED, Tait SWG et al. Ionizing radiation modulates the TRAIL death-inducing signaling complex, allowing bypass of the mitochondrial apoptosis pathway. Oncogene 2008; 27: 574-84.
38. Albert JM, Cao C, Kim KW et al. Inhibition of poly (ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin Cancer Res 2007; 13: 3033-42.
39. Mitani Y, Matsumura S, Yoshida K et al. Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. Oncogene 2007; 26: 4383-93.
40. Takasawa S, Ikeda T, Akiyama T et al. Cyclin D1 activation through ATF-2 in Reg-induced pancreatic β-cell regeneration. FEBS Lett 2006; 580: 585-91.
41. Sekikawa A, Fukui H, Fujii S et al. REG Iα protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells. Carcinogenesis 2007; 29: 76-83.